Cyclobenzaprine hydrochloride sustained-release tablet

Abstract

The invention provides a preparation method of a cyclobenzaprine hydrochloride sustained-release tablet, and belongs to the technical field of a medicine. The cyclobenzaprine hydrochloride sustained-release tablet disclosed by the invention consists of cyclobenzaprine hydrochloride, a sustained-release material, a pore-foaming agent, a filling agent, a lubricating agent and distilled water. The cyclobenzaprine hydrochloride, as a major ingredient, has effects of relieving muscle spasm as well as accompanied severe pain in skeletal muscle and the like; and the provided sustained-release preparation is safe and effective, stable in quality, low in cost and low in administration efficiency, and the sustained-release preparation is capable of enhancing patient compliance and is capable of stably stopping pain and relieving spasm.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation method of cyclobenzaprine hydrochloride sustained-release tablets. The invention provides a safe and effective drug with stable quality, low cost, less frequency of administration, enhanced patient compliance, and stable pain relief. Antispasmodic sustained-release formulation. Background technique [0002] Cyclobenzaprine hydrochloride, the chemical name is 5-(3-dimethylaminopropene) dibenzo[a,e] cycloheptatriene hydrochloride, the structural formula is: [0003] [0004] Molecular formula: C 20 h 21 N·HCl [0005] Molecular weight: 311.85 [0006] Musculoskeletal system diseases are more common in clinical practice, involving bones, intervertebral discs, nerves, muscles, joints, soft tissues and other diseases. There are also many causes of musculoskeletal pain, such as inflammation, mechanical injury, immune reasons, tumors, etc. Musculoskeletal pain occur...

AI Technical Summary

Problems solved by technology

[0010] In order to solve the shortcomings of the existing cyclobenzaprine hydrochloride preparations, which are inconvenient to take and have low bioavailability, the present invention invents cyclobenzaprine hydrochloride sustained-release tablets, which can reduce the number of times of taking the medicine, slow down the absorption rate, prolong the biological half-life, and increase the blood drug concentration. Control within the effective blood concentration range, thereby reducing side effects and improving patient compliance

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