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Cyclobenzaprine hydrochloride sustained release tablets and preparation method thereof

A technology of cyclobenzaprine hydrochloride and sustained-release tablets, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of being limited to rest and physical therapy, and achieve stable treatment Effect, convenient storage, simple and easy preparation method

Inactive Publication Date: 2015-02-18
HARBIN SHENGJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the medical market has not adapted to this new trend, and the treatment of back pain is still limited to the category of rest and physical therapy, and the development of central muscle relaxant drugs with exact curative effects has a good prospect

Method used

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  • Cyclobenzaprine hydrochloride sustained release tablets and preparation method thereof

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Embodiment 1

[0033] A cyclobenzaprine hydrochloride sustained-release tablet and a preparation method thereof, which are made of cyclobenzaprine hydrochloride, a sustained-release framework material, and a lubricant, wherein, in parts by weight, 15 parts of cyclobenzaprine hydrochloride, a sustained-release framework 75-80 parts of material, 5-10 parts of lubricant.

[0034] According to the optimal parts by weight, 15 parts of cyclobenzaprine hydrochloride, 80 parts of slow-release matrix material and 5 parts of lubricant.

[0035] The sustained-release matrix material is hypromellose.

[0036] The hypromellose is one or a mixture of 75hd100cr hypromellose, 75hd4000cr hypromellose, 75hd15000cr hypromellose, 100000cr hypromellose.

[0037] Described lubricant is magnesium stearate.

Embodiment 2

[0039] A cyclobenzaprine hydrochloride sustained-release tablet and a preparation method thereof, the specific steps of the preparation method are:

[0040] Step 1, material preparation: pulverize cyclobenzaprine hydrochloride with a pulverizer, pass through a 100-mesh sieve, and set aside;

[0041] Step 2: Total mixing: according to parts by weight, weigh cyclobenzaprine hydrochloride and hypromellose, put them into a three-dimensional mixer and mix for 30 minutes, take them out for later use;

[0042] Step 3: Granulation: Put the mixed fine powder of raw and auxiliary materials into the wet granulator, use pure water as the binder, put the binder into the liquid supply tank, turn on the machine, adjust the parameters, and start adding the moistening Wet agent, open the shear flying knife at the same time, 2-5 minutes, discharge, use a swing granulator, granulate with a 18-mesh nylon screen, use a fluidized bed dryer to dry, first dry with cool wind, wait After the s...

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Abstract

The invention provides cyclobenzaprine hydrochloride sustained release tablets. The cyclobenzaprine hydrochloride sustained release tablets are prepared from 15 parts of cyclobenzaprine hydrochloride, 75-80 parts of sustained release skeleton material and 5-10 parts of lubricating agent by weight. A preparation method of the cyclobenzaprine hydrochloride sustained release tablets comprises the steps of material preparing, blending, granulating, blending, tabletting and aluminium-plastic packaging. The cyclobenzaprine hydrochloride sustained release tablets are adjuvant medicines for treating painful local muscle spasm and have the beneficial effects that the novel sustained release preparations are adopted; sustained release refers to reducing the medicine release rates of medicines from the dosage forms and reducing the absorption rates of the medicines into bodies, thus achieving more stable treatment effects; compared with oral liquids, the cyclobenzaprine hydrochloride sustained release tablets have the advantages of good medicine stability, convenience in packaging, transportation and storage, and the like. The preparation method is simple and practicable and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of chemical medicine sustained-release preparations, in particular to a cyclobenzaprine hydrochloride sustained-release tablet and a preparation method thereof. Background technique [0002] In the era of the industrial revolution, back pain was considered to be a manifestation of fatigue. It was generally not called a "disease" and was usually treated with rest. However, rest could not solve the fundamental problem. You can't work at all, not only costing a lot of medical expenses, but also long-term and large-scale missed work will affect the gross social product. According to statistics, 50% to 80% of adults will experience back pain in their lifetime, and 12% to 15% of adults will suffer from it every year. [0003] Acute pain refers to back and lower back pain that lasts less than 3 months. The initial feeling is muscle spasm, muscle soreness, and limited local activities. The symptoms generally last for several...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/135A61K47/38A61P21/02A61J3/10
Inventor 马玉国
Owner HARBIN SHENGJI PHARMA
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