The invention relates to medicinal liquor for treating bone disease, being a medicament prepared from the following materials in parts by weight: 50 parts of henry rhodiola herb, 50 parts of rhizoma panacis japonici, 50 parts of root of tall monkshood, 50 parts of tsingling bergenia rhizome, 15 parts of arisaema fargesii, 15 parts of rodgersia aesculifolia batal, 18 parts of wild chervil, 30 parts of asarum caulescens, 50 parts of twisted-stalk, 20 parts of herb of laciniate begonia, 50 parts of polygonum suffultum, 12 parts of largeflower wildginger herb, 30 parts of cynura pinnatifida, 24 parts of tabasheer, 24 parts of dysosma versipellis, 30 parts of radix gaulophylli, 15 parts of airpotato yam, 24 parts of henry clematis root, 30 parts of achyranthes root, 30 parts of pawpaw, 30 parts of club moss, 30 parts of cassia twig, 50 parts of fiveleaf akebia, 24 parts of erythrina bark, 18 parts of tschonosk trillium rhizome and 24 parts of wild buckwheat rhizome. The invention also relates to the preparation method of the medicinal liquor. The medicinal liquor provided by the invention can be used for treating rheumatic numbness of limbs, rheumatic arthritis, cervical spondylosis, periarthritis humeroscapularis, ischialgia caused by lumbar muscle strain, hyperosteogeny, hernia of intervertebral disc, spondylosis and ischemic necrosis of femoral head, traumatic injury, bone fracture, soft tissue contusion sequelae and the like.