33 results about "Organophosphorus Poisoning" patented technology

The present invention is in the field of drug delivery, and specifically, cationic liposome-based drug delivery. In embodiments, this invention provides methods of making ligand-targeted (e.g., antibody- or antibody fragment-targeted) liposomes useful for the delivery of liposomes to tumors, including brain tumors. In embodiments, the liposomes deliver temozolomide across the blood-brain barrier for treatment of primary or metastatic brain tumors. Additional cancers that can be treated with the liposomes include neuroendocrine tumors, melanoma, prostate, head and neck, ovarian, lung, liver, kidney, breast, urogenital, gastric, colorectal, cervical, vaginal, angiosarcoma, liposarcoma, rhabdomyosarcoma, choriocarcinoma, pancreatic, retinoblastoma and other types of cancer. In another embodiment the liposomes deliver melphalan for the treatment of multiple myeloma, other tumors of the blood or other solid tumors. In still other embodiments the liposomes can deliver other drugs such as pemetrexed or irinotecan for treatment of cancer or drugs including atropine for treatment of organophosphate poisoning.

A pharmaceutical composition comprising (i) a carbamate; (ii) a first anticholinergic; (iii) a second anticholinergic; and (iv) a pyridinium salt. The pharmaceutical composition is suitable for the treatment of organophosphate poisoning, including nerve agent and pesticide poisoning. The pharmaceutical composition provides an effective therapy against the lethal effects of nerve agent, provides effective protection from the effects of incapacitation and does not require the use of a pre-treatment. A kit comprising the pharmaceutical composition is also described and claimed.

A super engineered bacterium able to degradate the residual agricultural chemical contains the gene to code detoxicating lipase and hydrolase, so it can induce the expression of detoxicating lipase and hydrolase. Its configuring process includes cloning the genes of detoxicating lipase and hydrolase, respectively cloning them to expression carrier pETDuet-1, configuring fusion expression carrier pETDuet-b1-opd, transferring to obtain recombinant strain, and inductive culture. It can be used to eliminate residual agricultural chemical.

Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a reaction called aging, leading to an aged-AChE adduct. The invention provides compounds and methods that can be used to reactivate an aged-AChE adduct. Such compounds and methods are useful to counteract organophosphorus poisoning.

The present invention provides new compositions and methods for treating and / or reversing organophosphate intoxication, manifested by both cholinergic and non-cholinergic crisis, in a mammal resulting from exposure to organophosphate compounds. The neurosteroidal compounds of this invention are those having the general structural formula of pregnane, androstane, 19-norandrostanes, and norpregnane with further moieties as defined herein. These compounds include, but are not limited to, ganaxolone, pregnanolone, and androstanediol and their analogs, salts and prodrugs. The present invention further relates to combining a therapeutically effective amount of a neurosteroidal compound with a standard organophosphate antidote (e.g. atropine, pralidoxime). The data suggests that neurosteroids are effective or more effective than benzodiazepines, whether given earlier or later than 40-min (up to several hours) after organophosphate compound exposure. Neurosteroids are effective to attenuate long-term neuropsychiatric deficits caused by organophosphate exposure.

The present invention relates treatments of a toxin in a subject. The toxin at least partially effects its toxicity in the subject via binding to a target cell of the subject. The present invention provides for methods, combinations and pharmaceutical compositions for decreasing or neutralizing the effect of a toxin in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, and an outer surface comprising a cellular membrane derived from a source cell. Exemplary toxins include acetylcholinesterase (AChE) inhibitors such as organophosphate poisoning.

Human serum paraoxonase enzyme and DNA (RNA) encoding such serum paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of such polypeptides include their use as an antidote for organophosphate poisoning and to prevent neuronal cell death.

A super engineered bacterium able to degradate the residual agricultural chemical contains the gene to code detoxicating lipase and hydrolase, so it can induce the expression of detoxicating lipase and hydrolase. Its configuring process includes cloning the genes of detoxicating lipase and hydrolase, respectively cloning them to expression carrier pETDuet-1, configuring fusion expression carrier pETDuet-b1-opd, transferring to obtain recombinant strain, and inductive culture. It can be used to eliminate residual agricultural chemical.

The invention provides application of astaxanthin and / or lithium chloride in preparation of drugs for preventing and treating cognitive disorder diseases caused by chronic organophosphorus poisoning. Astaxanthin and lithium chloride inhibitors are used in a combined manner, the treatment effect of a group which uses the astaxanthin and lithium chloride inhibitors in the combined manner is more obvious than the treatment effect of a group which independently uses astaxanthin, and phosphorylation level of protein of Akt / GSK3 beta / CREB signal channels in brains of mice is remarkably higher than that of a model group. Therefore, a treating mode of using the astaxanthin and the lithium chloride in a combined manner has remarkable neuroprotective effect of resisting oxidation and inhibiting apoptosis, and the cognitive function of OPS poisoned mice is improved. The treating mode of using the astaxanthin and the lithium chloride in the combined manner has the neuroprotective effect on hippocampus injury caused by chronic organophosphorus poisoning, cognitive function disorder caused by chronic organophosphorus poisoning is improved by activating the Akt / GSK3 beta / CREB signal channels, and therefore, the treating reagent is expected to be developed into novel drugs for preventing and treating cognitive disorder caused by chronic organophosphorus poisoning.

The present invention is directed to various methods for treating organophosphorus poisoning in an animal that is at risk of exposure to an organophosphorus compound or preventing organophosphorus poisoning in an animal that has been exposed to an organophosphorus compound, by administering a therapeutically effective amount of galantamine or a salt thereof, or a biologically active analog, derivative, fragment or variant thereof.

The invention relates to methods of treating or preventing organophosphate poisoning in a subject in need thereof, comprising administering to the subject isoflurane, enflurane, halothane, sevoflurane, desflurane, xenon or argon in a therapeutically effective amount.

Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) or butyrylcholinesterase (BuchE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds.

An organophosphate scavenger is provided, with extended residence time in the mammalian circulation, which can be used in preventive and therapeutic treatment of organophosphate poisoning. The scavenger is a uniformly pegylated serine hydrolase, in which a part of lysine residues were replaced with other residues by site-directed mutagenesis. One part of lysine residues in the hydrolase amino acid sequence is selected for the PEG-coupling, and the other part for the replacement, wherein the selection should ensure that the hydrolase surface shows at least one free amino acid for PEG coupling for all possible views obtained by rotating a 3-D model generated for the hydrolase.

The present invention relates to compositions comprising an antiemetic, particularly including 5-HT3 antagonist and / or NK-1 antagonist antiemetics, in combination with a choline esterase inhibitor such as an acetylcholine esterase inhibitor and / or a butyrylcholine esterase inhibitor, and methods of using the composition to provide improved protection of subjects at risk of organophosphorus poisoning, or, for the treatment, prevention, or alleviation / reduction of toxicity from an organophosphorus compound, by enabling the use of a highly protective daily dose of the choline esterase inhibitor without the typical adverse effects.

A method of treating organophosphorous (OP) poisoning comprising administering to a mammal at risk for OP poisoning an OP poisoning-inhibiting amount of galantamine.

The invetnio discloses hyper-engineering bacteria to decompose residual pesticide with reserving number at CGMCC No.1529, which is characterized by the following: cloning the gene of P450 CYP9G2 and P450 reductase on the pETDuet-1; constructing pETDuet-CYP-POR; transmitting into escherichia coli; sieving to obtain the product. The invention also provides detoxication enzyme, which is fit for detoxicating organophosphorus intoxication animal.