45 results about "Myeloproliferative neoplasm" patented technology

Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including, but not limited to, malignant melanomas, solid tumors, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, hepatic cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, chronic myelogenous leukemia, leukemias, papillary thyroid carcinoma, non-small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, diabetic retinopathy, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocytosis, mast cell leukemia, and diseases caused by PDGFR-α kinase, PDGFR-β kinase, c-KIT kinase, cFMS kinase, c-MET kinase, and oncogenic forms, aberrant fusion proteins and polymorphs of any of the foregoing kinases.

The present invention relates to a deuterated phenylamino pyrimidine compound and a drug composition containing the deuterated phenylamino pyrimidine compound. Particularly the present invention discloses a deuterated phenylamino pyrimidine compound represented by a formula (I), and a drug composition containing the deuterated phenylamino pyrimidine compound, or a crystal form, a pharmaceutically acceptable salt, a hydrate or a solvate thereof. The compound can be used for treating and / or preventing JAK kinase-associated diseases such as myeloproliferative diseases, cancers, immunologic diseases and the like.

Methods of treating, preventing and / or managing a myeloproliferative disease are disclosed. Specific methods encompass the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent, and / or the transplantation of blood or cells. Particular second active agents are capable of suppressing the overproduction of hematopoietic stem cells or ameliorating one or more of the symptoms of a myeloproliferative disease. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

The present invention relates to substituted fused tricyclic compounds of formula (I) or (Ia), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by JAK activity. The compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders mediated by JAK activity. Such conditions include, but not limited to, arthritis, Alzheimer's disease, autoimmune thyroid disorders, cancer, diabetes, leukemia, T-cell prolymphocytic leukemia, lymphoma, myleoproliferation disorders, lupus, multiple myeloma, multiple sclerosis, osteoarthritis, sepsis, psoriatic arthritis, prostate cancer, T-cell autoimmune disease, inflammatory diseases, chronic and acute allograft transplant rejection, bone marrow transplant, stroke, asthma, chronic obstructive pulmonary disease, allergy, bronchitis, viral diseases, or Type I diabetes, complications from diabetes, rheumatoid arthritis, asthma, Crohn's disease, dry eye, uveitis, inflammatory bowel disease, organ transplant rejection, psoriasis and ulcerative colitis. The present disclosure also relates to process for the preparation of such compounds, and to pharmaceutical compositions containing them.

The invention provides methods for determining the prognosis of a patient diagnosed with a leukemia, including B-cell chronic lymphocytic leukemia, by measuring mutations of the WT1 gene in a biological sample. The invention also relates to the diagnosis of leukemia, including B-cell chronic lymphocytic leukemia.

In part, the present disclosure relates methods for treating, preventing, or reducing the severity of a myeloproliferative disorder (e.g., polycythemia vera, essential thrombocythemia, and myelofibrosis) or one or more complications of a myeloproliferative disorder. The present disclosure further relates methods for treating, preventing, or reducing the severity of a Janus kinase-associated disorder or one or more complications of a Janus kinase-associated disorder. In certain aspects the disclosure provides TβRII antagonists for treating, preventing, or reducing the severity of a myeloproliferative disorder (e.g., polycythemia vera, essential thrombocythemia, and myelofibrosis) or a Janus kinase-associated disorder or one or more complications of a myeloproliferative disorder or a Janus kinase-associated disorder.

The present invention discloses method of detecting JAK2V617F mutation and its special primer and TaqMan-MGB probe. The primer for detecting the genome DNA JAK2V617F mutation of myeloproliferative diseases is the primer pair shown in the SEQ ID No. 1 and SEQ ID No. 2 in the sequence list. The primer for detecting cDNA JAK2V617F mutation of myeloproliferative diseases is the primer pair shown in the SEQ ID No. 3 and SEQ ID No. 4 in the sequence list. The TaqMan-MGB probe has the DNA sequence shown in the SEQ ID No. 5 and SEQ ID No. 6 in the sequence list; and the DNA sequence has reporter fluorophore of different colors in the 5' end, and quenching group marked in the 3' end and connected dihydro clyclic indol porphyrin-tripeptide. The present invention provides one fast, reliable and accurate way for the diagnosis of MPDs, and can further provide the determined ratio between JAK2 mutation gene and wild JAK2 gene, so as to provide basis for treating observation.

Provided herein are methods for reducing neoplastic progenitor cell proliferation and alleviating symptoms associated in individuals diagnosed with or thought to have Essential Thrombocythemia (ET). Also provided herein are methods for using telomerase inhibitors for maintaining blood platelet counts at relatively normal ranges in the blood of individuals diagnosed with or suspected of having ET.

The invention relates to a kit for quantitatively detecting the W515 site mutation of MPL genes, belonging to the field of biotechnology. The kit comprises at least one system of the W515L site mutation specific system of the MPL genes and the W515K site mutation specific system of the MPL genes, and an inner reference gene ABL system, wherein each system comprises an upstream primer, a downstream primer and a Taqman fluorescent probe. Research shows that the gain-of-function mutation rates of the W515L site mutation of the MPL genes and the W515K site mutation of the MPL genes are 10% and 3% in PMF and ET respectively, and are not found in PV. Therefore, the W515L site mutation of the MPL genes and the W515K site mutation of the MPL genes are mainly used for diagnosing the PMF and the ET. With the adoption of the fluorescent quantitative PCR (polymerase chain reaction) which is high in sensitivity and specificity for detecting the W515L site mutation of the MPL genes and the W515K site mutation of the MPL genes, the specificity and the sensitivity of the detection result are remarkably improved. Via the kit disclosed by the invention, a novel rapid, simple and convenient gene diagnosis technology is provided for prediction for myeloproliferative diseases.

The present invention relates to a deuterated phenyl amino pyrimidine compound and pharmaceutical composition containing the same. Specifically provided are a deuterated phenyl amino pyrimidine compound as represented by formula (I), and pharmaceutical composition containing the compound, or polymorph, pharmaceutically acceptable salt, hydrate or solvate thereof. The compound of the present invention can treat and / or prevent JAK kinase-related diseases, such as bone marrow proliferative disease, cancer, immunologic diseases and the like.

The invention discloses the application of PEDF in the preparation of drugs for the treatment of myeloproliferative diseases. The research of the invention finds that PEDF can promote the proliferation of normal hematopoietic stem cells in MPN mice, inhibit the proliferation of tumor cells, reduce peripheral blood images, and reduce mortality. PEDF It can be used as a potential drug for the treatment of myeloproliferative diseases.

Compositions and fragment length analysis methods are provided for detecting CALR mutations and determining tumor load in patients with myeloproliferative neoplasms.