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Oil-soluble pesticide nano capsules and preparation method thereof

A nanocapsule and oil-soluble technology, applied in botany equipment and methods, animal repellents, biocides, etc., can solve the problem of the reduction of drug efficacy, and achieve the effect of mild conditions and easy industrial production

Inactive Publication Date: 2009-06-24
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the polymerization method, the monomer will inevitably combine with the encapsulated pesticide during the polymerization process, resulting in a decrease in the efficacy of the drug.
At present, no pesticide nanocapsules have been prepared by coacervation under mild conditions.

Method used

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  • Oil-soluble pesticide nano capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Dissolve 0.5 g of methylamino abamectin in 8 g of ethyl acetate, add 4 g of alkylphenol polyoxyethylene ether and 6 g of sodium dodecylbenzene sulfonate to form a compound surfactant, 0.5 g as an adjuvant Ethylene glycol and 20g water are mixed and stirred to obtain an O / W type microemulsion. The microemulsion was kept at a constant temperature in a 35° C. water bath, and 10 g1% chitosan acetic acid aqueous solution and 8 g 10% gelatin aqueous solution were added, and the pH value of the solution was adjusted to 5.5 with 5% acetic acid solution. The solution is cooled to 6° C., a small amount of 5% glutaraldehyde solution is added for cross-linking and solidification, and raised to room temperature to obtain a nanocapsule suspension containing emamectin.

Embodiment 2

[0045] Dissolve 0.5g ivermectin in 5g toluene, add 4g alkylphenol polyoxyethylene ether and 6g sodium dodecylbenzene sulfonate as a compound surfactant, 0.5g butanol as an adjuvant, 20g Water, mixed and stirred to obtain O / W type microemulsion. The microemulsion was kept at a constant temperature in a water bath at 40°C, 8g of 10% gelatin aqueous solution and 8g of 10% gum arabic aqueous solution were added, and the pH value of the solution was adjusted to 4.0 with 5% acetic acid solution. The solution was cooled to 6° C., a small amount of 5% glutaraldehyde solution was added for cross-linking and solidification, and the solution was raised to room temperature to obtain a nanocapsule suspension containing ivermectin.

Embodiment 3

[0047] Dissolve 0.5g diflubenzuron in 8g xylene, add 6g castor oil polyoxyethylene ether and 5g sodium lauryl sulphate compound surfactant, 0.8g isopropanol as adjuvant, 30g water, After mixing and stirring, an O / W type microemulsion is obtained. The microemulsion was kept at a constant temperature in a water bath at 40° C., 5 g of 10% gelatin aqueous solution and 5 g of 10% gum arabic aqueous solution were added, and the pH of the solution was adjusted to 4.5 with 5% acetic acid solution. The solution is cooled to 6° C., a small amount of 5% glutaraldehyde solution is added for cross-linking and solidification, and the temperature is raised to room temperature to obtain a nanocapsule suspension containing diflubenzuron.

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Abstract

Disclosed is an oil soluble pesticide nm capsule and preparation method, having weight ration of: pesticide: 0.5-4%; high molecular compound: 8-25%; mixed-surfactant: 8-20%; cosurfactant 3-10%; crosslinking agent 0.5-1.0%; organic solvent 3-10%; water: added to 100%, wherein the high molecular compound is selected from sodium lignosulfonates, chitosan, gum arabic or glutin, one or two is / are selected for agglutination reaction, forming capsule skin of the nm capsule; the capsule core is pesticide bulk drug, selected from diflubenzuron, emamectin benzoate, abamectin, imidacloprid, ivermectin or highly active cypermethrin. The mixed-surfactant adopts nonionic surfactant and anionic surfactant for compound. The pesticide nm controlled release preparation prepared by the invention is easy in storage, high in stability, large in drug-loading rate and high in dispersion.

Description

Technical field [0001] The invention relates to the preparation of a novel pesticide nanocapsule, which uses natural polymers such as sodium lignosulfonate, chitosan, gum arabic and gelatin as polymer materials, and obtains the nanocapsules in a microemulsion by a coacervation method. The nanocapsules obtained by the invention are suitable for the encapsulation of oil-soluble pesticides. Background technique [0002] At present, the main formulation of oil-soluble pesticides is emulsifiable concentrate, which contains a lot of organic solvents, wastes resources and pollutes the environment, has poor dispersion and low effective utilization rate, resulting in a large amount of pesticide residues. Therefore, reducing toxicity and improving efficacy is the development trend of pesticides. The development of formulations to achieve the purpose of reducing toxicity and increasing efficacy is a more economical and faster way than the development of original drugs. Chinese patents CN 17...

Claims

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Application Information

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IPC IPC(8): A01N25/04A01N25/28
Inventor 朱银燕安学勤
Owner NANJING NORMAL UNIVERSITY
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