147 results about "Drug doses" patented technology

Systems and Methods are disclosed for detecting acute coronary syndrome (ACS) events, arrythmias, heart rate abnormalities, medication problems such as non-compliance or ineffective amount or type of medication, and demand / supply related cardiac ischemia. The system may have both implanted and external components that communicate with a Physicians's programmer, and smart-devices for monitoring and alerting to detected medically relevant events or states. At least one processor provides event detection using statistical threshold criteria calculated upon at least a portion of a patient's data / distributions and set for a patient or based upon what a doctor determines as abnormal for a patient. Cardiovascular condition is tracked using histogram, trend, and summary information related to heart rate and / or cardiac features such as S-T segment measures of heartbeats. Heartbeats with elevated rates, and below a “high” range, provide medically relevant detections including medication non-compliance. Novel methods of power management and patient monitoring are disclosed.

The art does not provide systematic and reproducible methods to personalize dosing of multiple immunosuppressive medications after transplantation. This invention provides a method to systematize multi-drug immuno suppression management in tissue and organ transplantation using an artificial intelligence-based complex systems approach. In embodiments of this invention, immunosuppression drug dose, blood drug concentrations, donor-derived fraction of cell free DNA (dd-cfDNA %), and aspartate aminotransferase are used to indicate allograft status or a proxy for allograft status, to generate a phenotypic response surface to produce individual treatment modalities and dosages using empirically determined unique coefficients. This surface is used to calculate appropriate immunosuppression drug doses associated with the desired outcome for that patient. Embodiments of this disclosure are directed to identifying optimized combinations of inputs for the complex system of the immunosuppressed transplant patient in order to avoid transplant rejection while avoiding unnecessary toxicity and maintaining a robust enough immune response to fight infection.

Systems, devices and methods are provided for determining a medication dose for a patient or user. The dose determination can account for recent and / or historical analyte levels of the patient or user. The dose determination can also take into account other information about the patient or user, such as physiological information, dietary information, activity, and / or behavior. Many different dose determination embodiments are set forth, pertaining to a wide array of different aspects of the system or environment in which the embodiments can be implemented.

The invention discloses a chronic disease dynamic monitoring and intervention system based on multi-modal data fusion and deep learning, and the system integrates a wearable sensing technology, a multi-modal data fusion algorithm, a deep learning model (DeepSeek) and a dynamic intervention strategy, and achieves the real-time monitoring, risk prediction and personalized management of chronic diseases. The system has the following functions: performing filing by inputting user information, performing reasoning processing by using a deep model after data acquisition, outputting short-term prediction and risk assessment results, and performing a dynamic personalized intervention scheme (including emergency event processing, drug dose optimization and behavior intervention strategies).

The invention discloses an artificial intelligence-based whole doctor's advice reasonable medication auditing method and platform, and the method comprises the steps: integrating the structured data and unstructured text of a patient, carrying out the preprocessing according to a time sequence, determining a physiological safety range, and constructing a panoramic taboo doctor-seeing portrait; after deep information extraction and multi-source data fusion, a panoramic image of a patient is formed and is subjected to taboo comparison with medicine advised by a doctor, and a hard interception warning is triggered to avoid medicine conflict; further establishing a digital twinborn model, setting medical advices subjected to taboo comparison as a baseline scheme, simulating dynamic changes of physiological indexes within 72 hours, and assisting doctors to adjust drug doses in combination with clinical experience; finally, an individualized medication safety baseline is determined according to the simulation curve, and accurate simulation, dynamic early warning and scientific decision making are achieved. According to the scheme, the treatment safety and accuracy are remarkably improved, full-process intelligent medication auditing support is provided for complex patients, and the scheme has important clinical application value.

The invention relates to the field of medical instruments, in particular to a respiratory capacity real-time monitoring method and system of a medical vaporizer. According to the method, the initial atomization airflow flow of the medical atomizer is obtained, the breathing signals of the user in the multiple breathing cycles are collected in the first preset time period, and the initial tidal volume information is obtained. Then, the respiratory signals are converted into a power spectrum density map through fast Fourier transform, inspiration waveforms are extracted to obtain tidal volume characteristic values, and deep analysis of the respiratory signals is achieved. Meanwhile, resistance values and temperature values of the heating wire in a plurality of respiratory cycles are collected, a temperature-resistance change coefficient is generated according to the data, and equipment performance changes are quantified. Based on this, the actual atomized airflow flow is calculated in combination with the initial atomized airflow flow and the coefficient. Finally, the actual atomization airflow flow, the tidal volume characteristic value and the coefficient are synthesized to obtain the actual tidal volume, the medicine dosage is matched according to the actual tidal volume, all the steps are linked with one another, and accurate treatment is achieved through multi-dimensional data integration.

The invention relates to the technical field of medical information, in particular to an endocrine patient long-term medication tracking management method and system, and the method comprises the following steps: extracting multiple pieces of key information in a prescription based on the electronic prescription information of a patient, recognizing the taking time and dosage information of multiple medicines, and sending medication reminding information to the patient, by monitoring the opening and closing state of the medicine box, the medicine taking time and quantity are recorded, and reminding and medicine taking monitoring information is generated. According to the method, the opening and closing state of the medicine box is monitored in real time, the taking time and quantity of medicine are recorded, the transparency of medicine treatment and the compliance of a patient are improved, physiological parameters of the patient are collected regularly, time sequence analysis and doctor feedback are matched, the change trend and periodic fluctuation of the illness state of the patient are accurately recognized, and the patient compliance is improved. By analyzing drug use logs of patients and doctors, effects of various drugs are identified, side effects are detected, drug doses and types are helped to be adjusted in time, the risk of adverse drug reactions is effectively reduced, and the treatment effect is improved.

Dose guidance systems and methods for titrating medication doses are described. The dose guidance system may receive glucose data from a continuous glucose monitor and may receive medication data related to medication administered by the user. The dose guidance system may initialize dose guidance parameters, recommend medication doses, titrate medication doses, and provide alerts based on the glucose data and medication data.

The invention discloses an anti-radiation drug dose data acquisition self-adaptive dose control system. The system comprises a physiological parameter real-time acquisition module, a transfer environment data capture module, a multi-scale pharmacokinetic modeling module, a group Bayesian optimization calculation module, an anti-radiation drug dose adjustment module and a system parameter dynamic updating module. All the modules work cooperatively, the wounded physiological data and the transfer environment data are collected and input into the multi-scale pharmacokinetic modeling module to construct a cross-scale drug metabolism model, the group Bayesian optimization calculation module combines group data optimization calculation, and the anti-radiation drug dosage adjusting module adjusts the dosage according to the optimization calculation. And the system parameter dynamic updating module continuously corrects the parameters. According to the system, cross-scale analysis, group and individual data fusion and dynamic adaptation are achieved, it is ensured that the medicine dosage is accurate and appropriate in the transfer process, and a guarantee is provided for wounded treatment.

The present disclosure provides a caregiver system and method for interfacing with and controlling an oral medication dispensing device. The system registers the caregiver and provides the caregiver a list of patients under the caregiver's care, as well as associated medication dose schedules for each of the one or more patients. The caregiver is provided reminders regarding doses and allowed to modify the dose schedule to generate a modified dose schedule. The modified does schedule is pushed to a patient system associated with a medication dispensing device.

The invention relates to the technical field of medical instruments, in particular to a multi-channel analgesia pump with remote monitoring and control functions, which comprises a disposable multi-channel analgesia pump and a non-disposable multi-channel analgesia pump, each of the disposable multi-channel analgesia pump and the non-disposable multi-channel analgesia pump comprises a multi-channel analgesia pump main body, a microfluidic liquid medicine delivery system, a multi-channel liquid medicine injection system, a wireless communication module and a remote control terminal. The disposable multi-channel analgesia pump or the non-disposable multi-channel analgesia pump can be selected according to the actual condition of a patient, and the flexibility and the practicability are high; by arranging the micro-fluidic liquid medicine delivery system, accurate release of liquid medicine doses in different channel liquid medicine injection units can be ensured, cross contamination of liquid medicine in the channel liquid medicine injection units is avoided, the analgesic effect is effectively improved, potential safety hazards caused by mixed use of the liquid medicine or inaccurate release of the liquid medicine are reduced, and the analgesic effect is improved. The safety and the effect of clinical treatment are improved.

The invention belongs to the technical field of medical data processing, and discloses a multi-drug combined dose dynamic optimization method, equipment and a medium. The method comprises the following steps: constructing a multi-drug time-varying structure causal diagram; based on historical clinical observation data, performing causal effect learning on the structural causal diagram; in response to the current state input of a patient to be treated, carrying out anti-factual reasoning on the structure causality graph; an optimal dose combination is calculated that maximizes the desired efficacy and minimizes the uncertainty. According to the method, the structural causal diagram is constructed, the physiological state of the patient, multi-drug dose intervention, the pharmacokinetic process and the clinical outcome are uniformly modeled in the same causal framework, and the causal influence of the drug dose on the clinical outcome and the non-causal association relationship can be distinguished under the condition that historical clinical observation data are mixed and biased; and on this basis, anti-factual reasoning is performed on different dose combinations, so that potential clinical outcome distribution under assumed intervention conditions is obtained.

The invention relates to the technical field of atomizers, in particular to an intelligent atomization control system for medicine dosage homogenization, which comprises a temperature feedback control module, a laser granularity measurement module, an airflow fluctuation compensation module, a flow regulation module and a data analysis module. By intelligently controlling the flow, granularity, airflow and temperature of liquid medicine, accurate adjustment of the atomization process can be achieved, it is ensured that medicine is evenly and stably released in the whole treatment process, waste of the liquid medicine is remarkably reduced, the medicine utilization rate is increased, and by monitoring the temperature change in real time, the atomization effect is improved. The flow is adjusted to cope with the influence of temperature fluctuation on the liquid medicine flow characteristic and the atomization effect, medicine conveying stability in different environments is guaranteed, meanwhile, based on particle size control, airflow and flow can be adjusted in time to guarantee consistency of atomized particles, uneven medicine dosage caused by particle size fluctuation is avoided, and through airflow fluctuation compensation, the atomization effect is improved. It can be ensured that the influence on medicine flow is minimized when airflow is unstable, and dosage instability is avoided.

Medical devices and related systems and methods are provided. A method of controlling medication delivery based on sensor input involves obtaining a measurement parameter representing an electrical response of a first instance of a sensing element to a physiological condition of a person. The measurement parameter is converted into a calibrated measurement parameter using calibration data specific to the first instance of the sensing element. The method further involves determining a measurement value using the calibrated measurement parameter as input to a performance model. The performance model is derived from historical calibrated measurement parameters and corresponding reference values. The historical calibrated measurement parameters are from other instances of the sensing element. A command is then determined based on the measurement value and sent to a medical device. The command causes the medical device to deliver a dose of medication influencing the physiological condition of the person.

An autoinjector is configured to allow a user to suspend delivery of a medicament upon first activation of the autoinjector, and thereafter resume delivery of the medicament. The dose fractionated administration autoinjector may be operated to deliver a total desired dose of drug at multiple stages and / or at multiple injection sites.

The utility model provides a western medicine double -layer tablet production is with double hopper precision filling structure, belongs to production technical field, including first workstation, the surface of first workstation is installed with filling structure, and filling structure is used for filling to double -layer tablet, filling structure includes hopper, hopper fixedly arranged in the surface of first workstation, hopper sets up two, two hoppers are provided with the discharge gate, through the setting of filling structure, the transmission design of servo motor plus different number of teeth driven gear, through the transmission ratio of adjusting gear and pulley, can control the rotating speed of two hoppers inner impeller respectively, combine the accurate calculation of volume of impeller upper feed inlet, can realize independent, accurate quantitative feeding according to the filling amount demand (such as the upper layer and lower layer weight ratio of double -layer tablet) of two raw materials, makes two layers raw material weight deviation control in very small range, accords with the strict standard of tablet weight difference of pharmaceutical industry, ensures the medicine dose accurate.

The application provides a non-contact pain monitoring mattress and system based on multi-modal physiological signal fusion, the mattress body comprises, from bottom to top, a bottom support layer, a signal shielding layer, a sensing core layer and a breathable skin-friendly layer, the system comprises the non-contact pain monitoring mattress, a low-noise charge amplifier, a fiber demodulator, an edge computing gateway and a cloud analysis center, the data after signal conditioning is transmitted to the edge computing gateway and uploaded to the cloud analysis center, and the cloud analysis center performs quantitative scoring through a tumor-specific pain model.The application has the advantages that no electrode or wearable device needs to be pasted, the skin irritation and psychological burden of traditional monitoring are completely eliminated, the patient compliance is improved, the limitation of subjective evaluation is broken through, an objective pain evaluation method is provided for patients in the late stage / aphasia, multi-modal signal fusion monitoring is used to effectively distinguish pain from ordinary emotional fluctuations, the degree of pain is fed back in real time, the doctor is assisted in dynamically adjusting the dose of analgesic drugs, and the risk of drug overdose and deficiency is reduced.

The invention discloses a radiopharmaceutical dose automatic calibration method, which comprises the following steps of: performing charge state analysis on an iodine-131 radiopharmaceutical solution to determine the polarity and the intensity of an electrostatic charge required to be applied by a needle; before injection, static charges are applied to the needle head through the micro-current generating device, so that medicine can be effectively separated from the needle head after injection is completed, and residues are reduced; a high-precision micro-injection pump is combined with a pressure sensor to control the injection speed and dose output, and the fluid flowing state is monitored in real time to avoid abnormal conditions; after injection, a laser scattering detection module and an image recognition algorithm are used for capturing and evaluating the volume of residual liquid drops at the tail end of a needle head in real time, the dose needing to be additionally supplemented is calculated according to the volume, and it is ensured that a patient receives the accurate target dose; no needle residue is confirmed again after dose supplementation, so that the accuracy of the final administration dose is ensured; the whole system is flexible and high in adaptability, and can be adjusted according to the characteristics of different types of radiopharmaceuticals.

The present application relates to providing a doxorubicin-loaded anti-tumor hemostatic microsphere constructed by a simple, safe and low-cost method and its preparation and application, the doxorubicin-loaded anti-tumor hemostatic microsphere comprises alginate, hemostatic component A, doxorubicin or doxorubicin liposome, crosslinking agent, the hemostatic component A is selected from one or more of carboxymethyl chitosan, hyaluronic acid, collagen, silk fibroin, solve the practical pain point problems such as easy bleeding in tumor resection surgery, large toxicity of chemotherapeutic drugs, large drug dose, frequent drug administration, etc., realize rapid hemostasis in operation, postoperative precise targeted drug delivery, reduce toxic side effects, long-acting drug sustained release, at the same time, all components of the system are safe and reliable, and have good biocompatibility.

A dose recording device for a drug delivery device, wherein the drug delivery device comprises a housing, a cartridge holder configured to receive a cartridge for holding a plurality of doses of a drug, and a dose setting member connected to the housing and configured to set the dose of the drug, is disclosed. The dose recording device comprises a device housing and a measurement system having an optical sensor connected to a portion of the device housing. The device housing is configured to be mounted to the dose setting member. The measurement system is configured to detect a relative movement of the device housing to the housing by means of the optical sensor and to store relative movement data so as to provide information on a delivery of the dose of the drug.

The present application relates to devices and methods for determining a drug administration regimen for a subject. Determining an administration regimen for a subject comprises calculating an amount of drug that needs to be administered to the subject per a base period, and determining and evaluating a combination of at least two dosage forms that can be used to administer the amount of drug against at least two different criteria. The methods of the present application can be used to select an administration regimen for a drug that is available in a plurality of dosage forms, especially a drug that is administered on a long-term daily basis, such as in the daily prophylaxis of hemophilia.

The invention discloses a drug curative effect prediction model for probiotic combined treatment of colon cancer, a construction method and a device, and belongs to the technical field of biological medicines. The invention provides a method for treating colon cancer through combination of probiotics, a mathematical model is constructed at the same time, the influence of an alpha value on the speed of a system tending to be balanced is analyzed, and it is obtained that initial conditions only influence the speed of the system tending to be balanced and do not influence the stability of the system. Meanwhile, the analysis of the influence of the drug dosage on the immune system finds that the tumor removal time can be obviously shortened by the full-dose triple therapy, the curative effect is obviously improved compared with that of a single drug or double drugs, and the action mechanism of a combined therapy scheme is disclosed: the invasion and transfer rate of CD4 + T cells can be obviously improved by increasing probiotics while the chemical immunotherapy dosage is fixed; the anti-tumor mechanism of the probiotics is to accurately adjust the immune system.

The invention belongs to the technical field of biological medicines, and particularly relates to a tetrahedral framework nucleic acid carrying a small molecule drug as well as a preparation method and application of the tetrahedral framework nucleic acid. According to the invention, good cell entry performance, editability, anti-inflammatory and anti-oxidation capability of tetrahedral framework nucleic acid and anti-inflammatory and osteogenesis promoting effects of a JAK inhibitor are combined, and the JAK inhibitor Upatinib (UPA) is successfully loaded onto the tetrahedral framework nucleic acid (tFNA) to obtain a tFNA / UPA compound (TUC); the TUC can significantly inhibit inflammatory reaction by inhibiting a JAK / STAT pathway on the premise of reducing the drug dosage, enhances a WNT signal pathway, promotes an osteogenesis function, more effectively treats rheumatoid arthritis, and has a wide application prospect.

A system and method are provided for remotely supervised preparation, verification, and controlled dispensing of medication doses at geographically distributed remote dispensing units. A recipient and a supervisor are authenticated. A real-time audiovisual session is established between the recipient and at least the supervisor, and additional authenticated participants may join without authority to actuate dose release. The system receives an electronic medication order and corresponding label data originating from an external clinical information system and authorizes preparation of doses at the remote dispensing unit based on the order. Prior to any release, verification data is presented to the supervisor. A controlled mechanical transfer mechanism is actuated to release a prepared dose to the recipient only after verification and affirmative authorization by an authenticated supervisor. The disclosed systems and methods are applicable to controlled substances and other medications requiring supervised dispensing.

An analyte monitoring system and method for an on-body sensor control device may have the ability to sense two or more analytes of a patient, the sensor control device comprising a processor and a memory, there are instructions for determining various machine states and outputs based on time-dependent sensor data for each analyte. The status and output may include: alarm conditions for one or more analytes; consulting a message; a correction of the analyte state estimate; indication of failure of the sensor control device, failure of the insulin delivery device, drug dose calculation; or analyzing the report. Examples of systems and methods for dual analytes including glucose and ketones are described. Data may be transmitted from the sensor control device to the reader device for output to a user.

The present invention relates to a medicament delivery device comprising, a housing (10, 114) having a proximal and a distal end, a delivery member connected to the housing; a medicament container (84) operably arranged within the housing; a drive mechanism (102, 108) capable of acting on the medicament container (84) for priming and for expelling a dose of medicament. The invention is characterised in that the device further comprises—an activator mechanism configured to interact with the drive mechanism, such that a first interaction between the activator mechanism and the drive mechanism causes the container to move towards the delivery member wherein the container is primed and such that a subsequent second interaction between the activator mechanism and the drive mechanism causes a dose of medicament to be expelled through the delivery member.

The present invention relates to an injection amount measurement and management system for mounting on a pen-type injection device (1) having an injection button that does not rotate during injection, in order to measure the injection amount of a drug, and relates to an injection amount measurement and management system (100) for mounting on the dose-setting knob of a pen-type injection device, the system comprising: a main body (110) in which a main body IMU sensor (112) is installed; an injection button interlocking part (120) which is mounted so as to be interlocked with the rotational operation of an injection button (11) of the pen-type injection device (1) and has an injection button IMU sensor (121) installed therein; a main control unit (130); and an input / output interface (140), wherein the main control unit (130) calculates a relative angle change value (RA) between a measurement value of the main body IMU sensor (112) and a measurement value of the injection button IMU sensor (121), acquires a drug dose calculation value using the relative angle change value (RA) until injection is completed when the relative angle change value (RA) occurs in a return rotation direction, and then manages and displays the drug dose calculation value as injection history information.

A transfer device for transferring an array of doses of medicines, the transfer device comprising a body extending along a main axis between a top face located at an upper part of the body and a bottom face located at a lower part of the body, the top face including a group of entrance openings arranged in an entrance matrix in a plane transverse to the main axis at the level of the top face, the entrance openings each being arranged to receive a dose of medicines of the array, the body comprising a bundle of channels for passing doses of medicines therethrough, each channel extending along the body from a single entrance opening of the group of entrance openings to a single exit opening of a group of exit openings arranged in an exit matrix in a plane transverse to the main axis of the body at the level of the bottom face, at least one of the channels extending along the body with a component transverse to the main axis of the body so as to transpose the array of doses of medicines from a first spatial configuration corresponding to the entrance matrix to a second spatial configuration corresponding to the exit matrix.

The invention discloses a physiological index monitoring and drug delivery integrated system and an application thereof in wearable equipment, through integration of a microneedle array, a fluid chamber area, a piezoelectric sensing module, a drug controlled release module and a signal processing module, real-time monitoring of physiological indexes and automatic drug delivery are realized by using a double-chamber structure. The fluid chamber area is composed of a first fluid chamber and a second fluid chamber, the first fluid chamber and the second fluid chamber guide the flowing direction of a body fluid sample and medicine in a one-way mode through a microfluid channel and a one-way valve, and the first chamber is used for receiving and guiding the body fluid sample to the piezoelectric sensing module for physiological detection. The second chamber guides the medicine to the microneedle array for accurate delivery to realize real-time monitoring of physiological indexes and automatic medicine delivery, the piezoelectric sensing module guides a body fluid sample to the sensing unit and detects physiological parameters based on the acoustic surface wave effect, and the signal processing module controls the dosage of the medicine according to the detection result. And precise drug release is realized through the drug controlled release module.

Systems and methods are disclosed for predicting patient-specific CAR T drug product dose and optimizing CAR T drug product manufacturing. An example method includes: receiving quantitative data for a set of CAR T drug product dose parameters; generating an input feature vector comprising the quantitative data for the set of CAR T drug product dose parameters; and applying, into a trained machine learning model, the input feature vector to generate an output feature vector predicting a patient-specific CAR T drug product dose of a CAR T drug product for a target patient.