11 results about "Dose-Limiting" patented technology

The invention provides a three-dimensional model establishing method and device and a radiotherapy system. The method comprises the steps of obtaining a target area based on a medical image; defining a material of a voxel unit in the target area based on a target template in a material template library matched with the target area, wherein matchable candidate templates in the material template library comprise a homogeneous material template and a heterogeneous material template; and establishing a three-dimensional model based on the material of the voxel unit in each target area. According to the scheme, different image qualities of medical images and differences of tissues and organs of individual patients are considered, and the material of each voxel unit in each target area is defined in a more targeted manner by adopting different strategies through matching the target templates, so that the three-dimensional model is established by using a more suitable material; the model is closer to the real tissue and organ characteristics of the patient, so that the treatment plan can more accurately evaluate the dose limit and the tumor specified dose of the normal tissue.

The invention provides a pelvic tumor multi-center, multi-tumor-species and multi-prescription dose prediction method and related equipment, and is applied to the technical field of data processing. The method comprises the following steps: preprocessing a training sample set to generate a training sample set with target feature data; processing a preset dose distribution processing model based on a SwinTransform network architecture based on the training sample set with the target feature data, and generating a target dose distribution processing model; performing feature extraction processing on the CT image information of the target user to generate a target feature vector; processing the physiological state information of the target user to generate a dose limiting factor of the target user; processing the physiological parameter information of the target user to generate a dynamic dose influence factor of the target user; and processing the target feature vector, the dose limiting factor of the target user and the dynamic dose influence factor of the target user based on a target dose distribution processing model to generate target dose distribution information.

The present application discloses pharmaceutical compositions and methods of treating neurological disorders and seizure disorders with the high dose modified release compositions of huperzine. The pharmaceutical compositions and methods described herein, allow for higher dosing of huperzine, while avoiding rapid peak plasma levels, thereby avoiding the dose-limiting adverse events associated with the immediate release formulations.

Disclosed in the present invention is an adjustable autoinjector, comprising: a main shaft rotatably provided in a pen body, wherein a push rod assembly is provided in the main shaft; a dose knob used for dose setting and dial-back, and configured to: during dose setting, drive the main shaft to rotate and allow for energy storage of an energy storage assembly, wherein the energy storage assembly is fitted over the main shaft; a connecting assembly provided at the lower portion the main shaft, and configured to: limit reverse rotation of the main shaft when a dose has been set, release the limitation on the reverse rotation of the main shaft when the dose knob rotates reversely due to over-setting of the dose, and be disconnected from the main shaft during injection; a dose limiting assembly provided in the dose knob and configured to prevent a set total dose from exceeding the total dose of liquid medicament; and the energy storage assembly comprising a spiral spring. In the adjustable autoinjector of the present invention, the main shaft is rotatably provided in the pen body; the energy storage assembly is provided on the main shaft; the dose knob is used for dose setting and allowing for energy storage of the energy storage assembly; during injection, the spiral spring drives the main shaft to rotate and provides torque suitable for high-viscosity liquid medicament; and when the dose is set excessively, a dial-back operation can be performed.

The present disclosure relates to a dose limiting mechanism (100) for an injection device (1), the dose limiting mechanism (100) being configured to be arranged inside a housing (3) of the injection device (1) and being operable to limit a total number of doses dispensable by the injection device, the dose limiting mechanism (100) comprising: - a first elongated member (110) extending in a longitudinal direction and comprising a first profile structure (112), - a second elongated member (120) coaxial or parallel to the first elongated member (110) and comprising a second profile structure (122) facing the first profile structure (112), - a dose limiter (130) arranged between the first elongated member (110) and the second elongated member (120), the dose limiter (130) comprising a first profile section (131) and a second profile section (132), - wherein the first profile section (131) is engageable with the first profile structure (112) to transmit a longitudinal movement of the first elongated member (110) to the dose limiter (130) when the first elongated member (110) is longitudinally moved in a distal direction relative to the second member (120) during dose dispensing, and - wherein the second profile section (132) is engageable with the second profile structure (122) to maintain a longitudinal position of the dose limiter (130) relative to the second member (120) when the first member (110) is longitudinally moved in a proximal direction relative to the second member (120).

Provided in the present description are a method and apparatus for establishing a three-dimensional model, and a radiotherapy system. A target region is acquired on the basis of a medical image; the material of each voxel unit in the target region is defined on the basis of a target template in a material template library matched with the target region, wherein a candidate template available for matching in the material template library includes a homogeneous material template and a heterogeneous material template; and a three-dimensional model is established on the basis of the material of each voxel unit in each target region. In this solution, differences in image quality of medical images and variations in tissues and organs of individual patients are taken into consideration. By matching a target template, the material of each voxel unit in each target region is more specifically defined by using a different strategy, so as to establish a three-dimensional model using the more suitable material. The model more closely resembles actual characteristics of tissues and organs of patients, such that treatment plans can more accurately evaluate dose limits for normal tissues and prescribed doses for tumors.

Disclosed in the present invention is a dose-limiting assembly for injection, comprising a dose knob, wherein the dose knob is rotatably arranged on a force storage spring assembly; a fixed gear is fixedly arranged on an upper portion of the force storage spring assembly; a limiting gear is rotatably arranged inside the dose knob; and the limiting gear meshes with the fixed gear. During dose setting, the dose knob is rotated to drive the limiting gear to rotate; and during injection, the positions of the limiting gear, the fixed gear and the dose knob remain unchanged, and when a cumulatively set dose of the dose knob reaches the predetermined maximum dose, the limiting gear restricts the dose knob from rotating. In the dose-limiting assembly for injection of the present invention, the limiting gear is arranged between the force storage spring assembly and the dose knob, and when the dose knob is rotated by a maximum dose-setting number of turns, the limiting gear restricts the dose knob from rotating, so as to prevent a set dose for the last injection from exceeding a remaining dose of a medicinal liquid, thereby preventing harm to the health of a patient caused by the inaccurate amount of an injected drug.

The invention provides a dose prediction method and device, equipment and a medium, and the method comprises the steps: obtaining a medical image of a target object; wherein the medical image comprises a target region, an organ at risk and a target part; based on the medical image, segmenting the target region and the endangered organ, and generating a target region segmentation result and an endangered organ segmentation result; and predicting prescription dose parameters of the target object based on the medical image, the target region segmentation result and the endangered organ segmentation result. By applying the embodiment of the invention, the reasonable prescription dose parameter can be formulated based on the medical image of the target object in combination with the target region segmentation result and the endangered organ segmentation result without depending on the experience of a doctor, so that the objectivity and consistency of the prescription dose parameter are ensured. Moreover, the formulated prescription dose parameters comprise dose limiting ranges corresponding to different areas in the target part, so that targeted protection of the target part can be realized, and the risk of radioactive injury is reduced.

The application discloses a kind of prevention vaccination vaccine precision suction injection auxiliary device, including extraction auxiliary cylinder, extraction dose limiting mechanism, clamping support mechanism and dose observation mechanism, extraction auxiliary cylinder other side hinged rotation open and close, extraction auxiliary cylinder top middle is fixed with threaded sleeve, threaded sleeve is equipped with screw inside screw thread cooperation, recess is opened symmetrically in extraction auxiliary cylinder upper side, screw lower end bearing is equipped with lifting limiting plate, lifting limiting plate is fixed with sliding sleeve on two sides symmetrically, sliding sleeve is equipped with sliding rod, screw upper end is equipped with locking mechanism, extraction auxiliary cylinder lower side is equipped with clamping support mechanism, extraction auxiliary cylinder outside is equipped with dose observation mechanism;The present application realizes stepless adjustment syringe extraction dose by the precision cooperation of threaded sleeve and screw, solves the problem of insufficient precision of traditional mechanical device, solves the dependence on electricity by manual pressing auxiliary suction, and adapts to diversified application scenarios.

The present invention describes the use of a 5HT3-antagonist, in combination with a 6-propylamino-4,5,6,7-tetrahydro-1,3-benzothiazole-2-amine, to reduce adverse 5 effects and to facilitate the neuroprotective treatment of a patient suffering from a synucleinopathic disorder to enable a therapeutically effective 6-propylamino- 4,5,6,7-tetrahydro-1,3-benzothiazole-2-amine daily dose without the dose-limiting adverse effects caused by pramipexole when administered alone. 10 80 20 24 20 41 67 19 J un 2 02 4 2 0 2 4 A B S T R A C T 2 0 2 4 2 0 4 1 6 7 1 9 J u n 1 0

Machine learned neural networks or machine learning algorithms may be used in a variety of healthcare methods and systems, such as those relating to drug delivery, drug therapies, and / or infusion pumps. The machine-learned neural networks may receive and process data to provide one or more outputs, such as recommended dose limit settings, potential adverse events, medication misuses, occlusion occurrences, extravasations and / or disconnections, pump failures, and maintenance needs. The machine learning algorithms may be trained on a corpus of relevant data to identify recommended dose limit settings, potential adverse events, medication misuses, occlusion occurrences, extravasations and / or disconnections, pump failures, and maintenance needs.