Aniracetam drop pills

Aniracetam dripping pill and preparation technology, which is applied in the field of drug dripping pill preparation, can solve the problems of limiting the general use of senile dementia patients, inconvenience of individualization of the dose of senile dementia patients, and high production cost

Inactive Publication Date: 2005-07-06
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] In summary, as a symptomatic drug for the treatment of memory loss after Alzheimer's disease and cerebrovascular disease, Aniracetam has better curative effect than Piracetam, and has good safety; even though Aniracetam has many advantages, but The dosage forms currently used clinically are only ordinary tablets and granules, and their production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Aniracetam 5.0g

[0023] Polyethylene glycol-6000 14.5g

[0024] Polyethylene Glycol-1000 5.0g

[0025] Make 1000 capsules

[0026] Preparation process: Weigh the Aniracetam with the prescribed amount passed through a 100-mesh sieve, add it into the mixed solution containing the prescribed amount of polyethylene glycol 6000 and polyethylene glycol 1000 that has been heated and melted on a water bath, and stir fully to make it Mix well, put it into a drop bottle, and drip it under the condition of 95±2°C; drop it into a glass condensation column filled with methyl silicone oil at 4-6°C, take it out after molding, and use absorbent paper to absorb the adhered formazan Base silicone oil, that is.

Embodiment 2

[0028] Aniracetam 13.0g

[0029] Polyethylene glycol-6000 8.5g

[0030] Polyethylene Glycol-1000 3.0g

[0031] Make 1000 capsules

[0032] Preparation process: with embodiment 1.

Embodiment 3

[0034] Aniracetam 2.0g

[0035] Polyethylene glycol-6000 13.5g

[0036] Polyethylene glycol-1000 5.5g

[0037] Tween-60 2.5g

[0038] Make 1000 capsules

[0039]Preparation process: with embodiment 1.

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PUM

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Abstract

The invention provides an aniracetam drop pill wherein polyethylene glycol is selected from a plurality of drop pill base materials, a melting method is employed for preparing solid dispersions, based on this, the admission of the surface active agent and the integration boosting agent can facilitate the dissolving of drop pills. The invention has the advantages of convenient swallowing, rapid absorption, high biological availability, easy dosage dividing, thus is suitable for senile dementia patients.

Description

[0001] The technical field [0002] The invention belongs to medical technology, in particular to a medicine drop pill preparation technology. Background technique [0003] With the improvement of social living standards, the world's population is aging, and the average life expectancy of human beings is extended. It is reported that by 2000, the world's population will be close to 6 billion, and the elderly will be nearly 590 million. The elderly in my country will be about 100 million, and the proportion of the elderly will increase sharply. Cerebrovascular incidence increased significantly. Due to the rapid development of corresponding drug treatment, the mortality rate and disability rate of cerebrovascular diseases have been significantly reduced, while the number of patients with stroke sequelae and arteriosclerosis combined with mental and emotional disorders has increased sharply. There are about 10 million people in the world. According to data analysis, The disease i...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/40A61P25/28
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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