The invention discloses a drug for preventing and curing shiver after intraspinal anesthesia and a preparation method thereof. The drug is prepared from the following medicinal materials: Chinese pyrola herb, medicinal indianmulberry roots, sea otter, Crepis rigescens Diels, Habenria petelotii Gagnep., cynomorium songaricum, donkey kidney, Curculigo capitulata root, clove, securinega suffruticosa, radix linderae, Gordon euryale seed, lily, selenitum, Tupistra pachynema Wang et Tang, Valeriana jatamansi, rhizoma zingiberis, radix angelicae, Tiarella polyphylla, folia perillae acutae, Houttuynia cordata, japanese violet herb or root, liquorice, garden burnet, astragalus, acanthopanax, divaricate saposhnikovia root, Themeda triandra fruit and ephedra herb root. The drug has the beneficial effects of being capable of preventing and curing shiver after intraspinal anesthesia and well relieving shiver symptoms fundamentally, treating both symptoms and root causes, eliminating and relieving the shiver phenomenon after intraspinal anesthesia, and being free of toxic and side effects and remarkable in effect.