34 results about "Dose-Limiting" patented technology

The present invention relates to a dose setting mechanism intended to be used in a medicament delivery device, comprising an elongated tubular distal housing (16) having opposite distal and proximal ends, wherein said distal housing comprises threads (14) on its inner surface, a first window (30), a second window (32), and at least one opening (38) on its elongated surface; a tubular dose limiting member (10) having opposite distal and proximal ends, wherein said dose limiting member comprises a first thread segment (12) on its outer circumference surface at its proximal end intended to cooperate with corresponding threads on the inner surface of the distal housing, first indicia (18) on its outer circumferential surface, a stop surface (42) at its proximal end, and a number of protrusions (20) arranged equidistant to each other along the circumference on the outer surface at its distal end; a tubular dose setting member (22) having opposite distal and proximal ends, wherein said distal housing is coaxially arranged inside the dose limiting member and comprises a second thread segment (24) having and end surface (44) on its outer circumferential surface at its proximal end intended to cooperate with the threads of the distal housing, second indicia (26) on its outer circumferential, and a dose setting knob (28) protruding through the distal end of the distal housing; and a removable lock member (36) attached to the distal housing, wherein said lock member comprises at least one elongated rib (40) on its inner circumferential surface which is intended to interact with the protrusions of the dose limiting member for locking the dose limiting member in a certain position when the lock member is attached to the distal housing.

A syringe configured with a limited maximum usable capacity. The syringe of the invention desirably has a retractable needle to prevent reuse. In the preferred embodiment, a dose-limiting structure includes a stop-ring member on the head of the plunger that abuts a constriction in the housing when the plunger is moved away from the needle to prevent the further rearward movement of the plunger. Preferably, the syringe of the invention is configured such that a user is tactilely signaled when the plunger has reached a position corresponding to a nominal fixed-dose. If the user attempts to force the stop-ring member beyond the constriction, the plunger seal is stripped off or removed from the plunger head and the syringe rendered inoperable. The features of the invention can also be applied to a nonretracting syringe.

Racemic norketotifen, racemic 10-hydroxy-ketotifen, racemic 10-hydroxy-nor-ketotifen and optically active isomers of ketotifen, norketotifen, 10-hydroxy-ketotifen and 10-hydroxy-norketotifen were found to have antiallergic and anti-inflammatory effects while being devoid of the severe dose-limiting sedative side effects of Ketotifen.

The present invention relates to a medicament delivery device (100) having a a drive mechanism arranged to drive a plunger rod (12). A last dose limiting mechanism is arranged to interact with the drive mechanism and limit the distal end position of an actuator (3) when the plunger rod (12) has reached a pre-determined position between its distal end position and its proximal end position.

Disclosed is a method and composition for treating a disease associated with target cells expressing CD138 in a multiple dose regimen. An immunoconjugate comprising an engineered targeting antibody targeting CD138 expressing cells and an effector molecule is administered in a multiple dose regimen. The multiple dose regimen comprises at least two doses and the aggregate dose administered within an active treatment cycle is an aggregate maximum tolerable dose (AMTD) or a fraction of the AMTD. The AMTD and / or said fraction exceeds the dose resulting in dose limiting toxicity (DLT) and / or exceeds the maximum tolerable dose (MTD) when the immunoconjugate is administered as a single dose, including as part of a multiple single dose regimen within said active treatment cycle.

The present invention relates to a medical injection system comprising a medical injection device (100) of the type comprising a rotatable dose setting member (160). The system further comprises a dose limiter module (200) adapted for being releasably coupled to the injection device (100). The dose limiter module (200) comprises a dose limiter base (201) and a limiter (240) arranged relative to the dose limiter base (201) so that their relative position is adjustable to set an adjusted dose limiting position. When the dose limiter module (200) is coupled to the injection device (100), the limiter (240) cooperates with the dose setting member (160) to define a blocking means for preventing rotation of the dose setting member (160) beyond the adjusted dose limiting position. The dose limiter module (200) further comprises a user operable lock (210,212,232,223,243) configured for operation between a locked state and an unlocked state to respectively prevent and enable modification of the adjusted dose limiting position, the lock (210,212,232,223,243) being configured for maintaining the lock in the locked state at least when the dose limiter module (200) is not coupled with the injection device (100).

The present invention describes the use of a 5HT3-antagonist, in combination with a 6-propylamino-4,5,6,7-tetrahydro-1,3-benzothiazole-2-amine, to reduce adverse effects and to facilitate the neuroprotective treatment of a patient suffering from a synucleinopathic disorder to enable a therapeutically effective 6-propylamino-4,5,6,7-tetrahydro-1,3-benzothiazole-2-amine daily dose without the dose-limiting adverse effects caused by pramipexole when administered alone.

The invention discloses a traditional Chinese medicine combined preparation for treating radiation esophagitis, which is composed of honeysuckles, mint, fructus forsythiae, radix ophiopogonis, bamboo leaves, liquorice, smoked plum, radix rehmanniae, pericarpium citri reticulatae, pseudo-ginseng powder, borneol and honey. The preparation has the effect that when a patient suffered from chest or head and neck malignant tumor receives radiotherapy, dose-limiting reactions, such as congestion, edema, erosion or inflammatory exudative change and even anabrosis, in mucous membrane of esophagus. The traditional Chinese medicine combined preparation can alleviate even cure these symptoms so that the radiotherapy on the patients can be completed with significant treatment effect. The preparation is prepared through a water-decoction extraction process so that the characteristic of original taste of a traditional Chinese medicine decoction and effective components are free from losing. In addition, the retention time of the decoction in mucous membrane of esophagus is prolonged, thereby improving clinical curative effects.

The present application discloses pharmaceutical compositions and methods of treating neurological disorders and seizure disorders with the high dose modified release compositions of huperzine. The pharmaceutical compositions and methods described herein, allow for higher dosing of huperzine, while avoiding rapid peak plasma levels, thereby avoiding the dose-limiting adverse events associated with the immediate release formulations.

The present application discloses pharmaceutical compositions and methods of treating neurological disorders and seizure disorders with the high dose modified release compositions of huperzine. The pharmaceutical compositions and methods described herein, allow for higher dosing of huperzine, while avoiding rapid peak plasma levels, thereby avoiding the dose-limiting adverse events associated with the immediate release formulations.

The invention belongs to the technical field of solid waste treatment, and discloses a radioactive solid waste detecting and classifying method. The method comprises the steps of: measuring a surface dose level, a pollution nuclide type and a radioactive specific activity of a radioactive solid waste sample; obtaining a fitting curve of the dose level and the radioactive specific activity, building a function relation of the two, and determining a dose limiting value range of the radioactive solid waste in a different-pollution-grade state; measuring a dose level of the radioactive solid waste; and comparing the dose level of the radioactive solid waste with the dose limiting value range thereof in the different-pollution-grade state, judging the pollution grade of the radioactive solid waste, and classifying and collecting the radioactive solid waste. The method compares the dose level of the radioactive solid waste with the dose level limiting value range through building the relation between the radioactive solid waste pollution grade and the dose level limiting value range, so that the pollution grade can be quickly judged, the classification and the collection are realized, and the treatment and management capacity of the radioactive solid waste is greatly promoted.

The present invention relates to a medical injection system comprising a medical injection device (100) of the type comprising a rotatable dose setting member (160). The system further comprises a dose limiter module (200) adapted for being releasably coupled to the injection device (100). The dose limiter module (200) comprises a dose limiter base (201) and a limiter (240) arranged relative to the dose limiter base (201) so that their relative position is adjustable to set an adjusted dose limiting position. When the dose limiter module (200) is coupled to the injection device (100), the limiter (240) cooperates with the dose setting member (160) to define a blocking means for preventing rotation of the dose setting member (160) beyond the adjusted dose limiting position. The dose limiter module (200) further comprises a user operable lock (210,212,232,223,243) configured for operation between a locked state and an unlocked state to respectively prevent and enable modification of the adjusted dose limiting position, the lock (210,212,232,223,243) being configured for maintaining the lock in the locked state at least when the dose limiter module (200) is not coupled with the injection device (100).

The present invention relates to a drug delivery device for selecting and dispensing a plurality of user-variable doses of a medicament comprising a dose limiter for preventing the set dose from exceeding the amount of liquid remaining in a cartridge of the drug delivery device. The device comprises: a housing (10, 20), a dose selector (140) for selecting a dose by rotation relative to the housing (10, 20), a dosing element (40, 130), and a releasable clutch (45 , 143), the releasable clutch (45, 143) is used to couple the dose selector (140) to the dosing element (40, 130) in rotation during dose selection and to make the dosing element (40, 130) are rotationally disengaged from the dose selector (140). The clutch includes a male spline (45), a corresponding female spline (143), and is oriented such that re-engaging the clutch will direct the male spline (45) to a predetermined rotation relative to the female spline (143) Orientation of curved or sloped surfaces (142).