New antibiotic composition
A technology of antibacterial drugs and compositions, applied in the field of medicine, can solve the problems of increasing β-lactamase strains, etc., and achieve the effect of enhancing antibacterial activity, enhancing clinical efficacy, and strong antibacterial activity
Inactive Publication Date: 2005-12-14
北京盛世伟唐科技有限公司
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AI Technical Summary
Problems solved by technology
However, it has been found clinically recently that many Gram-positive and negative bacteria are resistant to cefpiramide, and the number of β-lactamase-producing strains in many important pathogenic bacteria has increased significantly
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0009] The cefpiramide combination drug is prepared from 1 g of cefpiramide and 0.5 g of potassium clavulanate to make a combined preparation, which is operated according to the conventional powder injection production process.
Embodiment 2
[0011] Cefpiramide combination drug and 1 g of cefpiramide potassium clavulanate 0.5 g are prepared into a combined preparation, which is carried out according to the production process of conventional freeze-dried powder preparations.
Embodiment 3
[0013] The cefpiramide combination drug is made of 1 g of cefpiramide and 0.25 g of potassium clavulanate to make a combined preparation, which is operated according to the conventional powder injection production process.
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The antibiotic medicine composition is mixture of cefpiramide and beta-lactamase inhibitor in the weight ratio of 1 / 3 to 10. The cefpiramide may be replaced with alkali metal salt of cefpiramide or the mixture of cefpiramide, sodium carbonate and arginine. The beta-lactamase inhibitor may be clavulanic acid or its derivative, sulbactam or its derivative, or tazobactum or its derivative. The antibiotic medicine composition has high antibiotic effect, especially on sensitive bacteria and zymogenic bacteria, and wide antibiotic spectrum.
Description
technical field [0001] The invention belongs to the technical field of medicine and relates to a group of novel antibacterial drug compositions. Background technique [0002] Cefpiramide (Cefpiramide) is a semi-synthetic third-generation cephalosporin antibiotic. Its chemical structure is characterized by a methylthiotetrazolyl group at the 3-position side chain of the cephem core, and a hydroxyphenyl group and a hydroxyl group at the 9-position side chain. picoline. This product has the characteristics of broad antibacterial spectrum, strong antibacterial activity and stability to lactamase. It is effective against many Gram-positive cocci, including Staphylococcus and Enterococcus; it is also effective against Gram-negative bacilli and anaerobic bacteria, and has good antibacterial activity against Pseudomonas aeruginosa, similar to cefoperazone. This product is suitable for sensitive Gram-negative and positive bacteria such as Escherichia coli, Proteus, Klebsiella pneum...
Claims
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IPC IPC(8): A61K31/545
Inventor 刘军杨春玮孔庆文
Owner 北京盛世伟唐科技有限公司