Cyclobenzaprine hydrochloride sustained-release capsule and preparation method thereof

Abstract

The invention relates to a cyclobenzaprine hydrochloride sustained-release capsule, the content of the cyclobenzaprine hydrochloride sustained-release capsule is a single cylinder formed by pressing mixed powder containing cyclobenzaprine hydrochloride, a sustained-release material and a lubricant, and the sustained-release material is selected from one or more of polyoxyethylene and hydroxypropyl methylcellulose. The cyclobenzaprine hydrochloride sustained-release capsule with an in-vitro dissolution behavior similar to that of a commercially available sustained-release pellet capsule is obtained by optimizing a sustained-release material of the capsule content. The preparation process of the preparation is simple, the quality is controllable, and the preparation is suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of medicines, in particular to a cyclobenzaprine hydrochloride sustained-release capsule. Background technique [0002] The chemical name of cyclobenzaprine hydrochloride is 5-(3-dimethylaminopropene) dibenzo[a,e] cycloheptatriene hydrochloride, which is a tricyclic muscle relaxant developed by Merck , which was approved for marketing in more than ten countries including the United States in the 1980s, is mainly used clinically to treat musculoskeletal discomfort or muscle spasms accompanied by pain symptoms. The drug can significantly relieve muscle spasms and relieve pain, tenderness, Associated symptoms such as exercise restriction and restriction of daily activities. The results of animal experiments show that cyclobenzaprine hydrochloride can not directly interfere with animal muscle nerve function or directly affect skeletal muscle function, and it mainly acts on the brain part of the central nervous system, ra...

AI Technical Summary

Problems solved by technology

The prescription of the above-mentioned sustained-release capsules is complicated, the process is cumbersome, the preparation process takes a long time, the parameters are controlled too much, and the process stability is greatly affected by the performance of the equipment.

In addition, the sustained-release capsules need to use a large amount

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