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Detection kit for detecting MDS/MPN (myelodysplastic syndrome/myeloproliferative neoplasms) related gene group

A detection kit and the technology of the kit, which are applied in the field of molecular biology, can solve the problems of low accuracy of diagnostic methods, lack of diagnostic methods for MDS/MPN, and limitations of diagnostic methods for MDS/MPN, and achieve high detection efficiency and high detection rate. Effect

Inactive Publication Date: 2018-04-03
天津见康华美医学诊断技术有限公司
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Problems solved by technology

[0005] The present invention aims at the technical defects of the prior art, and provides a detection kit for detecting MDS / MPN-related gene groups, so as to solve the limitations of the diagnostic methods of MDS / MPN in the prior art and the lack of diagnosis of MDS from the perspective of molecular biology. / MPN based technical issues
[0006] Another technical problem to be solved by the present invention is that the diagnostic method accuracy of MDS / MPN in the prior art is relatively low

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  • Detection kit for detecting MDS/MPN (myelodysplastic syndrome/myeloproliferative neoplasms) related gene group
  • Detection kit for detecting MDS/MPN (myelodysplastic syndrome/myeloproliferative neoplasms) related gene group
  • Detection kit for detecting MDS/MPN (myelodysplastic syndrome/myeloproliferative neoplasms) related gene group

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[0035] Specific embodiments of the present invention will be described in detail below. In order to avoid unnecessary details, well-known structures or functions will not be described in detail in the following embodiments. Unless defined otherwise, technical and scientific terms used in the following examples have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0036] Materials and methods:

[0037] Among the patients diagnosed in the Hematology Hospital of the Chinese Academy of Medical Sciences and the Xihe Huamei Medical Diagnosis Center from August 2015 to March 2017, we conducted continuous enrollment (44 patients) according to the following criteria.

[0038] Inclusion criteria were: patients with myelodysplastic syndrome / myeloproliferative neoplasm (MDS / MPN) diagnosed by cytomorphology and flow cytometry.

[0039] The diagnostic results of the 44 patients are shown in Table 4:

[0040] Table 4 List of pa...

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Abstract

The invention relates to a detection kit for detecting an MDS / MPN (myelodysplastic syndrome / myeloproliferative neoplasms) related gene group. According to the technical scheme, firstly, a gene group used for screening MDS / MPN related gene mutation is determined, and 17 genes with high directivity are screened out. On the basis, a high-throughput sequencing technology is combined, auxiliary diagnosis of the MDS / MPN beyond the morphology and the flow cytometry can be realized, and particularly, the detection kit has special advantages in evaluation of disease prognosis and anticipation of actioneffects on related target medicines. The provided detection kit of the gene group for used for screening MDS / MPN related gene mutation has the advantages of high detection efficiency, high detectionrate and the like.

Description

technical field [0001] The invention relates to the technical field of molecular biology, further relates to a detection kit for screening MDS / MPN-related gene mutations and a medical interpretation database thereof, in particular to a detection kit for detecting MDS / MPN-related gene groups. Background technique [0002] Myelodysplastic syndromes / myeloproliferative neoplasms (MDS / MPN) are a group of clinical, laboratory and morphological features that overlap or compound both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs). Myeloid tumors. The clinical and hematological features of MDS / MPN have the dual characteristics of MDS and MPN, that is, one or more lineages of myeloid cells have ineffective hematopoiesis and pathological hematopoiesis in MDS, and a corresponding series of cytopenias appear in peripheral blood, and another line or multiple lineages. Myeloid cells showed efficient proliferation of MPN, resulting in an increase in the correspondi...

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/156C12Q2600/16
Inventor 汝昆蔺亚妮其他发明人请求不公开姓名
Owner 天津见康华美医学诊断技术有限公司
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