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Chinese medicine granular formulation containing Chinese angelica extract and preparation method thereof

A technology of angelica extract and traditional Chinese medicine granules, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulas, and medical preparations with non-active ingredients, etc., can solve the problems of unsightly appearance, poor taste, and low drug loading in granules.

Active Publication Date: 2009-05-27
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Extraction of extract: add 70% ethanol to angelica, chuanxiong, white peony root, and corydalis, heat and reflux for 2 hours, and store the reflux liquid in a separate container; the dregs and the rest of Rehmannia glutinosa, mother of pearl, Prunella vulgaris, cassia, chicken Add water to decoct the five flavors of blood rattan and other five flavors for three times, each time for 1 hour, add Uncaria uncaria in the third decoction, combine the decoction, concentrate under reduced pressure to a relative density of 1.09-1.13 (55°C), add ethanol to make the alcohol content reach 65 %, stand still for 24 hours, filter, the filtrate is combined with the above-mentioned reflux liquid, the ethanol is recovered under reduced pressure and concentrated to a relative density of 1.10-1.20 (55°C), and set aside.

[0056] Preparation of masterbatch: take the mixture of dextrin and starch (1:1) and pass it through a 200-mesh sieve, 65% of which will be used as the bottom material and ...

Embodiment 2

[0059]Preparation of extracts: add 60%-80% ethanol to Angelica, Chuanxiong, Radix Paeoniae Alba, Corydalis Corydalis, heat and reflux for 1-3 hours, store the reflux liquid in a separate container, mix medicinal residues with Rehmannia glutinosa, mother-of-pearl, Prunella vulgaris, cassia seeds, and Spatholobus Spatholobus Add water to decoct the five flavors for 3 times, each time for 1-2 hours, add Uncaria uncaria during the third decoction, combine the decoction, concentrate under reduced pressure to a relative density of 1.09-1.13, add ethanol to make the alcohol content reach 55-75% , stand still for 24 hours, the filtrate is combined with the above-mentioned reflux liquid, the ethanol is recovered under reduced pressure and concentrated to a relative density of 1.10-1.20 at 40-75 °C, and it is set aside;

[0060] Preparation of masterbatch: take a mixture of dextrin and polyethylene glycol at a ratio of 1:1 and pass through a 200-mesh sieve, 50% of which will be used as t...

Embodiment 3

[0063] Preparation of extracts: add 80% ethanol to Angelica, Chuanxiong, Baishao, and Corydalis, heat and reflux for 2 hours, store the reflux liquid in a separate container, decoct the medicinal residues with rehmannia glutinosa, mother-of-pearl, Prunella vulgaris, cassia seed, and Millet Spatholobus, etc. 3 times, 2 hours each time, add Uncaria uncariae during the third decoction, combine the decoction, concentrate under reduced pressure to a relative density of 1.09-1.13, add ethanol to make the alcohol content reach 55%, stand still for 24 hours, and the filtrate is refluxed with the above Liquids were combined, ethanol was recovered under reduced pressure and concentrated to a relative density of 1.10 to 1.20 at 40°C for later use;

[0064] Preparation of masterbatch: Take the mixture of dextrin and starch (1:1) and pass it through a 200-mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the base material, and take starch and extract (after bei...

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Abstract

The invention provides a traditional Chinese medicine granular preparation with angelica extract and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using a traditional Chinese medicine extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g / ml to 1.3 g / ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing angelica extract and a preparation method thereof. Background technique [0002] Headache is a common symptom in daily life, almost everyone will have a headache in their life. There are various causes of headaches. At present, there are many traditional Chinese medicine preparations for the treatment of headaches in China, but their slow onset is their main shortcoming, which affects the quality of life of patients. [0003] The traditional preparation method of traditional Chinese medicine granules is to make traditional Chinese medicine or its extracts into granular substances with a certain particle size by dry or wet methods, which are used by patients to drink or swallow with water. Several common granule preparation processes and their existing defects: 1. Traditional granule p...

Claims

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Application Information

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IPC IPC(8): A61K36/232A61K36/804A61K9/16A61K47/04A61K47/34A61K47/36A61K47/38A61K47/40A61P25/04A61K35/56A61K35/618A61K47/10
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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