New antibiotic composition

A technology of antibacterial drugs and compositions, applied in the field of medicine, can solve the problems of increasing β-lactamase strains, etc., and achieve the effect of enhancing antibacterial activity, enhancing clinical efficacy, and strong antibacterial activity

Inactive Publication Date: 2005-12-14
北京盛世伟唐科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has been found clinically recently that many Gram-positive and negative bacteria are resistant to cefpiramide, and the number of β-lactamase-producing strains in many important pathogenic bacteria has increased significantly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] The cefpiramide combination drug is prepared from 1 g of cefpiramide and 0.5 g of potassium clavulanate to make a combined preparation, which is operated according to the conventional powder injection production process.

Embodiment 2

[0011] Cefpiramide combination drug and 1 g of cefpiramide potassium clavulanate 0.5 g are prepared into a combined preparation, which is carried out according to the production process of conventional freeze-dried powder preparations.

Embodiment 3

[0013] The cefpiramide combination drug is made of 1 g of cefpiramide and 0.25 g of potassium clavulanate to make a combined preparation, which is operated according to the conventional powder injection production process.

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PUM

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Abstract

The antibiotic medicine composition is mixture of cefpiramide and beta-lactamase inhibitor in the weight ratio of 1/3 to 10. The cefpiramide may be replaced with alkali metal salt of cefpiramide or the mixture of cefpiramide, sodium carbonate and arginine. The beta-lactamase inhibitor may be clavulanic acid or its derivative, sulbactam or its derivative, or tazobactum or its derivative. The antibiotic medicine composition has high antibiotic effect, especially on sensitive bacteria and zymogenic bacteria, and wide antibiotic spectrum.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a group of novel antibacterial drug compositions. Background technique [0002] Cefpiramide (Cefpiramide) is a semi-synthetic third-generation cephalosporin antibiotic. Its chemical structure is characterized by a methylthiotetrazolyl group at the 3-position side chain of the cephem core, and a hydroxyphenyl group and a hydroxyl group at the 9-position side chain. picoline. This product has the characteristics of broad antibacterial spectrum, strong antibacterial activity and stability to lactamase. It is effective against many Gram-positive cocci, including Staphylococcus and Enterococcus; it is also effective against Gram-negative bacilli and anaerobic bacteria, and has good antibacterial activity against Pseudomonas aeruginosa, similar to cefoperazone. This product is suitable for sensitive Gram-negative and positive bacteria such as Escherichia coli, Proteus, Klebsiella pneum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/545
Inventor 刘军杨春玮孔庆文
Owner 北京盛世伟唐科技有限公司
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