118 results about "Drug doses" patented technology

Systems and Methods are disclosed for detecting acute coronary syndrome (ACS) events, arrythmias, heart rate abnormalities, medication problems such as non-compliance or ineffective amount or type of medication, and demand / supply related cardiac ischemia. The system may have both implanted and external components that communicate with a Physicians's programmer, and smart-devices for monitoring and alerting to detected medically relevant events or states. At least one processor provides event detection using statistical threshold criteria calculated upon at least a portion of a patient's data / distributions and set for a patient or based upon what a doctor determines as abnormal for a patient. Cardiovascular condition is tracked using histogram, trend, and summary information related to heart rate and / or cardiac features such as S-T segment measures of heartbeats. Heartbeats with elevated rates, and below a “high” range, provide medically relevant detections including medication non-compliance. Novel methods of power management and patient monitoring are disclosed.

Systems, devices and methods are provided for determining a medication dose for a patient or user. The dose determination can account for recent and / or historical analyte levels of the patient or user. The dose determination can also take into account other information about the patient or user, such as physiological information, dietary information, activity, and / or behavior. Many different dose determination embodiments are set forth, pertaining to a wide array of different aspects of the system or environment in which the embodiments can be implemented.

The invention discloses an artificial intelligence-based whole doctor's advice reasonable medication auditing method and platform, and the method comprises the steps: integrating the structured data and unstructured text of a patient, carrying out the preprocessing according to a time sequence, determining a physiological safety range, and constructing a panoramic taboo doctor-seeing portrait; after deep information extraction and multi-source data fusion, a panoramic image of a patient is formed and is subjected to taboo comparison with medicine advised by a doctor, and a hard interception warning is triggered to avoid medicine conflict; further establishing a digital twinborn model, setting medical advices subjected to taboo comparison as a baseline scheme, simulating dynamic changes of physiological indexes within 72 hours, and assisting doctors to adjust drug doses in combination with clinical experience; finally, an individualized medication safety baseline is determined according to the simulation curve, and accurate simulation, dynamic early warning and scientific decision making are achieved. According to the scheme, the treatment safety and accuracy are remarkably improved, full-process intelligent medication auditing support is provided for complex patients, and the scheme has important clinical application value.

Dose guidance systems and methods for titrating medication doses are described. The dose guidance system may receive glucose data from a continuous glucose monitor and may receive medication data related to medication administered by the user. The dose guidance system may initialize dose guidance parameters, recommend medication doses, titrate medication doses, and provide alerts based on the glucose data and medication data.

The invention discloses an anti-radiation drug dose data acquisition self-adaptive dose control system. The system comprises a physiological parameter real-time acquisition module, a transfer environment data capture module, a multi-scale pharmacokinetic modeling module, a group Bayesian optimization calculation module, an anti-radiation drug dose adjustment module and a system parameter dynamic updating module. All the modules work cooperatively, the wounded physiological data and the transfer environment data are collected and input into the multi-scale pharmacokinetic modeling module to construct a cross-scale drug metabolism model, the group Bayesian optimization calculation module combines group data optimization calculation, and the anti-radiation drug dosage adjusting module adjusts the dosage according to the optimization calculation. And the system parameter dynamic updating module continuously corrects the parameters. According to the system, cross-scale analysis, group and individual data fusion and dynamic adaptation are achieved, it is ensured that the medicine dosage is accurate and appropriate in the transfer process, and a guarantee is provided for wounded treatment.

The present disclosure provides a caregiver system and method for interfacing with and controlling an oral medication dispensing device. The system registers the caregiver and provides the caregiver a list of patients under the caregiver's care, as well as associated medication dose schedules for each of the one or more patients. The caregiver is provided reminders regarding doses and allowed to modify the dose schedule to generate a modified dose schedule. The modified does schedule is pushed to a patient system associated with a medication dispensing device.

The invention belongs to the technical field of medical data processing, and discloses a multi-drug combined dose dynamic optimization method, equipment and a medium. The method comprises the following steps: constructing a multi-drug time-varying structure causal diagram; based on historical clinical observation data, performing causal effect learning on the structural causal diagram; in response to the current state input of a patient to be treated, carrying out anti-factual reasoning on the structure causality graph; an optimal dose combination is calculated that maximizes the desired efficacy and minimizes the uncertainty. According to the method, the structural causal diagram is constructed, the physiological state of the patient, multi-drug dose intervention, the pharmacokinetic process and the clinical outcome are uniformly modeled in the same causal framework, and the causal influence of the drug dose on the clinical outcome and the non-causal association relationship can be distinguished under the condition that historical clinical observation data are mixed and biased; and on this basis, anti-factual reasoning is performed on different dose combinations, so that potential clinical outcome distribution under assumed intervention conditions is obtained.

The invention relates to the technical field of atomizers, in particular to an intelligent atomization control system for medicine dosage homogenization, which comprises a temperature feedback control module, a laser granularity measurement module, an airflow fluctuation compensation module, a flow regulation module and a data analysis module. By intelligently controlling the flow, granularity, airflow and temperature of liquid medicine, accurate adjustment of the atomization process can be achieved, it is ensured that medicine is evenly and stably released in the whole treatment process, waste of the liquid medicine is remarkably reduced, the medicine utilization rate is increased, and by monitoring the temperature change in real time, the atomization effect is improved. The flow is adjusted to cope with the influence of temperature fluctuation on the liquid medicine flow characteristic and the atomization effect, medicine conveying stability in different environments is guaranteed, meanwhile, based on particle size control, airflow and flow can be adjusted in time to guarantee consistency of atomized particles, uneven medicine dosage caused by particle size fluctuation is avoided, and through airflow fluctuation compensation, the atomization effect is improved. It can be ensured that the influence on medicine flow is minimized when airflow is unstable, and dosage instability is avoided.

Medical devices and related systems and methods are provided. A method of controlling medication delivery based on sensor input involves obtaining a measurement parameter representing an electrical response of a first instance of a sensing element to a physiological condition of a person. The measurement parameter is converted into a calibrated measurement parameter using calibration data specific to the first instance of the sensing element. The method further involves determining a measurement value using the calibrated measurement parameter as input to a performance model. The performance model is derived from historical calibrated measurement parameters and corresponding reference values. The historical calibrated measurement parameters are from other instances of the sensing element. A command is then determined based on the measurement value and sent to a medical device. The command causes the medical device to deliver a dose of medication influencing the physiological condition of the person.

An autoinjector is configured to allow a user to suspend delivery of a medicament upon first activation of the autoinjector, and thereafter resume delivery of the medicament. The dose fractionated administration autoinjector may be operated to deliver a total desired dose of drug at multiple stages and / or at multiple injection sites.

The utility model provides a western medicine double -layer tablet production is with double hopper precision filling structure, belongs to production technical field, including first workstation, the surface of first workstation is installed with filling structure, and filling structure is used for filling to double -layer tablet, filling structure includes hopper, hopper fixedly arranged in the surface of first workstation, hopper sets up two, two hoppers are provided with the discharge gate, through the setting of filling structure, the transmission design of servo motor plus different number of teeth driven gear, through the transmission ratio of adjusting gear and pulley, can control the rotating speed of two hoppers inner impeller respectively, combine the accurate calculation of volume of impeller upper feed inlet, can realize independent, accurate quantitative feeding according to the filling amount demand (such as the upper layer and lower layer weight ratio of double -layer tablet) of two raw materials, makes two layers raw material weight deviation control in very small range, accords with the strict standard of tablet weight difference of pharmaceutical industry, ensures the medicine dose accurate.

The application provides a non-contact pain monitoring mattress and system based on multi-modal physiological signal fusion, the mattress body comprises, from bottom to top, a bottom support layer, a signal shielding layer, a sensing core layer and a breathable skin-friendly layer, the system comprises the non-contact pain monitoring mattress, a low-noise charge amplifier, a fiber demodulator, an edge computing gateway and a cloud analysis center, the data after signal conditioning is transmitted to the edge computing gateway and uploaded to the cloud analysis center, and the cloud analysis center performs quantitative scoring through a tumor-specific pain model.The application has the advantages that no electrode or wearable device needs to be pasted, the skin irritation and psychological burden of traditional monitoring are completely eliminated, the patient compliance is improved, the limitation of subjective evaluation is broken through, an objective pain evaluation method is provided for patients in the late stage / aphasia, multi-modal signal fusion monitoring is used to effectively distinguish pain from ordinary emotional fluctuations, the degree of pain is fed back in real time, the doctor is assisted in dynamically adjusting the dose of analgesic drugs, and the risk of drug overdose and deficiency is reduced.

The invention discloses a radiopharmaceutical dose automatic calibration method, which comprises the following steps of: performing charge state analysis on an iodine-131 radiopharmaceutical solution to determine the polarity and the intensity of an electrostatic charge required to be applied by a needle; before injection, static charges are applied to the needle head through the micro-current generating device, so that medicine can be effectively separated from the needle head after injection is completed, and residues are reduced; a high-precision micro-injection pump is combined with a pressure sensor to control the injection speed and dose output, and the fluid flowing state is monitored in real time to avoid abnormal conditions; after injection, a laser scattering detection module and an image recognition algorithm are used for capturing and evaluating the volume of residual liquid drops at the tail end of a needle head in real time, the dose needing to be additionally supplemented is calculated according to the volume, and it is ensured that a patient receives the accurate target dose; no needle residue is confirmed again after dose supplementation, so that the accuracy of the final administration dose is ensured; the whole system is flexible and high in adaptability, and can be adjusted according to the characteristics of different types of radiopharmaceuticals.

The present application relates to providing a doxorubicin-loaded anti-tumor hemostatic microsphere constructed by a simple, safe and low-cost method and its preparation and application, the doxorubicin-loaded anti-tumor hemostatic microsphere comprises alginate, hemostatic component A, doxorubicin or doxorubicin liposome, crosslinking agent, the hemostatic component A is selected from one or more of carboxymethyl chitosan, hyaluronic acid, collagen, silk fibroin, solve the practical pain point problems such as easy bleeding in tumor resection surgery, large toxicity of chemotherapeutic drugs, large drug dose, frequent drug administration, etc., realize rapid hemostasis in operation, postoperative precise targeted drug delivery, reduce toxic side effects, long-acting drug sustained release, at the same time, all components of the system are safe and reliable, and have good biocompatibility.

The present application relates to devices and methods for determining a drug administration regimen for a subject. Determining an administration regimen for a subject comprises calculating an amount of drug that needs to be administered to the subject per a base period, and determining and evaluating a combination of at least two dosage forms that can be used to administer the amount of drug against at least two different criteria. The methods of the present application can be used to select an administration regimen for a drug that is available in a plurality of dosage forms, especially a drug that is administered on a long-term daily basis, such as in the daily prophylaxis of hemophilia.

The invention discloses a drug curative effect prediction model for probiotic combined treatment of colon cancer, a construction method and a device, and belongs to the technical field of biological medicines. The invention provides a method for treating colon cancer through combination of probiotics, a mathematical model is constructed at the same time, the influence of an alpha value on the speed of a system tending to be balanced is analyzed, and it is obtained that initial conditions only influence the speed of the system tending to be balanced and do not influence the stability of the system. Meanwhile, the analysis of the influence of the drug dosage on the immune system finds that the tumor removal time can be obviously shortened by the full-dose triple therapy, the curative effect is obviously improved compared with that of a single drug or double drugs, and the action mechanism of a combined therapy scheme is disclosed: the invasion and transfer rate of CD4 + T cells can be obviously improved by increasing probiotics while the chemical immunotherapy dosage is fixed; the anti-tumor mechanism of the probiotics is to accurately adjust the immune system.

A system and method are provided for remotely supervised preparation, verification, and controlled dispensing of medication doses at geographically distributed remote dispensing units. A recipient and a supervisor are authenticated. A real-time audiovisual session is established between the recipient and at least the supervisor, and additional authenticated participants may join without authority to actuate dose release. The system receives an electronic medication order and corresponding label data originating from an external clinical information system and authorizes preparation of doses at the remote dispensing unit based on the order. Prior to any release, verification data is presented to the supervisor. A controlled mechanical transfer mechanism is actuated to release a prepared dose to the recipient only after verification and affirmative authorization by an authenticated supervisor. The disclosed systems and methods are applicable to controlled substances and other medications requiring supervised dispensing.

The present invention relates to a medicament delivery device comprising, a housing (10, 114) having a proximal and a distal end, a delivery member connected to the housing; a medicament container (84) operably arranged within the housing; a drive mechanism (102, 108) capable of acting on the medicament container (84) for priming and for expelling a dose of medicament. The invention is characterised in that the device further comprises—an activator mechanism configured to interact with the drive mechanism, such that a first interaction between the activator mechanism and the drive mechanism causes the container to move towards the delivery member wherein the container is primed and such that a subsequent second interaction between the activator mechanism and the drive mechanism causes a dose of medicament to be expelled through the delivery member.

The present invention relates to an injection amount measurement and management system for mounting on a pen-type injection device (1) having an injection button that does not rotate during injection, in order to measure the injection amount of a drug, and relates to an injection amount measurement and management system (100) for mounting on the dose-setting knob of a pen-type injection device, the system comprising: a main body (110) in which a main body IMU sensor (112) is installed; an injection button interlocking part (120) which is mounted so as to be interlocked with the rotational operation of an injection button (11) of the pen-type injection device (1) and has an injection button IMU sensor (121) installed therein; a main control unit (130); and an input / output interface (140), wherein the main control unit (130) calculates a relative angle change value (RA) between a measurement value of the main body IMU sensor (112) and a measurement value of the injection button IMU sensor (121), acquires a drug dose calculation value using the relative angle change value (RA) until injection is completed when the relative angle change value (RA) occurs in a return rotation direction, and then manages and displays the drug dose calculation value as injection history information.

A transfer device for transferring an array of doses of medicines, the transfer device comprising a body extending along a main axis between a top face located at an upper part of the body and a bottom face located at a lower part of the body, the top face including a group of entrance openings arranged in an entrance matrix in a plane transverse to the main axis at the level of the top face, the entrance openings each being arranged to receive a dose of medicines of the array, the body comprising a bundle of channels for passing doses of medicines therethrough, each channel extending along the body from a single entrance opening of the group of entrance openings to a single exit opening of a group of exit openings arranged in an exit matrix in a plane transverse to the main axis of the body at the level of the bottom face, at least one of the channels extending along the body with a component transverse to the main axis of the body so as to transpose the array of doses of medicines from a first spatial configuration corresponding to the entrance matrix to a second spatial configuration corresponding to the exit matrix.

The invention discloses a physiological index monitoring and drug delivery integrated system and an application thereof in wearable equipment, through integration of a microneedle array, a fluid chamber area, a piezoelectric sensing module, a drug controlled release module and a signal processing module, real-time monitoring of physiological indexes and automatic drug delivery are realized by using a double-chamber structure. The fluid chamber area is composed of a first fluid chamber and a second fluid chamber, the first fluid chamber and the second fluid chamber guide the flowing direction of a body fluid sample and medicine in a one-way mode through a microfluid channel and a one-way valve, and the first chamber is used for receiving and guiding the body fluid sample to the piezoelectric sensing module for physiological detection. The second chamber guides the medicine to the microneedle array for accurate delivery to realize real-time monitoring of physiological indexes and automatic medicine delivery, the piezoelectric sensing module guides a body fluid sample to the sensing unit and detects physiological parameters based on the acoustic surface wave effect, and the signal processing module controls the dosage of the medicine according to the detection result. And precise drug release is realized through the drug controlled release module.

Systems and methods are disclosed for predicting patient-specific CAR T drug product dose and optimizing CAR T drug product manufacturing. An example method includes: receiving quantitative data for a set of CAR T drug product dose parameters; generating an input feature vector comprising the quantitative data for the set of CAR T drug product dose parameters; and applying, into a trained machine learning model, the input feature vector to generate an output feature vector predicting a patient-specific CAR T drug product dose of a CAR T drug product for a target patient.

The invention belongs to the technical field of traditional Chinese medicine individuation, and provides a synergistic effect method of a traditional Chinese medicine dosage gradient scheme in insomnia treatment based on prescription dosage-efficiency science, which comprises the following steps: performing traditional Chinese medicine syndrome differentiation and typing on patients, and matching corresponding basic prescriptions according to syndromes; collecting individual characteristic parameters of a patient, and calculating an initial dose of traditional Chinese medicine according to the individual characteristic parameters; in the treatment cycle, the insomnia severity index and the Pittsburgh sleep quality index are adopted for curative effect evaluation, safety monitoring is conducted in combination with blood routine examination and liver and kidney function detection, and an evaluation result is obtained; according to an evaluation result, combining pharmacokinetic parameters, dynamically adjusting the dosage of the traditional Chinese medicine, and forming a dosage gradient scheme; synchronizing real-time lifestyle intervention and psychotherapy; through deep combination of the traditional Chinese medicine dialectical theory and modern pharmacokinetics, digital modeling and dynamic regulation and control are carried out on the dose-effect relationship of the traditional Chinese medicine, and the accuracy, safety and long-term curative effect of the traditional Chinese medicine for treating insomnia are ensured.

An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection.

Disclosed is a medicament dispenser for holding at least one elongate form medicament carrier. The elongate form medicament carrier has proximal and distal ends, and blister and lid elongate sheets enclosing multiple distinct medicament dose portions therebetween. The medicament dispenser has a dispensing mechanism which is adapted to operate, upon each actuation thereof, to dispense medicament active from the medicament dose portion. Moreover, the mechanism has at least one power spring mechanism for winding the lid elongate sheet, wherein the at least one power spring mechanism has at least one spring having an inner end about which the spring unwinds, and at least one shaft at which the inner end of at least one spring is secured. Furthermore, the power spring mechanism tensions and peels a segment of lid elongate sheet peeled from a corresponding segment of blister elongate sheet upon each actuation of the medicament dispenser. Disclosed also is a method of assembling the aforementioned medicament dispenser.

Use of a substituted purine compound or a pharmaceutically acceptable salt thereof for treating one or more of autism spectrum disorder (ASD), Rett syndrome (RTT), and Fragile X syndrome (FXS). A method for treating one or more of ASD, RTT, and FXS comprising administration of a substituted purine compound or a pharmaceutically acceptable salt thereof. Use of a substituted purine compound or a pharmaceutically acceptable salt thereof in the preparation of a pharmaceutical for the treatment of one or more of ASD, RTT, and FXS. A pharmaceutical dose of a substituted purine compound or a pharmaceutically acceptable salt thereof for use in the treatment of one or more of ASD, RTT, and FXS in a subject, wherein the dose comprises 5 to 1000 mg / kg, preferably 10 to 600 mg / kg, more preferably 25 to 100 mg / kg, most preferably about 40 mg / kg of the substituted purine compound or a pharmaceutically acceptable salt thereof.

Disclosed is an elongate form medicament carrier and a medicament dispenser. The medicament carrier has a first end, a second end, and a central portion, and carrying multiple distinct medicament dose portions, the medicament dose portions consisting of a first set and a second set of medicament dose portions, the first set of medicament dose portions distributed in a first portion of the elongate form medicament carrier between the first end and the central portion of the elongate form medicament carrier and containing a medicament active, or a mixture of medicament actives, and the second set of medicament dose portions distributed in a second portion of the elongate form medicament carrier between the second end and the central portion of the elongate form medicament carrier and containing a medicament active, or a mixture of medicament actives, wherein the dose portions in the second set of medicament dose portions are different from the dose portions in the first set of medicament dose portions.

The invention discloses a nutrition evaluation and personalized nutrition intervention system for children during hospitalization, and relates to the technical field of medical health information, and the system comprises a terminal which is used for collecting daily multi-omics data, medication data and nutrition intake data of children with metabolic diseases; the monitoring equipment is used for collecting daily growth and development data of the metabolic disease children; the processor is used for outputting daily metabolic capability data and nutrient utilization rate data through a neural network according to the multi-omics data; and according to the metabolic capability data and the medication data, performing linear calculation to obtain drug absorption data. According to the scheme, by constructing the knowledge base containing the quantitative parameters and combining interval matching, function calculation and a priority weighting mechanism, the actual influence degree on the nutrients in a multi-drug scene can be accurately calculated, the problem of nutrient influence evaluation deviation caused by neglecting drug dose difference and multi-drug interaction in the prior art is solved, and the evaluation accuracy is improved. The actual influence coefficient of the medicine on various nutrients can be accurately quantified.

An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection.

The utility model relates to the technical field of medicine production, and provides a filling machine for medicine production, which comprises a placing shell, a pressed plate is fixedly embedded on the inner surface of the placing shell, the top of the placing shell is fixedly connected with a top frame, the inner surface of the top frame is fixedly connected with a limiting rod, the outer surface of the limiting rod is movably sleeved with a limiting sleeve, and the limiting sleeve is fixedly connected with the top frame. And a movable plate is fixedly connected to one side of the limiting sleeve, a scraping plate is fixedly connected to the bottom of the movable plate, the bottom of the scraping plate is arranged on the top of the pressed plate, and an inner thread sleeve is fixedly connected to the end, away from the limiting sleeve, of the movable plate. The automatic slicking device is provided with an automatic slicking structure, so that powder or granular medicine filled in capsules can be leveled to a proper height, the medicine in each capsule is ensured to be on the same horizontal plane, the volume or weight of the medicine reaches a preset accurate dose, the large dose deviation of the medicine in each capsule is avoided, and the accuracy of the medicine in each capsule is improved. The quality and curative effect of the medicine are not influenced.