Preparation of controlled release skeletal muscle relaxant dosage forms

a technology of skeletal muscle relaxant and oral dosage form, which is applied in the direction of biocide, muscular disorder, drug composition, etc., can solve the problem of patient compliance with oral administration of thrice daily
US20090148532A1Inactive Publication Date: 2009-06-11ADARE PHARM INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ADARE PHARM INC
Publication Date
2009-06-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is directed to a method of preparing an extended release pharmaceutical composition comprising cyclobenzaprine, comprising coating inert particles with a cyclobenzaprine-containing the drug layering composition and a seal coating composition to form IR beads, then coating the IR beads with an extended release coating to form ER beads.
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Description

[0001] This application claims priority to U.S. Provisional Application Ser. No. 61 / 074,464, filed Jun. 20, 2008, the disclosure of which is herein incorporated by reference in its entirety for all purposes.FIELD OF THE INVENTION

[0002] The present invention is directed to methods for preparing oral dosage forms of skeletal muscle relaxants, for example cyclobenzaprine. A major objective of developing and commercializing controlled release dosage forms for indications such as cardiovascular diseases, chronic pain, relief of muscle spasm and associated symptoms especially in the elderly is to deliver the drug so as to maintain the drug at therapeutically effective concentrations over an extended period of time, thereby enhancing patient compliance and therapeutic efficacy, thereby reducing both cost of treatment and side effects.BACKGROUND OF THE INVENTION

[0003] Many therapeutic agents are most effective when made available at a constant rate at or near the absorption site. The absorptio...

Claims

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