72 results about "Drug doses" patented technology

Systems and Methods are disclosed for detecting acute coronary syndrome (ACS) events, arrythmias, heart rate abnormalities, medication problems such as non-compliance or ineffective amount or type of medication, and demand / supply related cardiac ischemia. The system may have both implanted and external components that communicate with a Physicians's programmer, and smart-devices for monitoring and alerting to detected medically relevant events or states. At least one processor provides event detection using statistical threshold criteria calculated upon at least a portion of a patient's data / distributions and set for a patient or based upon what a doctor determines as abnormal for a patient. Cardiovascular condition is tracked using histogram, trend, and summary information related to heart rate and / or cardiac features such as S-T segment measures of heartbeats. Heartbeats with elevated rates, and below a “high” range, provide medically relevant detections including medication non-compliance. Novel methods of power management and patient monitoring are disclosed.

Systems, devices and methods are provided for determining a medication dose for a patient or user. The dose determination can account for recent and / or historical analyte levels of the patient or user. The dose determination can also take into account other information about the patient or user, such as physiological information, dietary information, activity, and / or behavior. Many different dose determination embodiments are set forth, pertaining to a wide array of different aspects of the system or environment in which the embodiments can be implemented.

The invention belongs to the technical field of medical data processing, and discloses a multi-drug combined dose dynamic optimization method, equipment and a medium. The method comprises the following steps: constructing a multi-drug time-varying structure causal diagram; based on historical clinical observation data, performing causal effect learning on the structural causal diagram; in response to the current state input of a patient to be treated, carrying out anti-factual reasoning on the structure causality graph; an optimal dose combination is calculated that maximizes the desired efficacy and minimizes the uncertainty. According to the method, the structural causal diagram is constructed, the physiological state of the patient, multi-drug dose intervention, the pharmacokinetic process and the clinical outcome are uniformly modeled in the same causal framework, and the causal influence of the drug dose on the clinical outcome and the non-causal association relationship can be distinguished under the condition that historical clinical observation data are mixed and biased; and on this basis, anti-factual reasoning is performed on different dose combinations, so that potential clinical outcome distribution under assumed intervention conditions is obtained.

The invention relates to the technical field of atomizers, in particular to an intelligent atomization control system for medicine dosage homogenization, which comprises a temperature feedback control module, a laser granularity measurement module, an airflow fluctuation compensation module, a flow regulation module and a data analysis module. By intelligently controlling the flow, granularity, airflow and temperature of liquid medicine, accurate adjustment of the atomization process can be achieved, it is ensured that medicine is evenly and stably released in the whole treatment process, waste of the liquid medicine is remarkably reduced, the medicine utilization rate is increased, and by monitoring the temperature change in real time, the atomization effect is improved. The flow is adjusted to cope with the influence of temperature fluctuation on the liquid medicine flow characteristic and the atomization effect, medicine conveying stability in different environments is guaranteed, meanwhile, based on particle size control, airflow and flow can be adjusted in time to guarantee consistency of atomized particles, uneven medicine dosage caused by particle size fluctuation is avoided, and through airflow fluctuation compensation, the atomization effect is improved. It can be ensured that the influence on medicine flow is minimized when airflow is unstable, and dosage instability is avoided.

Medical devices and related systems and methods are provided. A method of controlling medication delivery based on sensor input involves obtaining a measurement parameter representing an electrical response of a first instance of a sensing element to a physiological condition of a person. The measurement parameter is converted into a calibrated measurement parameter using calibration data specific to the first instance of the sensing element. The method further involves determining a measurement value using the calibrated measurement parameter as input to a performance model. The performance model is derived from historical calibrated measurement parameters and corresponding reference values. The historical calibrated measurement parameters are from other instances of the sensing element. A command is then determined based on the measurement value and sent to a medical device. The command causes the medical device to deliver a dose of medication influencing the physiological condition of the person.

The application provides a non-contact pain monitoring mattress and system based on multi-modal physiological signal fusion, the mattress body comprises, from bottom to top, a bottom support layer, a signal shielding layer, a sensing core layer and a breathable skin-friendly layer, the system comprises the non-contact pain monitoring mattress, a low-noise charge amplifier, a fiber demodulator, an edge computing gateway and a cloud analysis center, the data after signal conditioning is transmitted to the edge computing gateway and uploaded to the cloud analysis center, and the cloud analysis center performs quantitative scoring through a tumor-specific pain model.The application has the advantages that no electrode or wearable device needs to be pasted, the skin irritation and psychological burden of traditional monitoring are completely eliminated, the patient compliance is improved, the limitation of subjective evaluation is broken through, an objective pain evaluation method is provided for patients in the late stage / aphasia, multi-modal signal fusion monitoring is used to effectively distinguish pain from ordinary emotional fluctuations, the degree of pain is fed back in real time, the doctor is assisted in dynamically adjusting the dose of analgesic drugs, and the risk of drug overdose and deficiency is reduced.

The present application relates to providing a doxorubicin-loaded anti-tumor hemostatic microsphere constructed by a simple, safe and low-cost method and its preparation and application, the doxorubicin-loaded anti-tumor hemostatic microsphere comprises alginate, hemostatic component A, doxorubicin or doxorubicin liposome, crosslinking agent, the hemostatic component A is selected from one or more of carboxymethyl chitosan, hyaluronic acid, collagen, silk fibroin, solve the practical pain point problems such as easy bleeding in tumor resection surgery, large toxicity of chemotherapeutic drugs, large drug dose, frequent drug administration, etc., realize rapid hemostasis in operation, postoperative precise targeted drug delivery, reduce toxic side effects, long-acting drug sustained release, at the same time, all components of the system are safe and reliable, and have good biocompatibility.

The present application relates to devices and methods for determining a drug administration regimen for a subject. Determining an administration regimen for a subject comprises calculating an amount of drug that needs to be administered to the subject per a base period, and determining and evaluating a combination of at least two dosage forms that can be used to administer the amount of drug against at least two different criteria. The methods of the present application can be used to select an administration regimen for a drug that is available in a plurality of dosage forms, especially a drug that is administered on a long-term daily basis, such as in the daily prophylaxis of hemophilia.

The invention discloses a drug curative effect prediction model for probiotic combined treatment of colon cancer, a construction method and a device, and belongs to the technical field of biological medicines. The invention provides a method for treating colon cancer through combination of probiotics, a mathematical model is constructed at the same time, the influence of an alpha value on the speed of a system tending to be balanced is analyzed, and it is obtained that initial conditions only influence the speed of the system tending to be balanced and do not influence the stability of the system. Meanwhile, the analysis of the influence of the drug dosage on the immune system finds that the tumor removal time can be obviously shortened by the full-dose triple therapy, the curative effect is obviously improved compared with that of a single drug or double drugs, and the action mechanism of a combined therapy scheme is disclosed: the invasion and transfer rate of CD4 + T cells can be obviously improved by increasing probiotics while the chemical immunotherapy dosage is fixed; the anti-tumor mechanism of the probiotics is to accurately adjust the immune system.

A system and method are provided for remotely supervised preparation, verification, and controlled dispensing of medication doses at geographically distributed remote dispensing units. A recipient and a supervisor are authenticated. A real-time audiovisual session is established between the recipient and at least the supervisor, and additional authenticated participants may join without authority to actuate dose release. The system receives an electronic medication order and corresponding label data originating from an external clinical information system and authorizes preparation of doses at the remote dispensing unit based on the order. Prior to any release, verification data is presented to the supervisor. A controlled mechanical transfer mechanism is actuated to release a prepared dose to the recipient only after verification and affirmative authorization by an authenticated supervisor. The disclosed systems and methods are applicable to controlled substances and other medications requiring supervised dispensing.

The present invention relates to a medicament delivery device comprising, a housing (10, 114) having a proximal and a distal end, a delivery member connected to the housing; a medicament container (84) operably arranged within the housing; a drive mechanism (102, 108) capable of acting on the medicament container (84) for priming and for expelling a dose of medicament. The invention is characterised in that the device further comprises—an activator mechanism configured to interact with the drive mechanism, such that a first interaction between the activator mechanism and the drive mechanism causes the container to move towards the delivery member wherein the container is primed and such that a subsequent second interaction between the activator mechanism and the drive mechanism causes a dose of medicament to be expelled through the delivery member.

The present invention relates to an injection amount measurement and management system for mounting on a pen-type injection device (1) having an injection button that does not rotate during injection, in order to measure the injection amount of a drug, and relates to an injection amount measurement and management system (100) for mounting on the dose-setting knob of a pen-type injection device, the system comprising: a main body (110) in which a main body IMU sensor (112) is installed; an injection button interlocking part (120) which is mounted so as to be interlocked with the rotational operation of an injection button (11) of the pen-type injection device (1) and has an injection button IMU sensor (121) installed therein; a main control unit (130); and an input / output interface (140), wherein the main control unit (130) calculates a relative angle change value (RA) between a measurement value of the main body IMU sensor (112) and a measurement value of the injection button IMU sensor (121), acquires a drug dose calculation value using the relative angle change value (RA) until injection is completed when the relative angle change value (RA) occurs in a return rotation direction, and then manages and displays the drug dose calculation value as injection history information.

A transfer device for transferring an array of doses of medicines, the transfer device comprising a body extending along a main axis between a top face located at an upper part of the body and a bottom face located at a lower part of the body, the top face including a group of entrance openings arranged in an entrance matrix in a plane transverse to the main axis at the level of the top face, the entrance openings each being arranged to receive a dose of medicines of the array, the body comprising a bundle of channels for passing doses of medicines therethrough, each channel extending along the body from a single entrance opening of the group of entrance openings to a single exit opening of a group of exit openings arranged in an exit matrix in a plane transverse to the main axis of the body at the level of the bottom face, at least one of the channels extending along the body with a component transverse to the main axis of the body so as to transpose the array of doses of medicines from a first spatial configuration corresponding to the entrance matrix to a second spatial configuration corresponding to the exit matrix.

Systems and methods are disclosed for predicting patient-specific CAR T drug product dose and optimizing CAR T drug product manufacturing. An example method includes: receiving quantitative data for a set of CAR T drug product dose parameters; generating an input feature vector comprising the quantitative data for the set of CAR T drug product dose parameters; and applying, into a trained machine learning model, the input feature vector to generate an output feature vector predicting a patient-specific CAR T drug product dose of a CAR T drug product for a target patient.

Disclosed is a medicament dispenser for holding at least one elongate form medicament carrier. The elongate form medicament carrier has proximal and distal ends, and blister and lid elongate sheets enclosing multiple distinct medicament dose portions therebetween. The medicament dispenser has a dispensing mechanism which is adapted to operate, upon each actuation thereof, to dispense medicament active from the medicament dose portion. Moreover, the mechanism has at least one power spring mechanism for winding the lid elongate sheet, wherein the at least one power spring mechanism has at least one spring having an inner end about which the spring unwinds, and at least one shaft at which the inner end of at least one spring is secured. Furthermore, the power spring mechanism tensions and peels a segment of lid elongate sheet peeled from a corresponding segment of blister elongate sheet upon each actuation of the medicament dispenser. Disclosed also is a method of assembling the aforementioned medicament dispenser.

Use of a substituted purine compound or a pharmaceutically acceptable salt thereof for treating one or more of autism spectrum disorder (ASD), Rett syndrome (RTT), and Fragile X syndrome (FXS). A method for treating one or more of ASD, RTT, and FXS comprising administration of a substituted purine compound or a pharmaceutically acceptable salt thereof. Use of a substituted purine compound or a pharmaceutically acceptable salt thereof in the preparation of a pharmaceutical for the treatment of one or more of ASD, RTT, and FXS. A pharmaceutical dose of a substituted purine compound or a pharmaceutically acceptable salt thereof for use in the treatment of one or more of ASD, RTT, and FXS in a subject, wherein the dose comprises 5 to 1000 mg / kg, preferably 10 to 600 mg / kg, more preferably 25 to 100 mg / kg, most preferably about 40 mg / kg of the substituted purine compound or a pharmaceutically acceptable salt thereof.

Disclosed is an elongate form medicament carrier and a medicament dispenser. The medicament carrier has a first end, a second end, and a central portion, and carrying multiple distinct medicament dose portions, the medicament dose portions consisting of a first set and a second set of medicament dose portions, the first set of medicament dose portions distributed in a first portion of the elongate form medicament carrier between the first end and the central portion of the elongate form medicament carrier and containing a medicament active, or a mixture of medicament actives, and the second set of medicament dose portions distributed in a second portion of the elongate form medicament carrier between the second end and the central portion of the elongate form medicament carrier and containing a medicament active, or a mixture of medicament actives, wherein the dose portions in the second set of medicament dose portions are different from the dose portions in the first set of medicament dose portions.

The utility model relates to the technical field of medicine production, and provides a filling machine for medicine production, which comprises a placing shell, a pressed plate is fixedly embedded on the inner surface of the placing shell, the top of the placing shell is fixedly connected with a top frame, the inner surface of the top frame is fixedly connected with a limiting rod, the outer surface of the limiting rod is movably sleeved with a limiting sleeve, and the limiting sleeve is fixedly connected with the top frame. And a movable plate is fixedly connected to one side of the limiting sleeve, a scraping plate is fixedly connected to the bottom of the movable plate, the bottom of the scraping plate is arranged on the top of the pressed plate, and an inner thread sleeve is fixedly connected to the end, away from the limiting sleeve, of the movable plate. The automatic slicking device is provided with an automatic slicking structure, so that powder or granular medicine filled in capsules can be leveled to a proper height, the medicine in each capsule is ensured to be on the same horizontal plane, the volume or weight of the medicine reaches a preset accurate dose, the large dose deviation of the medicine in each capsule is avoided, and the accuracy of the medicine in each capsule is improved. The quality and curative effect of the medicine are not influenced.

The application relates to the technical field of medical devices, and discloses an ear-nose-throat drug delivery device, which comprises a drug delivery cylinder, the inside of the drug delivery cylinder is provided with a piston and a drug outlet nozzle, the inside of the piston is provided with a push rod, the side, away from the piston, of the push rod is provided with a disc, a connecting rod is fixedly connected between the piston and the disc, the outer walls of the push rod and the connecting rod are provided with a quantitative disc, an L-shaped groove is arranged in the inside of the quantitative disc, a magnetic block one is fixedly connected to the inner wall of the L-shaped groove, a hollow cylinder is slidably connected to the inside of the drug delivery cylinder, and one end of a tension spring is fixedly connected to the inner top wall of the hollow cylinder. By pushing the disc, the magnetic block one magnetically attracts a magnetic block two, the hollow cylinder is slid in the inside of the drug delivery cylinder, the quantitative disc is limited, the quantitative drug delivery of the drug delivery cylinder is realized, the drug dose entering the ear, nose or throat cavity is kept consistent, and the drug delivery amount is prevented from being too much or insufficient due to different pressing forces or operation habits.

The invention relates to the field of chemotherapy toxicity prediction modeling, in particular to a construction method of a blood disease chemotherapy toxicity prediction model. According to the method, the dynamic metabolic coefficient of a patient to be detected is obtained according to the change of absolute neutrophil count of the patient to be detected after current chemotherapy and the albumin content and bilirubin level after current chemotherapy, and the injury coefficient of the patient to be detected is obtained according to the medication dosage and toxicity level of the patient to be detected in current chemotherapy. Obtaining a toxicity accumulation coefficient of the patient to be detected in the current chemotherapy by combining the content of the toxicity detection marker before the previous chemotherapy and the drug exposure dose of the current chemotherapy, constructing a bone marrow state vector and a liver state vector, and adjusting the liver state vector to obtain an adjusted liver state vector of the patient to be detected in the current chemotherapy; and constructing a chemotherapy toxicity prediction model by combining the multi-modal data of all patients in all historical chemotherapy periods. According to the method, the accurate chemotherapy toxicity prediction model can be established, and the chemotherapy toxicity prediction deviation is reduced.

The invention relates to the technical field of anesthetic drug control, in particular to an anesthetic drug control method and system combined with individual parameters of a patient, and the method comprises the following steps: in the process of applying anesthetic drugs, periodically applying drug dose disturbance to the patient, the medicine dosage disturbance is used for carrying out preset tiny change adjustment on the infused anesthetic; collecting physiological response data of the patient; extracting physiological response characteristics reflecting drug sensitivity or drug removal efficiency of the patient from the physiological response data; comparing the currently extracted physiological response features with historical physiological response features to generate a comparison result; adjusting pharmacokinetic parameters, used for calculating the infusion amount of the anesthetic, in the anesthetic medication control system; drug dosage disturbance is periodically applied, physiological response data of a patient are combined, physiological response characteristics are dynamically extracted and compared, and then pharmacokinetic parameters are adjusted, so that individualized and precise control over anesthetic medication is achieved.

An accessory device for use with an injection device for delivering a dose of medicament, the accessory device comprising: an attachment mechanism for releasably attaching the accessory device to the injection device, and one or more sensors configured to capture sensor data indicative of injection events during usage of the injection device, wherein the one or more sensors comprise a motion sensor configured to collect motion data indicative of movement of the attachment mechanism, and / or a sound sensor configured to collect sound data indicative of sounds generated by the attached injection device.

The invention relates to the technical field of drug dose screening, in particular to a method for screening the optimal dose of metformin for treating vascular dementia by using an OGD / R-SHSY5Y cell model, which comprises the following steps: constructing the OGD / R-SHSY5Y cell model to simulate the pathological state of vascular dementia; setting a control group, an OGD / R model group and a metformin treatment group with different concentrations, and additionally arranging a pathway inhibitor verification group; the cell proliferation activity is detected through a CCK8 method, the cell apoptosis rate is detected through an Annexin-V-FITC / PI double staining method, expression of apoptosis-related genes and key genes is detected through a qPCR method and a Western blot method, and the inflammatory factor level is detected through an ELISA method. By integrating multi-dimensional detection results, the optimal dosage of the metformin, which not only can significantly improve cell viability and inhibit cell apoptosis, but also can effectively regulate and control key gene expression and inflammatory factor balance, is screened out. Through multi-index collaborative detection and pathway mechanism verification, accurate screening of the optimal dose of the metformin for treating vascular dementia is realized.

The invention relates to the technical field of computer deep learning, and particularly discloses a computer deep learning-based curative effect prediction method and system for treating neurodegenerative diseases by a polygonatum sibiricum extract, and the method comprises the steps: S1, collecting multi-source data; s2, time sequence preprocessing and data enhancement; s3, performing self-supervised representation learning; s4, performing pharmacodynamic pharmacokinetic coupling expression learning; s5, carrying out uncertainty quantification; s6, performing anti-fact dose optimization; according to the method, pharmacokinetic parameters are coupled with cross-modal semantic vectors, and dose consistency regular terms are introduced, so that the model is forced to learn interpretable explanations of dose-reaction relationships. Samples with similar doses or similar pharmacokinetic characteristics are constrained to be in adjacent distribution in a representation space, so that model prediction not only pays attention to a curative effect result, but also can explicitly reflect an influence mechanism of the drug doses. And feature importance analysis is carried out on a single sample through an SHAP value or an attention mechanism, key driving factors related to the curative effect can be identified, and a verifiable decision basis is provided for clinicians.

A dose counting system of an injection device or of a module configured to be used with or applied to an injection device is described. The dose counting system includes a sensor arrangement including a first sensor configured to output a first signal and a second sensor configured to output a second signal; and a processor configured to: detect a peak in the first signal when the first signal has increased by at least a predefined up threshold and the first signal exceeds the value of the second signal by more than a predetermined crossover threshold; determine that a unit of medicament has been administered when the first signal drops from the peak by more than a predefined down threshold and the preceding peak occurred in the second signal; and determine a medicament dosage administered by the injection device by counting the administered units of medicament.

The invention relates to a pharmaceutical formulation comprising olaparib as active agent in solid dispersion with a matrix polymer. In particular, the present invention relates to a pharmaceutical formulation comprising olaparib in a solid dispersion with a matrix polymer that comprises polyvinylpyrrolidone, a daily pharmaceutical dose of olaparib provided by such a formulation and the use of polyvinylpyrrolidone in a solid dispersion composition with Olaparib for increasing the bioavailability and / or stability of Olaparib, and for treating cancer in a patient.

Provided herein are systems and methods for delivering medication, such as insulin, that are user-friendly, environmentally-friendly, lower cost, discreet, less prone to errors, and / or that deliver precise, repeatable doses of medication, as well as accessories for applying and managing the same. In embodiments, the system includes a wearable insulin pump having a patch-style form factor for adhesion to a user's body surface.

The present invention relates to a drug delivery device (100). The drug delivery device (100) comprises: an outer housing (1) designed to have a drug reservoir (4) installed therein; an actuating mechanism (6) designed to generate an actuating force; a dose-setting mechanism (5) installed at least partly in the outer housing (1), wherein the dosesetting mechanism (5) is capable of setting a drug dose and functionally connected to the actuating mechanism (6); an inner housing (11) installed in the outer housing (1) and functionally connected to the dose-setting mechanism (5); a rod (13) movably installed at least partly in the inner housing (11) so as to enable the drug to be discharged from the reservoir (4); a driving part (15) provided with radial teeth, wherein the driving part (15) is intermeshed in the outer housing (1) with the inner housing (11) and threadably engaged with rod (13) such that the actuating force is transferred to the rod (13) in order to move the latter depending on the set drug dose; and a cylindrical part (14) having at least one resilient element (14.1) provided with a pawl (14.2), wherein the cylindrical part (14) is secured in the outer housing (1) so as to enable the pawl (14.2) to jump at least over one of the radial teeth of the driving part (15) when rotating the driving part (15).

Analyte monitoring systems and methods for on-body sensor control devices are capable of sensing two or more analytes in a patient and include a processor and memory with instructions for determining various machine states and outputs based on time-correlated sensor data for each analyte. The states and outputs may include warning conditions, advisory messages, corrections to analyte status estimates, indications of sensor control device failure, insulin delivery device failure, drug dose calculations, or analysis reports for one or more analytes. An example system and method is described for dual analytes including glucose and ketones. Data may be transmitted from the sensor control device to a reader for output to a user.

The present invention relates to a system for measuring and managing the injection volume of a pen-type injection device using a stepper motor. The system for measuring and managing injection volume is mounted on a non-protruding pen-type injection device (1) to measure the injection volume of a drug. The system (100) for measuring and managing the injection volume of a pen-type injection device using a stepper motor comprises: a main body (110) detachably mounted on an injection device housing (10) of the pen-type injection device (1); a dose sensing module (120) including a dose setting knob contact wheel (121) and a stepper motor (125); a main control unit (130) for calculating the rotation angle of the dose setting knob (12); and an input / output interface (140) which is connected to the main control unit (130), receives a manipulation required for operation, and displays an operation state. The main control unit (130) acquires a drug dose calculation value through the calculated rotation angle of the dose setting knob (12), and then manages and displays the drug dose calculation value as injection history information.