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Chinese medicine granular containing notoginseng extract and preparation method thereof

A technology of traditional Chinese medicine granules and extracts, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc., and can solve the problems of low drug loading, poor taste, and lack of immediate release characteristics of granules

Active Publication Date: 2009-05-27
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Preparation of the active ingredient of the present invention:

[0076] Salvia miltiorrhiza extract: obtained according to the preparation method of Chinese patent application (application number 02117923.9). The specific extraction method is as follows: 5 kg of Salvia miltiorrhiza are crushed into coarse powder, and deionized water is added to heat and extract 3 times in a slightly boiling state at 100°C. The first time is 5.5 times the water, heating for 1 hour; the second and third times, each adding 3 times the amount of water to heat for 0.5 hours. After the extract was adjusted to pH 2 with 10% hydrochloric acid, it was filtered, and the filtrate was applied to a polyamide column (the amount of dry resin is 2 / 3 of the crude drug amount). Wash with 5 times the amount of deionized water, and continue to elute with 0.1% sodium bicarbonate aqueous solution, the amount is 5 times the column volume. Collect the eluent, adjust the pH to 2 with 10% hydrochloric acid, and then...

Embodiment 2

[0083] Preparation of the active ingredient of the present invention: take 1000 g of Salvia miltiorrhiza extract of Example 1, 2000 g of Panax notoginseng extract of Example 1, and 100 g of Dalbergia odorifera oil of Example 1 and mix them uniformly to prepare the active ingredient of the present invention;

[0084] Preparation of masterbatch: take a mixture of micronized silica gel and chitosan with a weight ratio of 1:1 and pass it through a 200-mesh sieve, of which 65% is used as the bottom material into the spray pot on the side of the fluidized bed, and PVP K30 is added with water, extract, and preparation Viscosity-forming agent-sprayed in as a slurry, and screened out small particles with a particle size of 120-180μ as the mother core, then put the mother core into the pot, continue to spray the starch slurry, and at the same time, the remaining 35% from the dusting gun The fine powder of silica gel and chitosan are sprinkled in to increase the particle size of the core, an...

Embodiment 3

[0087] Preparation of the active ingredient of the present invention: Take 3300 g of Salvia miltiorrhiza extract in Example 1, 267 g of Panax notoginseng extract in Example 1, and 300 g of Dalbergia odorifera oil in Example 1, and mix them uniformly to prepare the active ingredient of the present invention.

[0088] Preparation of masterbatch: Take a mixture of dextrin and starch with a weight ratio of 1:1 and pass it through a 200-mesh sieve, of which 65% is used as a base material and put into the spray pot on the side of the fluidized bed. 15% of the weight of the granules), add water to prepare a slurry and spray it in, and sift out small particles (with a particle size of 180-250μ) as the mother nucleus, and then put the mother nucleus into the pot, continue to spray the starch slurry, and at the same time from the powder gun Sprinkle the remaining 35% dextrin and starch fine powder to increase the particle size of the core, and select the masterbatch with a particle size of ...

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PUM

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Abstract

The invention provides a traditional Chinese medicine granular preparation with notoginseng extract and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using a traditional Chinese medicine extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g / ml to 1.3 g / ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing a panax notoginseng extract and a preparation method thereof. Background technique [0002] According to my country's epidemiological survey, the incidence and mortality of cardiovascular and cerebrovascular diseases have been on the rise in the past 50 years, whether in rural or urban areas. In the 1950s and 1960s, cardiovascular disease and cerebrovascular disease ranked fifth and sixth respectively among the causes of death in our country. After 1975, they rose to the second and third places. Cardiovascular and cerebrovascular disease deaths have accounted for the first cause of all deaths. The percentage of deaths due to cardiovascular and cerebrovascular diseases in my country has risen from 12.07% in 1957 to 42.6% in 2001. There are 2 million deaths from cardiovascular and cerebrovascu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K36/537A61K9/16A61P9/10A61K31/045
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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