15 results about "Halothane" patented technology

The invention relates to the technical field of medical equipment, in particular to a self-adaptive Alzheimer's disease anesthetic gas flow limiting device which is applied to the biomedical engineering industry and comprises a machine body, a display screen, a multi-parameter detector, a detection probe, a gas output device, a gas output pipe, a reversing valve and a corrugated pipe. The reversing valve comprises a reversing valve body and further comprises a flow descending mechanism, a reversing mechanism, a linkage mechanism, a driving mechanism and a limiting mechanism, the flow descending mechanism is arranged in the reversing valve body, the reversing mechanism is installed in the reversing valve body and connected with the flow descending mechanism, the linkage mechanism is connected with the reversing mechanism, and the driving mechanism is connected with the linkage mechanism. The limiting mechanism is connected with the driving mechanism, when anesthetic gas flows through the flow lowering mechanism in the reversing valve, the driving mechanism is pressed to drive the linkage mechanism to rotate, the linkage mechanism drives the reversing mechanism to rotate synchronously, and the reversing mechanism swings to change the flow direction of the anesthetic gas in the flow lowering mechanism. The output concentration of sevoflurane is adjusted according to the volatilization conditions of sevoflurane at different temperatures, and the situation that under the condition that volatilization of sevoflurane is intensified at high temperature, the output gas concentration is too high, and consequently a patient suffering from the Alzheimer's disease inhales excessive sevoflurane, irreversible damage is caused to brain nerves of the patient is avoided.

The present invention relates to a method for the preparation of an N-monofluoroalkyl tropane, a method for the preparation of a trialkyltin tropane, a method for the preparation of an iodinated and / or radioiodinated tropane and the use of the N-monofluoroalkyl tropane as a precursor in the method for the preparation of the trialkyltin tropane and / or the iodinated and / or radioiodinated tropane.

The methoxyflurane charging device comprises a device body, a clamping cover is assembled and connected to one end of the device body, and the clamping cover comprises a cover plate used for being assembled and connected with the end of the device body and a medicine bin arranged on one side of the cover plate; an assembling groove correspondingly matched with the medicine bin is formed in the end of the device body in an embedded mode, a semicircular pad is arranged on one side of the inner wall of the medicine bin in an attached mode, a limiting assembly is installed on the side, opposite to the semicircular pad, of the cover plate, and an inserting hole is formed in the portion, between the semicircular pad and the limiting assembly, of the cover plate in a penetrating mode. A clamping type bottle is assembled in the inserting hole, a through hole communicated with the interior of the device body is formed in the bottom of the assembling groove in a penetrating mode, a driving assembly is embedded in the device body, and the output end of the driving assembly is located in the through hole. The whole replacing and assembling process can be operated through a single hand, and meanwhile the stability of the cartridge bottle can be improved through cooperation of the semicircular pad and the limiting assembly.

The application belongs to the technical field of medicine synthesis, and provides a new preparation method of isoflurane. The method uses hypochlorite and a strong acid as a chlorinating reagent to perform chlorination, which avoids the problems of low conversion rate and excessive chlorination to generate more impurities caused by chlorine gas chlorination. The reaction is more moderate, economical, environment-friendly and high-yield, and is suitable for industrial production.

To provide a pharmaceutical aerosol formulation for use in a pressurized metered dose inhaler (abbreviated as pMDI or MDI), particularly an improved pharmaceutical aerosol formulation for aerosol administration.SOLUTION: The present invention provides a pharmaceutical aerosol suspension formulation for MDI administration, comprising: (a) an atomization β2-stimulant, (b) micronized corticosteroid, (c) a quasi-therapeutic amount of a moisture scavenging excipient, and (d) an HFA propellant. The (a), (b) and (c) and their respective relevant amounts are selected such that they associate to form fluorocarbon having substantially the same density as that of the HFA (hydrofluoroalkane) propellant.SELECTED DRAWING: None

The application provides a preparation method and a packaging method of isoflurane, and belongs to the technical field of halogen-containing acyclic compounds. Trifluoroethanol and difluoro-chloromethane are used as starting materials, a selective fluorine reagent and NaCl solid are added, and the trifluoroethanol and the difluoro-chloromethane are etherified. Under the action of the selective fluorine reagent, the obtained etherification intermediate is chlorinated with NaCl, the reaction temperature of etherification and chlorination is 60-120 DEG C, and one-pot isoflurane preparation without intermediate taking is carried out. The preparation method has simple steps, simple subsequent treatment, and can obtain a product with high purity.

The application belongs to the technical field of medicine, and discloses application of oxeladin in preparation of a medicine for preventing or treating perioperative hypothermia. The dose of the medicine ranges from 1 to 3 mg. The medicine is applied to perioperative hypothermia caused by general anesthesia. The general anesthesia includes sevoflurane and esketamine. The medicine further comprises a pharmaceutically acceptable carrier and / or excipient. It is found in the previous application that the incidence of hypothermia and chills after general anesthesia is significantly reduced in the oxeladin administration group compared with the blank control group, and the further verification is carried out through animal experiments. The achievement of the application provides an effective prevention and treatment scheme for improving perioperative hypothermia and chills in clinic.

The invention discloses a recovery method of sevoflurane water-alcohol mother liquor, and belongs to the technical field of medicines. The method comprises the following steps: adding perlite into sevoflurane water-alcohol mother liquor, removing fluorine ions to obtain a fluoride-free water-alcohol solution, carrying out reduced pressure distillation on the solution to remove water, adding an inert organic solvent, recovering solid which is high-purity metal chloride, carrying out reduced pressure recovery on liquid which is the organic solvent, and recovering the residual solvent which is a high-boiling-point alcohol solvent; the sevoflurane water-alcohol mother liquor is a water phase obtained by adding water into a reaction solution of chloromethyl ether and alkali metal fluoride in a high-boiling-point alcohol solvent and carrying out phase splitting. Particularly, a reaction product metal chloride and high-boiling-point alcohol in the reaction are recycled. The benefit maximization of the sevoflurane process is realized, the three wastes are reasonably treated, and the comprehensive utilization of resources is realized.

An online detector for halothane anesthetics in blood uses ion mobility spectrometry as the basic detection technology and combines it with headspace sampling technology to achieve direct analysis of halothane anesthetic concentrations in whole blood without sample pretreatment. The detector consists of a fully automatic headspace sampler, a three-way connector, a variable-diameter sampling sleeve, and a negative ion mode photoionization ion mobility spectrometer. The fully automatic headspace sampler includes a sample carrier, a heating furnace, an injection needle and control components, a six-way valve quantitative loop, and a sample gas transmission tube; the three-way connector is connected to the sample gas transmission tube, the variable-diameter sampling sleeve, and the air purification tube and air respectively. The detection limit of sevoflurane tested by this device and method can reach a concentration below 1 ng / μl, and the detection and analysis time for a single sample is less than 2 minutes. The method of the present invention is intelligent, fast, efficient, and reliable.

The present disclosure relates to methods and compositions comprising cannabidiol (CBD) and a volatile anaesthetic, particularly isoflurane, useful for treating or preventing traumatic brain injury (TBI).

The application provides a preparation method of improved heptafluoroethane, which comprises the following steps: reacting hexafluoroisopropanol with bromochloromethane substituted with different halogen atoms under alkaline conditions to obtain an intermediate chloromethyl-2, 2, 2-trifluoro-1-(trifluoromethyl) ethyl ether, and then fluorinating the intermediate chloromethyl-2, 2, 2-trifluoro-1-(trifluoromethyl) ethyl ether by using a fluorinating agent to obtain heptafluoroethane. The method not only solves the technical defect that hydrogen fluoride or strong acid needs to be used in the heptafluoroethane production process in the prior art, which is not conducive to large-scale production, but also can avoid the generation of by-reaction impurities, obtain heptafluoroethane with high yield and high purity, avoid material waste, and improve the raw material utilization rate. The method has the advantages of easy raw material acquisition, low cost, mild reaction condition, convenient operation, high safety, and suitability for industrial application.

This invention discloses an anesthesia device for experimental pigs, belonging to the field of experimental pig experiments. It includes: an anesthesia bed, an oral cavity opening and closing assembly, a protective cover, and a wiring harness. The experimental pig lies supine on the anesthesia bed and is connected to a nasal cannula, which is externally connected to a respiratory anesthesia machine. The oral cavity opening and closing assembly is fixed to the anesthesia bed and connected to the upper and lower jaws of the experimental pig, used for opening and closing the pig's mouth and detecting the depth of anesthesia induction. The protective cover is inserted into the anesthesia bed and sealed to it, and is equipped with a one-way air inlet valve. The wiring harness passes through the anesthesia bed in a sealed manner and is connected to a monitor. A gas absorption system is provided at the tail of the anesthesia bed for absorbing any spilled isoflurane. An isoflurane detector is provided on the anesthesia bed for detecting the concentration of isoflurane gas. This invention also discloses a method for anesthetizing experimental pigs. Through this invention, the depth of anesthesia in experimental pigs can be precisely controlled, avoiding the problems of excessively deep or shallow anesthesia.

The invention relates to preparation and application of a novel trifluoroalkyl sulfur-containing phenyl heterocyclic ring derivative. Specifically, the invention relates to a compound as shown in formula (I) containing a trifluoroalkyl thiophenyl heterocyclic derivative, an isotope labeled compound of the compound, an optical isomer, a geometric isomer, a tautomer or an isomer mixture of the compound, or a pharmaceutically acceptable salt of the compound, and application of the compound in preparation of insecticides for pest control. The compound can achieve a better pest control effect at a lower dosage, especially for pests and pest mites such as tetranychus cinnabarinus, tetranychus urticae and panonychus citri.

The invention relates to the technical field of experimental medicine, and discloses a controllable hierarchical thoracic and abdominal knocking injury animal model establishment method, which comprises the following steps: S1, selecting a healthy beagle; s2, trachea cannula vein general anesthesia is conducted, a medicine injection cannula is connected with a breathing machine, and suction of 1% of isoflurane is maintained; s3, lying on the back and fixing on an experiment table with a thoracico-abdominal exposure hole; s4, a DZHE-01 injury platform is used for being aligned with the chest and the abdomen; s5, regulating pressure, grading and causing injury, and recording an overpressure curve; s6, recording indexes according to time after injury, and performing detection and image inspection. According to the method for establishing the controllable graded chest and abdomen knocking injury animal model, a healthy adult beagle is supine and fixed to an experiment table with chest and abdomen exposure holes, the upper edge of the sternum is exposed to symphysis pubis, a 5 mm nitrile rubber pad is laid on the table top, a lead plate is used for shielding the head and neck, rubber protection plates are used for shielding the limbs, and DZHE-01 platform shock waves only act on the chest and the abdomen; by combining light single-time, middle 1-2-time and heavy two-time grading injury, multiple thoracic and abdominal organ injuries are simulated, and the problem that an existing model is single in part is solved.