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Gene group for selection and/or prognostic evaluation of lung cancer treatment scheme, gene chip and detection kit thereof

A technology for detection kits and treatment plans, applied in the field of gene groups, can solve the problems of lack of molecular screening research work, and achieve the effects of avoiding statistical analysis, simple methods, and strong accuracy

Inactive Publication Date: 2010-03-17
BEIJING YILING BIOENGINEERING & TECH CO LTD
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AI Technical Summary

Problems solved by technology

However, in the field of lung cancer, especially for the Chinese population, research work on molecular screening is still lacking

Method used

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  • Gene group for selection and/or prognostic evaluation of lung cancer treatment scheme, gene chip and detection kit thereof
  • Gene group for selection and/or prognostic evaluation of lung cancer treatment scheme, gene chip and detection kit thereof
  • Gene group for selection and/or prognostic evaluation of lung cancer treatment scheme, gene chip and detection kit thereof

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Experimental program
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Embodiment 1

[0039] 1. Organizational collection, storage and recording

[0040] The tissues to be tested collected in this example were all fresh tissues (including normal tissues, near-tumor tissues and tumor tissues) that were sampled rapidly after surgical resection of lung cancer. The tissue to be tested was quickly stored in a -80°C refrigerator and taken out before use. Record relevant clinical and pathological information, including: time of diagnosis, type of surgery, type of non-surgical treatment (preoperative or postoperative), pathological diagnosis results (including tumor type, lymph node metastasis, degree of spread to surrounding tissues, and tumor stage) ). The following information was recorded during the subsequent clinical treatment: health status, recurrence rate and mortality. The median observation period of group 1 (screening group) was 19 months (12-25IQR), and the median observation period of group 2 (verification group) was 49 months (5.8-62.5IQR).

[0041] 2...

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Abstract

The invention relates to a gene group which relates to twelve genes, and the detection for the change of the expression situation of two or more genes in the gene group can be used for the selection and / or the prognostic evaluation of a lung cancer treatment scheme. The gene group can be used for preparing a gene chip and a detection kit. Through the identification for a plurality of gene expression ways, the method is simple and convenient, strong in accuracy, lower in cost and easy to accept by the general patients. The invention has important guide significance for the selection (such as chemotherapy or radiotherapy) of a clinical treatment scheme. Simultaneously, the invention also can effectively predict the treating effect of the treatment scheme and besides, the invention further can find out a new target point in the treatment of lung cancer.

Description

technical field [0001] The invention relates to a gene group, the detection of the expression of the gene group can be used for the selection of the lung cancer treatment plan and / or the prognosis assessment, and the gene group can be used for preparing a gene chip and a detection kit. Background technique [0002] Lung cancer is the most common cancer in China and worldwide. There are more than 1.3 million new cases worldwide each year. By the end of the 20th century, it has become one of the most important causes of death in the world, and it is the main cause of cancer death. From the perspective of the age of lung cancer patients, cases under the age of 40 are rare, and the incidence of lung cancer increases sharply after the age of 40, with the peak incidence occurring between the ages of 75 and 84. Smoking has been recognized as the main cause of lung cancer, accounting for about 85% to 90% of all lung cancers. Compared with non-smokers, the probability of lung cance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C40B40/06C12N15/11
Inventor 张力建姜文国
Owner BEIJING YILING BIOENGINEERING & TECH CO LTD
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