The invention discloses a novel drug-coated stent. The novel drug-coated stent comprises a stent body and a drug coating applied to the stent body, wherein the drug coating comprises drug and a drug carrier, the drug contains a tissue factor pathway inhibitor which is TFPI-1or TFPI-2, and the mass ratio of the drug to the drug carrier is 1:(8-12). The drug further contains one or two of sirolimus drug, taxol drug and statin drug. The thickness of the drug coating is 100-230 microns. The novel drug-coated stent has the advantages that stent thrombosis incidence can be reduced, the rate of recurrence of infarction and fatality rate of patients can be reduced remarkably, and long-term prognosis can be improved; usage of antiplatelet drugs and anticoagulant drugs is reduced, and the occurrence rate of bleeding events is reduced; the tissue factor pathway inhibitor is tissue factor physiological inhibitor, has high blood compatibility and histocompatibility, and is free of toxic or side effect and has few influences on human body.