Preparation method of compound bamboo leave flavone dripping pill

A technology of total flavonoids and bamboo leaves, which is applied in the direction of medical preparations containing active ingredients, pill delivery, pharmaceutical formulations, etc., can solve the problems of low dissolution rate and bioavailability, long dissolution time, etc., and achieve easy control of production conditions , fast dissolution time and high production efficiency

Inactive Publication Date: 2009-09-09
ZHEJIANG FORESTRY UNIVERSITY
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

However, most oral preparations of traditional Chinese medicines have disadvantages such as long dissolution time, low dissolution rate and low bioavailability after taking them.

Method used

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  • Preparation method of compound bamboo leave flavone dripping pill
  • Preparation method of compound bamboo leave flavone dripping pill
  • Preparation method of compound bamboo leave flavone dripping pill

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1) Take 7 parts of bamboo leaves and 3 parts of mimosa as raw materials of medicinal materials, mix them and crush them into coarse powder, pass through a 40-mesh sieve, and ultrasonically extract the coarse powder of medicinal materials with 8 times the amount of 60% aqueous ethanol at 50°C each time for 3 times, each time for 45 minutes, suction filtration, and combined filtrates;

[0033]2) Concentrate the filtrate to 1 / 4 of the original volume with a vacuum film at a water bath temperature of 50°C to obtain a concentrated solution, and use powdered activated carbon to sonicate the concentrated solution at 50°C for 25 minutes. The amount of powdered activated carbon is the dry weight of the medicinal material 1.5%, suction filtration, remove activated carbon, continue to concentrate the filtrate to 1 / 10 of the original volume with a vacuum film below 50°C, and obtain the concentrated solution again;

[0034] 3) Extract the concentrated solution obtained again in step...

Embodiment 2

[0039] Step 1) The weight ratio of the raw materials of Chinese medicinal materials is 6 parts of bamboo leaves and 4 parts of Mimosa, ultrasonically extracting with 6 times the amount of 70% aqueous ethanol for 40 min each time; in step 2), the ultrasonic time is 20 min, and the activated carbon is removed by suction filtration , to obtain the filtrate and continue to concentrate to 1 / 8 of the original volume. In step 4), the concentrated paste after n-butanol extraction is dissolved in a small amount of water, passes through the Diaion HP-20 macroporous adsorption resin column, and the diameter-to-height ratio of the chromatographic column is 1: 10. 2 O and 10% aqueous ethanol elution removes water-soluble impurities, then carries out gradient elution with 25% aqueous ethanol, 35% aqueous ethanol, 55% aqueous ethanol successively, and finally all removes all impurities with 70% aqueous ethanol elution, To regenerate the macroporous adsorption resin, the above elution flow ra...

Embodiment 3

[0041] Step 1) The weight ratio of the raw materials of Chinese medicinal materials is 8 parts of bamboo leaves and 2 parts of Mimosa, ultrasonically extracting with 9 times the amount of 65% aqueous ethanol for 50 min each time; in step 2), the ultrasonic time is 28 min, and the activated carbon is removed by suction filtration , to obtain the filtrate and continue to concentrate to 1 / 11 of the original volume. In step 4), the concentrated paste after n-butanol extraction is dissolved in a small amount of water, passes through the Diaion HP-20 macroporous adsorption resin column, and the diameter-to-height ratio of the chromatographic column is 1: 13. 2 O and 10% aqueous ethanol elution removes water-soluble impurities, then carries out gradient elution with 35% aqueous ethanol, 45% aqueous ethanol, 55% aqueous ethanol successively, and finally all removes all impurities with 70% aqueous ethanol elution, To regenerate the macroporous adsorption resin, the above elution flow r...

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Abstract

The invention discloses a preparation method of compound bamboo leave flavone dripping pill, belonging to the technical field of traditional Chinese medicine preparation. In the dripping pill preparation, Chinese herbal medicine bamboo leaves and mimosa are used as raw materials, a flavone extractive is obtained by extracting according to a certain method, and then the flavone extractive and pharmaceutical accessories used as matrix are processed by a certain method in proportion to prepare the final product. The dripping pill has the characteristics of high bioavailability, quick dissolution time, fast absorption by oral taking, high content of effective ingredients, accurate dosage, and convenient taking and carrying; the invention also has the functions of anti-lipid overoxidation, free radical removal, blood fat and cholesterolemia reduction, coronary blood flow increase, and myocardial ischemia melioration, and can be used for resisting oxidation, resisting aging, lowering blood fat, preventing and curing arteriosclerosis, cerebral ischemia, miocardial infarction and other diseases as well as the adjuvant therapy for cancer.

Description

technical field [0001] The invention belongs to the technical field of preparation methods of traditional Chinese medicines, in particular to a preparation method of compound total flavonoids from bamboo leaves dropping pills. Background technique [0002] Hyperlipidemia, high cholesterol, arteriosclerosis and other diseases are chronic diseases in modern society, which can lead to coronary heart disease, myocardial infarction, sudden cardiac death, high blood pressure, diabetes and other diseases. These diseases are the main causes of death among middle-aged and elderly people in recent years one. Therefore, it is of far-reaching significance to explore the treatment of traditional Chinese medicine for the above diseases and to develop new formulations of traditional Chinese medicine with significant clinical curative effect. However, most oral preparations of traditional Chinese medicines have disadvantages such as long dissolution time, low dissolution rate and low bioav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/20A61P3/06A61P9/10A61P39/06
Inventor 袁珂薛月芹喻卫武
Owner ZHEJIANG FORESTRY UNIVERSITY
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