33 results about "Chronic phase chronic myelogenous leukemia" patented technology

The present invention provides antigen binding proteins that specifically bind to Wilms' tumor protein (WT1), including humanized, chimeric and fully human antibodies against WT1, antibody fragments, chimeric antigen receptors (CARs), fusion proteins, and conjugates thereof. The antigen binding proteins and antibodies bind to HLA-A0201-restricted WT1 peptide. Such antibodies, fragments, fusion proteins and conjugates thereof are useful for the treatment of WT1 associated cancers, including for example, breast cancer, ovarian cancer, prostate cancer, chronic myelocytic leukemia, multiple myeloma, acute lymphoblastic leukemia (ALL), acute myeloid / myelogenous leukemia (AML) and myelodysplastic syndrome (MDS). In more particular embodiments, the anti-WT1 / A antibodies may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and / or expression levels.

The invention is a new organic chemical synthesis method, especially the key intermediate N-(2-methyl-5-nitrate) of the tyrosine protein kinase inhibitor imatinib for the treatment of diseases such as chronic myelogenous leukemia base) phenyl-4-(3-pyridyl) pyrimidin-2-amine and the preparation method of N-phenyl-pyrimidin-2-amine derivatives similar to its structure, the target product can be obtained by 4-aromatic heterocyclic group- 2-halogenated pyrimidine and substituted aniline are obtained by condensation in the presence of a catalyst. The preparation method has low raw material price, scientific and reasonable synthesis route, high product yield, practical value, great social and economic benefits, and can be used for the prevention and treatment of diseases caused by protein tyrosine kinases. treat.

The invention relates to a thiazoleamide compound and medical application thereof in treating malignant tumor. The thiazoleamide compound is an ideal Bcr-Abl and Src protein tyrosine kinase inhibitor and shows favorable effects when used for treating the malignant tumors, such as chronic myeloid leukemia, acute myeloid leukemia, acute lymphocytic leukemia, myelodysplastic syndromes, lung cancers, ovarian cancers, prostatic cancers, soft tissue sarcomas, malignant gliomas, and the like, and meanwhile, the thiazoleamide compound has the advantages of less usage amount and side effect.

Indirubin is the major active anti-tumor component of a traditional Chinese herbal medicine used for treatment of chronic myelogenous leukemia (CML). One aspect of the invention relates to a method of treating CML using at least one indirubin derivative compound or a pharmaceutical composition thereof. Indirubin derivatives (IRDs) potently inhibited Signal Transducer and Activator of Transcription 5 (Stat5) protein in CML cells. Compound IRD 810 inhibits Bcr-Abl / Stat5 or Src / Stat5 signaling in human KCL-22 CML and imatinib-resistant human KCL-22 CML cells expressing the T315I mutant Bcr-Abl. Previous studies indicate that SFKs cooperate with Bcr-Abl to activate downstream Stat5 signaling. Activation of Stat5 was strongly blocked by IRD 810 in CML cells. IRDs disclosed herein have been identified as potent inhibitors of Bcr-Abl / Stat5 or SFK / Stat5 signaling pathway. IRDs disclosed herein are new therapeutics for wild type or T315I mutant Bcr-Abl-positive CML patients, and may also treat other solid tumors, including prostate cancer and lymphoma.

One embodiment of the present invention provides a detection kit for detecting a chronic myelogenous leukemia (CML) gene expression, wherein the detection kit includes a primer set which is specifically bound to the CML gene; and a cleavable probe which is specifically bound to the inside of a CML gene amplification product which is amplified by the primer set. Another embodiment of the present invention provides a method of measuring the CML gene expression by using the detection kit according to one embodiment of the present invention. The method according to one embodiment of the present invention is used to efficiently detect a low CML gene expression for CML diagnosis and prognosis diagnosis.