41 results about "Body surface area" patented technology

The invention relates to the field of medical information management, in particular to a children malignant tumor treatment process and follow-up visit electronic management system and a children malignant tumor treatment process and follow-up visit electronic management method. The method comprises the steps that the body surface area of a patient is calculated, and the chemotherapy drug dosage in each cycle is calculated based on the body surface area of the patient; performing cycle-by-cycle accumulation on the chemotherapeutic drug dose in each cycle to obtain an actual accumulated dose; calculating and standardizing the specific numerical value of each curative effect index based on the actual accumulated dose, and calculating a comprehensive therapeutic effect score by combining the importance weight of each curative effect index; and calculating the disease-free survival rate based on the actual accumulated dose and the comprehensive treatment effect score. The problems that at present, most medicine dosage calculation methods neglect the special physiological features of children, a treatment monitoring system lacks dynamic adjustment support in the treatment process, a follow-up management system is insufficient in quantitative analysis capacity for long-term prognosis, and personalized long-term health management suggestions cannot be provided for patients are solved.

The invention belongs to the field of lung medical data processing and radiotherapy, and discloses a respiratory feature extraction method for chest and abdomen body surface point cloud partitioning by considering a lung physiological structure. After the body surface point cloud image is differentiated, correlation coefficient calculation is carried out according to a lung lobe model reconstructed by a lung 4DCT image, a body surface area highly correlated with a lung lobe structure is selected to carry out motion information dimension reduction recombination, and finally body surface global features of breathing are represented in a three-dimensional vector form. Compared with the prior art, the method has the advantages that the influence of the lung physiological structure on the lung tumor movement mode is creatively considered, meanwhile, the advantages of being noninvasive and free of extra dosage are kept, a new thought can be provided for development of the radiotherapy image guide technology, and further research in the field of thoracic and abdominal activity tumor radiotherapy is facilitated.

The invention discloses a self-adaptive fitting ultrasonic probe flexible accessory which comprises a flexible cover sleeve body, and the flexible cover sleeve body is made of a medical-grade elastic material and is provided with a containing cavity matched with an ultrasonic probe in shape; the sealing opening is formed in the bottom of the flexible cover sleeve body and is used for tightly wrapping the emitting surface of the probe; the liquid storage cavity is a closed cavity and is pre-filled with a high-viscosity medical ultrasonic coupling agent; the self-adaptive attaching layer is composed of the bottom wall of the flexible cover sleeve body. Wherein the liquid storage cavity is located between the sealed opening and the self-adaptive attaching layer, and the coupling agent is evenly distributed on the contact interface of the probe and the skin under the action of pressure; the probe is matched with a common ultrasonic probe, and the imaging effect of the probe in an uneven body surface area is improved on the premise that the main body structure of the probe is not changed.

A system (100), method (600) and non-transitory computer-readable medium are described for performing ultrasound imaging. The method (200) includes: receiving images from a camera (602); reconstructing a body surface map from the images from the camera (604); applying a first trained computational model to the body surface map to predict a body type (606); applying a second trained computational model to predict a pose of the body (608); andidentifying, on the body surface map, a portion of the body to be obscured, and a portion of the body to be imaged (610) during the ultrasound imaging method.

Topical compositions and methods for using topical compositions comprising tapinarof to treat mild to moderate atopic dermatitis or plaque psoriasis are described herein. Also described are clinical endpoints for treatment of subjects diagnosed with mild to moderate atopic dermatitis, wherein about 5% to about 35% of body surface area was affected, and Investigator Global Assessment (IGA) score was greater than or equal to 3. Also described are clinical endpoints for treatment of subjects diagnosed with chronic mild to moderate plaque psoriasis for greater than or equal to 6 months, wherein about 3% to about 20% of body surface area was affected, and Physician Global Assessment (PGA) score was greater than or equal to 2.

This invention discloses a method for detecting the toxicity threshold of a substance based on a rat drinking experiment. The method of this invention includes the following steps: First, a drinking preference experiment is conducted, and then the toxicity threshold is determined: the amount of substance water and pure water consumed in the drinking preference is compared to determine the time when the rat begins to significantly avoid substance water, the mass of the toxic substance in the rat's body at that time is calculated, and the toxicity threshold of the rat is calculated; (3) dose conversion from rat to human: based on the interspecies dose conversion of body surface area, the toxicity threshold of the rat is first converted into the equivalent dose for humans to obtain the acute exposure dose, and then the acute exposure dose is converted into the chronic exposure dose for humans to obtain the substance toxicity threshold. This invention can accurately determine the toxicity threshold: it achieves toxicity assessment of low-dose exposure through spontaneous recognition behavior; it is easy to operate; and it is applicable to the toxicity assessment and non-destructive threshold determination of various substances such as environmental pollutants, chemical substances, and drugs.

The present invention provides a control system and method for personalized treatment of a left ventricular assist device, relating to the field of artificial heart technology. The method comprises: for each cardiac cycle, a Starling-like regulator receives a left atrial pressure signal fed back by a physiological feedback module, and outputs a desired cardiac index based on the patient's body surface area; a pump flow quantification feedback module calculates the pump flow in real time based on the rotational speed and current of the left ventricular assist device, and outputs the feedback cardiac index in combination with the patient's body surface area; calculates the deviation between the desired cardiac index and the feedback cardiac index, inputs the deviation into a controller, and the controller determines the output current increment based on the deviation; and repeats the above process until the control system stabilizes. Ventricular pressure is monitored by the physiological feedback module and the cardiovascular coupling module, and personalized physiological characteristics analysis is performed in combination with the patient's body surface area, so that the pump speed parameters can be automatically optimized according to the patient's real-time physiological state.

The invention relates to an air conditioner and a control method thereof. The air conditioner comprises an indoor unit and an outdoor unit. The first sensing sensor is used for collecting environment data of a target environment; the second perception sensor is used for identifying the target state of the target object; the first temperature sensor is used for collecting the environment temperature of the target environment; the controller is used for extracting a body surface area and a bedding coverage area from the environmental data under the condition that the sleep guarding mode is started and the target object is in a sleep state; taking the area proportion of the bedding coverage area in the body surface area as the bedding coverage rate; according to the bedding coverage rate, determining a cold catching risk grade of the target object; according to the cold catching risk grade, the target age group of the target object and the working state of the indoor unit, the target temperature and the target air speed type of the air conditioner are determined; and the indoor unit and the outdoor unit are controlled, and the environment temperature is adjusted to the target temperature according to the target air speed type. By means of the air conditioner, the risk of catching cold can be lowered in a targeted mode.

To provide methods of treating a disorder characterized by pathological activity of CD30+ cells, such as in certain solid, hematological and lymphoid cancers, in a non-adult human subject by administering an effective amount of an anti-CD30 ADC (antibody drug conjugate), such as, Brentuximab Vedotin, to the subject.SOLUTION: The invention is based, at least in part, on applicant's discovery that a body surface area (BSA)-adjusted dose of an anti-CD30 ADC provides a more consistent exposure to the ADC across non-adult human subjects compared to weight-adjusted doses of an anti-CD30 ADC, as assessed by area under the curve (AUC).SELECTED DRAWING: None

The present invention relates to pharmaceutical compositions and methods for the treatment of carcinomas and sarcomas. In particular, the invention provides a pharmaceutical composition comprising a peptide or pharmaceutically acceptable salt thereof for use in treating a carcinoma or a sarcoma in a human subject, wherein the peptide comprises an amino acid sequence as set forth in SEQ ID NO: 1 and a cell penetrating peptide and wherein the pharmaceutical composition is systemically administered to the subject weekly to provide a dose of the peptide of about 15-65 mg / m2 body surface area (BSA) per week, calculated as the free form of the peptide.

To provide an endothelial function index value measuring device of an arterial blood vessel capable of quickly acquiring an endothelial function index value capable of evaluating an endothelial function.SOLUTION: A cross-sectional image is generated from reflected ultrasonic signals obtained by the ultrasonic probe 24 on the skin 18, the biceps muscle cross-sectional area MCSA is calculated from the muscle image area GKN of the biceps muscle in the cross-sectional image, the biceps muscle mass MCSAI (= MCSA / BSA) is calculated from the biceps muscle cross-sectional area MCSA and the body surface area BSA, and the endothelial mass index MHI (= MCSAI / MB) is calculated from the biceps muscle mass MCSAI and the muscle brightness MB of the muscle image area GKN.SELECTED DRAWING: Figure 1

Topical compositions and methods for using topical compositions comprising tapinarof to treat mild to moderate atopic dermatitis or plaque psoriasis are described herein. Also described are clinical endpoints for treatment of subjects diagnosed with mild to moderate atopic dermatitis, wherein about 5% to about 35% of body surface area was affected, and Investigator Global Assessment (IGA) score was greater than or equal to 3. Also described are clinical endpoints for treatment of subjects diagnosed with chronic mild to moderate plaque psoriasis for greater than or equal to 6 months, wherein about 3% to about 20% of body surface area was affected, and Physician Global Assessment (PGA) score was greater than or equal to 2.

The invention discloses a manufacturing method and system of a customizable medical dressing, and belongs to the technical field of medical instrument manufacturing. In order to solve the problems that an existing medical dressing is difficult to fit a complex body surface area and the customization efficiency is low, the technical means of rapid three-dimensional scanning, flexible demand modeling, paper folding pattern generation, laser engraving processing and the like are mainly adopted, automatic identification of different body surface contours, flexible scoring and dynamic generation of structural patterns are achieved, and the customization efficiency is high. And precise engraving and cutting of the dressing are completed through an automatically-controlled laser system. According to the method, rapid personalized customization of the medical dressing can be realized, and the fitting degree and the covering precision are improved.

1. Name of the product in this design: Body Surface Area Recording Board. 2. Purpose of this design: For use as a body surface area recording board for chemotherapy in cancer patients. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention relates to a natural polymer bioelastomer tissue compensator for tumor radiotherapy and a preparation method and application thereof, and the tissue compensator is composed of natural polymer and plasticizer and can be applied to tumor radiotherapy. Compared with the prior art, the tissue compensator has the advantages that by adopting the natural polymer bioelastomer material, the adaptability, dosage accuracy, clinical operation convenience, cost effectiveness and the like of an irregular body surface area are obviously superior to those of an existing tissue compensator; the tissue compensator has the advantages that the tissue compensator has excellent morphological adaptability and good biocompatibility and degradability, and is combined with a personalized preparation process, so that the dosage uniformity and the treatment effect of radiotherapy are improved, and the medical cost and the environmental burden are reduced.

The invention relates to the technical field of biomedical engineering and medical monitoring, and discloses a doxorubicin pharmacodynamics monitoring and toxicity early warning system based on optical sensing signals. Comprising a detection presetting module used for stably depositing a human serum albumin receptor system on a detection medium through an electrochemical method to realize presetting of a peripheral subcutaneous mesenchymal baseline environment and a detection limit; the range determination module is used for determining the main field intensity range of a fluorescence signal excited by the adriamycin by using an excitation LED with the wavelength of 350-400 nm and a cut-off light filtering device; the variation acquisition module is used for acquiring the variability of the finger tip blood oxygen data and the wearable electrocardiogram data; and the reference generation module is used for determining a target of single administration dosage according to the body surface area or body weight, monitoring the level of subcutaneous interstitial residual free adriamycin after multiple times of administration, and generating reference information of skin accumulated toxicity.

A compound of formula Ior a pharmaceutically acceptable salt or ester thereof is provided for the treatment of cancer wherein(i) the cancer is one that has the characteristic of being a type prone to being or becoming refractory or resistant to platinum drug based therapy and(ii) the treatment is with a dose of between 1 mg / m2 and 30 mg / m2 of compound per patient body surface area per administration.Method of treatment and novel dosage forms are also provided.Particularly treated are ovarian cancers, particularly those expressing α-folate receptors, including epithelial ovarian, fallopian tube or peritoneal cancer.

The present invention discloses a method for constructing an animal inflammatory model of psoriasis with different severities of skin lesions, comprising the following steps: raising 30 Balb / C mice according to a standard feeding method; weighing and calculating the body surface area of ​​each mouse at baseline D0, and removing the hair of the mice; randomly dividing the 30 Balb / C mice into three groups according to the lesion area, namely a mild group, a moderate group and a severe group; using 5 mg / cm 2 Imiquimod was evenly applied to the lesion area of ​​each mouse; the mice were killed after 7 days of intervention, and the skin tissue and spleen of the mice were taken for subsequent examination. The changes in the skin lesions of the mice were recorded by taking photos with a camera. After 7 days of treatment with imiquimod cream, typical psoriasis-like lesions appeared. The constructed psoriasis animal model has very similar clinical symptoms to psoriasis patients, can show psoriasis-related histological changes and immune system changes, and can be used to screen psoriasis treatment drugs.

The present invention relates to a method and system for predicting human metabolic rate based on indoor and outdoor air composition, which obtains the fresh air volume entering the indoor space, the number of people in the indoor space, and the height and weight corresponding to each person; obtains the concentration of a set gas, air temperature, and atmospheric pressure in the indoor and outdoor environments; converts the concentration of the set gas through unit conversion, and combines it with the air temperature, atmospheric pressure, and molecular weight of the set gas to obtain the density of the set gas. Based on the indoor pollutant diffusion equation, the production rate of the set gas by the human body in the indoor space is obtained and corrected to a value under standard conditions; according to the height and weight corresponding to the person, the body surface area of each person is obtained, and using the production rate and respiratory quotient of the set gas under standard conditions, the metabolic rate is determined based on the indirect calorimetry method, and after time-phase correction, the final human metabolic rate is obtained.

A burn assessment chart, method of generation, and system is provided. The chart includes a front profile and a rear profile corresponding to front and rear human profiles, including a head, two arms and two legs. The chart includes longitudinal lines and lateral lines that intersect within either the front or rear profile to form segments that correspond to a percentage of a human's surface area (e.g., 1%, 0.5%, etc.). The segments can be marked at locations that correspond to burn indicators on a patient, and the marked segments counted to easily determine a total percentage of surface area of a human that is burned.

The invention discloses a clinical test drug dosage increasing system and method.The clinical test drug dosage increasing system comprises a fixed dosage increasing method end, a body surface area adjusting method end, an individual response adjusting method end and a Bayesian dosage increasing method end; the fixed incremental dose method end, the body surface area adjustment method end, the individual response adjustment method end and the Bayesian incremental dose method end are in data communication. According to the method, researchers can be helped to quickly and accurately determine a drug dosage scheme, and the safety and effectiveness of drugs in the test process are ensured. And corresponding selection and adjustment can be carried out according to factors such as actual test purposes, testee groups and drug characteristics, so that test requirements are met, and selection of drug doses is optimized.

The invention relates to the technical field of medical positioning, and discloses an intelligent acupoint positioning method and system based on multi-modal imaging, and the method comprises the steps: carrying out the dual-modal feature decoupling of infrared thermal imaging data and ultrasonic elastography data of a target patient, and obtaining a feature waveform set; matching the characteristic waveform set with a corresponding acupuncture point initial position mark point set in a preset acupuncture point waveform template library; projecting the acupuncture point initial position mark point set to a body surface area corresponding to the target patient, and performing distortion correction on acupuncture point projection to obtain a high-precision acupuncture point coordinate set; mapping the high-precision acupoint coordinate set to a three-dimensional space to obtain a three-dimensional acupoint model; performing real-time parameter registration on the three-dimensional acupuncture point model based on the real-time physiological state of the target patient to obtain a standard space parameter set of the three-dimensional acupuncture point model; and superposing the standard space parameter set to the three-dimensional acupoint model to obtain a visual acupoint view. According to the invention, the accuracy of intelligent acupoint positioning of multi-modal imaging can be improved.

Disclosed herein are systems and methods for diagnosing skin diseases and / or determining an appropriate treatment. The systems and methods are operable to determine a body surface area of a patient based on one or more images of the patient, apply one or more masks to determine the affected areas of the body surface area, provide a diagnosis based on a calculated percentage of affected areas in relation to the body surface area of the patient, and determine a treatment based on the diagnosis.

The invention relates to the technical field of medical hyperbaric oxygen chamber control, in particular to a stepped pressurization mode for a medical hyperbaric oxygen chamber, which comprises the following steps of: acquiring a heart rate variability basic value, a respiratory rate baseline value and individual physiological characteristic parameters of body surface area of a user, analyzing preset target treatment pressure, and determining the target treatment pressure; and generating a staged pressurization rate set containing the multi-stage pressure increasing rate and the corresponding target pressure sub-value through a preset stepped pressurization strategy model. After pressurization is started, the real-time heart rate variability and respiratory rate of a user are collected in real time, the pressurization rate of the current stage is adjusted according to dynamic physiological data in each pressure increasing stage, and after the pressure in the cabin reaches a target pressure sub-value, the next stage is started until the target treatment pressure is reached. According to the mode, stage pressurization parameters are customized by combining individual physiological characteristics, and the pressurization rate is dynamically regulated and controlled by real-time physiological data to adapt to the physiological state of a user.

The utility model provides a kind of three-dimensional human body model of spinal nerve innervation body surface area, specifically related to human anatomy and neurology research technical field.Aiming at two-dimensional display mode and light interference and other problems, the utility model provides a kind of three-dimensional human body model of spinal nerve innervation body surface area, including three-dimensional human body model ontology, three-dimensional human body model ontology is divided into multiple spinal nerve innervation areas, adjacent spinal nerve innervation area is separated by light-tight partition, and each spinal nerve innervation area is provided with luminous body at its sensory key point.The device enables learners to more intuitively understand and remember the distribution and function of spinal nerves.

The present invention provides a method for continuously monitoring the coupling quality of a coupling interface between an acoustic energy source of a treatment device and a body surface area of a patient, comprising the steps of: (f) acquiring a plurality of images of at least one predetermined first region of the coupling interface; (g) extracting at least one first image feature of a predetermined first image of the plurality of images; (h) extracting the at least one first image feature of at least one second image of the plurality of images, the at least one second image being temporally spaced apart from the predetermined first image; (i) determining a quantitative parameter corresponding to a difference between the at least one first image feature of the predetermined first image and the at least one first image feature of the at least one second image, and (j) enabling a signal if the quantitative parameter exceeds a predetermined reference threshold.

A clinical care system that integrates and analyzes patient data and applies rules to recommend potential treatments. A potential application is detection and management of shock, using hemodynamic data collected from devices such as a right heart catheter. The system may calculate confidence levels for each rule and present high-ranked treatment options to clinicians along with their confidence levels. Confidence levels for treatments may change continuously as a patient's condition evolves. For shock, features extracted from measured data may include for example a cardiac index (cardiac output divided by patient body surface area), systemic vascular resistance, and mean arterial pressure; treatment recommendations derived from these (and other) features may include administration of various medications such as epinephrine and vasopressin, installation of a ventricular assist device, transfusion, and volume resuscitation. Machine learning may be used to match recommendations to current clinical practice, or to optimize patient outcomes.

The invention relates to the technical field of medical treatment, and discloses a radiotherapy body position adjusting method, device and system based on millimeter wave radar, and the method comprises the steps: obtaining target millimeter wave echo data of a body surface region covered by a fixed film in a state that the body surface of a patient is covered by the fixed film; according to the target millimeter wave echo data, an actual three-dimensional model reflecting the actual body position of the patient is generated; a reference three-dimensional model of the standard body position of the patient is obtained; the actual three-dimensional model and the reference three-dimensional model are registered, and the pose deviation and the positioning confidence coefficient of the current body position of the patient relative to the standard body position are determined; and according to the pose deviation and the positioning confidence coefficient, generating a body position adjustment guide instruction or prompt information of the patient. According to the technical scheme, the problem that in the prior art, the patient body position adjusting efficiency is low is solved, and the patient body position adjusting efficiency is improved.

The invention relates to the technical field of medical infrared image processing and intraoperative body temperature monitoring, and discloses an intraoperative patient body temperature distribution monitoring method and system based on an infrared image. The method comprises the steps of infrared thermal imaging image acquisition and temperature calibration preprocessing, human body exposed body surface area intelligent segmentation and interference heat source elimination, anatomical area temperature field characteristic parameter extraction and analysis and intraoperative low body temperature risk dynamic evaluation and early warning. The limitation of traditional single-point temperature measurement is overcome, and adaptive monitoring parameter adjustment is realized based on a closed-loop feedback mechanism.

The invention discloses a fat melting method and system for controlling laser intensity based on skin color, and a storage medium. The fat melting method comprises the following steps: constructing a three-dimensional surface model of a body surface area; acquiring skin color feature data of the region to be subjected to fat melting through a multi-mode sensor; the skin color feature data and the three-dimensional surface model are input into a pre-trained skin color grading model, the skin color grading model carries out skin color grade classification on the skin area according to the skin color feature data, and a skin color grading three-dimensional model at least comprising three skin color grades is obtained, the three skin color grades at least comprise a light skin color, a normal skin color and a deep skin color; generating a laser intensity control scheme according to the skin color grading three-dimensional model; and according to the laser intensity control scheme, grease melting laser is used for executing irradiation operation.