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Method for extracting effective active component of rodgersia aesculifolia and use thereof

A technology of active ingredients and extraction methods, which is applied in the field of preparation of antiviral and antibacterial and bactericidal drugs, can solve the problems of lack of antiviral means, and achieve a wide range of antibacterial and sterilizing, no toxic and side effects, and significant curative effect Effect

Inactive Publication Date: 2003-08-06
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the virus can persist in the myocardium after infection, there is still a lack of effective antiviral means[1]

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 200g of the root tuber of Suogudan, select it, slice it, wash it, dry it, and crush it to a particle size of 10 meshes; use 1000g of medical ethanol with a concentration of 45% to 60% for total extraction, and the extraction method is cold soaking. The time is 7 days each time, the number of extractions is 4 times, and the extraction temperature is 25°C. Then the polar part is extracted with an organic solution, the organic solution can be chloroform, ethyl acetate, n-butanol; then conduct an activity test, cooperate with pharmacological screening, and discard the residue; after the solvent is recovered under reduced pressure, the extract is concentrated into an extract; Parts are chromatographically separated with a chromatographic column, column chromatography uses silica gel as a filler, and uses chloroform: ethyl acetate: formic acid = 12:5:0.1 as an eluent to obtain the eluent of the active part, that is, the effective active ingredient .

Embodiment 2

[0023] Take 150g of the root tuber of Suogudan, select it, slice it, wash it, dry it, and crush it to a particle size of 3-5mm; use 750g of medical ethanol with a concentration of 70-75% for total extraction, and the extraction method is hot flow method, the reverse flow time is 3 hours each time; the reverse flow frequency is 3 times. Then the polar part is extracted with an organic solution, the organic solution can be chloroform, ethyl acetate, n-butanol; then conduct an activity test, cooperate with pharmacological screening, and discard the residue; after the solvent is recovered under reduced pressure, the extract is concentrated into an extract; Use chromatographic column for chromatographic separation of parts, column chromatography uses polyamide as filler, and n-butanol: chloroform: formic acid = 8:3:1 as eluent to obtain the eluent of the active part, that is, the effective activity Element.

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Abstract

The present invention relates to a method for extracting effective active component of Chinese medicinal material rodgersia aesculifolia and its application in preparation of medicine for resisting virus and inhibiting and killing bacteria. Its preparation method includes the following steps: a. using root tuber of the rodgersia aesculifolia as raw material, slicing, cleaning, drying and pulverizing; b. using organic solution whose concentration is 45-95% to make extraction, separating polar region, using organic solution to make extraction, making activity test, screening and removing residue, its extraction mode can be cold-impregnation or thermal reverse-flow; c. reducing pressure and recovering solvent, extracting, concentrating to obtain the extractum.

Description

(1) Technical field: [0001] The invention relates to a method for extracting effective and active components of Suogudan and the application of the effective and active components of Suogudan in the preparation of antiviral and antibacterial and sterilizing drugs. (two) background technology: [0002] At present, some western medicines and Chinese patent medicines have been used as antiviral drugs at home and abroad. The former has certain side effects after being taken by patients, while the latter has no obvious curative effect on patients. [0003] According to the World Health Organization Global Virus Surveillance Research Report, Coxsackie virus is the most common infection in the population. Among the cases of sudden death in newborns and children, 20% are caused by viral myocarditis. Since the virus can persist in the myocardium after infection, there is still a lack of effective antiviral means [1]. [0004] [1] "Health News", March 20, 2001, Jiang Ming. [0005]...

Claims

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Application Information

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IPC IPC(8): A61P31/04A61P31/12
Inventor 郑尚珍
Owner NORTHWEST NORMAL UNIVERSITY
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