267 results about "Anaesthetic Agent" patented technology

A system and a method provide closed-loop sedation, anesthesia, or analgesia by monitoring EEG and automatically adjusting delivery of sedative, anesthetic, and / or analgesic drugs to maintain a desired or predetermined level of cortical at all echelons of care. The system and the method further monitor a subject's cortical activity to detect occurrence of burst suppression which can be indicative of unsafe depth of anesthesia or sedation. Further, the system and the method provide for alteration or cessation of administration of anesthesia or sedation based on the occurrence of burst suppression to mitigate harm to the subject.

The invention relates to the technical field of anesthesia management, in particular to an anesthesia medicine excess brain function influence assessment system applying artificial intelligence, which comprises a data acquisition module, a data preprocessing module, a model training module, a real-time assessment module, a risk early warning module, a treatment suggestion module, a system interaction module and a remote monitoring module. Through the combination of a convolutional neural network and a long-short-term memory network, spatial-temporal characteristics of brain wave and functional magnetic resonance imaging data are extracted, a brain function thermodynamic diagram is generated in real time, and the influence of anesthetic drugs is analyzed; the system is combined with a reinforcement learning algorithm to dynamically adjust the anesthetic dosage, a risk early warning module dynamically adjusts a threshold value through physiological parameters and tolerance of a patient, an expert team can provide medical assistance in real time through a remote monitoring module, and brain function safety of the patient in the operation or anesthesia process is ensured; according to the invention, the safety, accuracy and individuation level of anesthesia management are effectively improved.

An Adaptive Neuro-Fuzzy Inference System (ANFIS) for total intravenous anesthesia management is disclosed, enabling control over administration of anesthetic agents and dynamic adjustment according to patient physiological feedback. The system processes patient data, including processed EEG signals, hemodynamic information, capnography, and pulse oximetry, to facilitate real-time anesthetic dosage adjustments.

The invention provides a concentration-adjustable anesthesia device for the anesthesiology department. The concentration-adjustable anesthesia device aims at achieving accurate adjustment and continuous medicine supply of anesthetic concentration. The device comprises a base, a support, a central controller, a double-medicine-pushing module, a medicine liquid supply system, a monitoring instrument group and an automatic cleaning system. The central controller monitors vital sign data of a patient in real time, adjusts the anesthetic concentration according to needs, and automatically gives an alarm under abnormal conditions. The double-medicine-pushing module forms a redundant medicine supply mechanism through a first medicine pipe, a second medicine pipe and an electromagnetic valve control system, automatic switching is achieved when faults occur, and it is ensured that anesthesia is not interrupted. The liquid medicine supply system adopts a disposable medicine tank, and sterile connection is achieved through a sealing ring opening and an O-shaped ring. The device is further provided with an automatic cleaning system, alcohol is sprayed through an atomizing nozzle for internal disinfection, and a fan is arranged for rapid drying. The base is provided with walking wheels, so that the equipment can move in an operating room conveniently. The device is convenient to operate and high in reliability, and anesthesia safety and equipment maintenance convenience are effectively improved.

The invention relates to the technical field of biological pharmacy, and discloses a QS-21 saponin adjuvant as well as a preparation method and application thereof, the adjuvant is a composite liposome and comprises a liposome skeleton composed of distearoyl phosphatidylcholine and cholesterol, and QS-21 saponin, monophosphoryl lipid A and a local anesthetic are jointly entrapped in the liposome skeleton. The problem that high reactogenicity and immunogenicity of potent adjuvants are difficult to consider at the same time is solved, the immunostimulation component and the pain inhibition component are jointly entrapped in the same nano-carrier, collaborative delivery in injection local is achieved, and therefore pain and swelling caused by the adjuvants are accurately inhibited. The co-entrapment structure avoids the potential inhibition effect of the free anesthetic on the immune system, the potent body fluid and cellular immune enhancement activity of the adjuvant is completely reserved, and a new technical scheme is provided for developing vaccines with high safety and strong immune efficacy.

The invention relates to the technical field of aquatic animal living body transportation, and discloses a sea urchin long-distance transportation synergistic method based on dry transportation and anhydrous volatile anesthesia, which comprises the following steps: placing sea urchin in a closed container, using a natural volatile substance as an anesthetic, loading and volatilizing through an adsorption material, and performing anhydrous anesthesia on the sea urchin; the anesthetized sea urchin is inversely placed on a fixing support with a mesh structure in a transportation container in the posture that the mouth face faces upwards and the thorns face downwards, and the sea urchin is prevented from rolling over in the transportation process through the self-locking effect of the thorns and meshes; a functional interlayer is arranged in the fixing support, and a temperature control material and a moisturizing material are placed in the functional interlayer at the same time to maintain the temperature and humidity of the transportation environment; after transportation, the sea urchins are placed in seawater containing the cactus extract for initial recovery and then transferred to flowing natural seawater to complete unified recovery, a whole-process collaborative protection chain of anhydrous anesthesia loss prevention, dry transportation steady state maintenance and rapid water phase restoration can be constructed, and the dry transportation survival rate and quality are remarkably improved.

The invention relates to the technical field of medical care information, in particular to an anesthesia preoperative medication risk assessment method, which comprises the following steps: acquiring preoperative anesthetic dose and operation time of each historical patient and different types of physiological index data of each historical patient in different operation stages; based on the preoperative anesthetic dosage and the operation time of each historical patient, the change condition of different types of physiological index data of each historical patient in different operation stages is analyzed, and risk weights generated by anesthetic medication for different types of physiological indexes are determined; and based on the risk weight, constructing an anesthetic drug risk assessment model, and performing real-time anesthetic drug risk assessment on the patient by using the constructed anesthetic drug risk assessment model. According to the method, the risk weights generated by the anesthetic drugs for different types of physiological indexes are determined in a self-adaptive manner, and the anesthetic drug risk assessment model is constructed based on the risk weights so as to perform anesthetic drug risk assessment, so that the risk assessment accuracy is effectively improved.

The invention discloses a novel compound rapid surface anesthetic and a preparation method thereof, and belongs to the field of pharmaceutical preparations. According to the anesthetic, core anesthetic components of lidocaine and tetracaine are compounded with propylene glycol-laurocapram synergistic penetration enhancer, menthol auxiliary penetration enhancer, carbomer 980 gel matrix, triethanolamine pH regulator, glycerol humectant, panthenol soothing agent, purified water and the like, a surface smearing agent is prepared through a specific process, and the anesthetic can be administered in combination with an iontophoresis technology. Compared with the existing surface anesthetic for the cosmetic surgery, the surface anesthetic disclosed by the invention solves the problems of slow effect taking and poor effect, can realize rapid penetration of local skin, has short anesthesia effect taking time, long duration and good effect, has no obvious irritation to the skin, has good product stability, can effectively reduce the drug toxicity, and has a good application prospect. The device is suitable for surface anesthesia of non-surgical medical beauty items such as skin beauty, laser treatment and water-light micro-needles.

The invention provides a concentration-adjustable anesthesia device for the anesthesiology department, and belongs to the technical field of anesthesia. Comprising an anesthesia box, and a mixing cavity is formed in the anesthesia box. A user can firstly adjust the position of a mounting plate so as to adjust and control the effective volume of a first adjusting cavity and a second adjusting cavity, then after the anesthetic in the first adjusting cavity reaches the required content, a control assembly can drive a blocking assembly to remove blocking of a first water hole, and then the anesthetic in the second adjusting cavity reaches the required content. Then the anesthetic can automatically flow into the mixing cavity through the first water hole, and similarly, after the mixing agent in the second adjusting cavity reaches the required content, the mixing agent can flow into the mixing cavity through the second water hole, so that the adding amount of the anesthetic and the adding amount of the mixing agent can be adjusted and controlled, and the accuracy of adjusting and controlling the concentration of the anesthetic is improved; and after the anesthetic is added, the anesthetic and the mixture can automatically flow into the mixing cavity to be mixed, so that the effect of improving the use effect of the anesthetic is achieved.

The present invention relates to the technical field of medical devices, and specifically to a medical anesthesia machine capable of preventing anesthetic reflux. The present invention comprises: a main body mechanism, a drug filling mechanism and a mask mechanism. The main body mechanism comprises a columnar shell and a support frame. An anti-skid column is fixedly installed on the top of the columnar shell, an anesthetic treatment medicine tube is installed on the anti-skid column, an anesthetic treatment medicine tube is fixedly connected to the inner wall of the anesthetic treatment medicine tube with an anesthetic evaporator, and a sealing plug is slidably embedded between the anesthetic treatment medicine tube and the anesthetic evaporator. During the atomization anesthesia process, the present invention can coordinate the operation of various components of the device through an automated control system according to the patient's inhalation and exhalation states, push the atomized anesthetic gas to be delivered to the mask for the patient to inhale during inhalation, stop the delivery in time and close the corresponding passage during exhalation, so that the anesthetic delivery is synchronized with the patient's breathing, which not only ensures the anesthesia effect but also greatly reduces the possibility of anesthetic reflux caused by reverse pressure difference.

The utility model relates to the technical field of medical instruments, in particular to a clinical anesthetic storage device which comprises a heat preservation mechanism and a plurality of storage mechanisms, the heat preservation mechanism comprises a heat preservation box, the storage mechanisms are symmetrically installed in the heat preservation box, and the heat preservation mechanism further comprises a partition plate and a cover plate. The partition plate is fixedly connected to the inner side wall of the heat preservation box, the cover plate is arranged at the top of the heat preservation box, and a plurality of first threaded holes are evenly formed in the upper surface of the cover plate; in the using process, when anesthetic in the heat preservation box is taken out, the cover plate does not need to be opened, the cover body is rotated, the cover body is rotated out of the first threaded hole, the cover body adsorbs the first magnetic block through the second magnetic block to drive the storage barrel to move, the storage barrel is taken out of the first threaded hole, and then the needed anesthetic can be taken out independently; when the anesthetic is taken out, a large amount of cold air is not lost, and the temperature in the heat preservation box can be kept relatively stable.

The present invention relates to a soluble microneedle for local anesthesia and a local anesthesia patch comprising same, the soluble microneedle comprising an amide-based local anesthetic, hyaluronic acid, and polyvinylpyrrolidone in a specific content ratio. The present invention uses the soluble microneedle to implement direct drug delivery by physically permeating through the stratum corneum and mucosa, and thus a precise and rapid anesthetic effect may be exhibited. Especially, the microneedle comprising a specific amount of polyvinylpyrrolidone is dissolved, and the anesthetic contained in the microneedle is rapidly delivered to nerve cells, and thus the disadvantage of a long waiting time of conventional anesthetic creams may be overcome, and thus the present invention has the advantage of being usable in various ways in dental, dermatology, and other surgical procedures requiring local anesthesia.

The invention provides an analgesic microneedle patch based on 3D printing and a preparation method and application thereof, and belongs to the technical field of biomedical materials.The preparation method of the hydrogel microneedle patch based on 3D printing comprises the following steps that 1, cold water fish skin gelatin is dissolved in DPBS, and a gelatin solution is obtained; (2) mixing methacrylic anhydride and gelatin liquid to generate polymerization reaction, so as to obtain a hydrogel material; and 3) loading an anesthetic and analgesic drug on the hydrogel material, and printing by a photocuring 3D printing method to obtain the hydrogel microneedle patch. The 3D printing technology is combined with a microneedle which is a dysmenorrhea-free skin drug delivery system, local anesthetics are loaded into the microneedle patch, on the basis of painless drug delivery, the drug delivery efficiency is improved, the drug onset time is shortened, and then the effect of effectively, rapidly and safely playing a local anesthesia role is achieved.

The invention relates to particular prodrugs and analogs of (3α,5α)-3-hydroxy-21-(1H-imidazol-1-yl)-3-methoxymethyl)-pregnan-20-one, in free or pharmaceutically acceptable salt and / or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use as sedatives, hypnotics, anxiolytics, and / or anesthetics, and methods for treatment of depression, anxiety, insomnia, epilepsy, and other central nervous system disorders, as well as to combinations with other agents.

The invention discloses a low-stress bleeding processing method for channel catfish. The method comprises the following steps: an acid-base control step, in which the channel catfish is placed in water containing sodium citrate to control the acid-base in the body, thereby increasing the alkali reserve in the body of the fish; a combined light anesthesia step, in which the channel catfish is lightly anesthetized through the combined action of low temperature and a chemical anesthetic, so that the fish exhibits a state in which the gill cover of the fish opens and closes weakly and slowly, and the fish body rolls over and loses balance; a fish body puncture step, in which the blood circulation of the channel catfish is destroyed by a manual or mechanical method, thereby creating a bleeding wound on the fish body; a metabolic bleeding step, in which the fish body is placed in a bleeding tank that has been aerated and oxygenated in advance to saturated dissolved oxygen, for bleeding, while maintaining a certain dissolved oxygen concentration; and an ultrasonic blood purification step, in which the fish body is placed in a bleeding tank equipped with an ultrasonic device for bleeding, thereby accelerating the discharge of residual blood in the body.

The invention relates to a breathing system and a breathing method for artificial respiration of a patient. The invention further relates to a control assembly and a control method for controlling a breathing assembly belonging to a breathing system. The anesthetic meter member (38) provides an anesthetic gas mixture (Ng) having a predetermined theoretical concentration (conreq) of the anesthetic (Nm). The respirator (12) delivers a breathable gas mixture with an anesthetic gas mixture (Ng) to the patient-side coupling unit. The setpoint concentration (conreq) is specified in such a way that the setpoint concentration is at most equal to the calculated upper concentration limit (conmax). The higher the temperature in the anesthetic meter member (38), in the ventilator (12) and / or in the ambient environment, the higher the concentration upper limit (conmax). The present invention reduces the risk of anesthetic (Nm) coagulation.

A system (100) and method (1000) for managing fluid administration to a patient (120) following administration of an anaesthetic. The system (100) comprises a processor (112) configured to receive monitored patient haemoglobin data before and after the administration of the anaesthetic. The processor (112) is configured to calculate a baseline blood volume (BBV) of the patient (120). After administration of the anaesthetic, the processor (112) is configured to calculate a target blood volume (TBV), wherein the target blood volume (TBV) is calculated by comparing the monitored patient haemoglobin data before and after the administration of the anaesthetic.

The invention relates to the field of anesthetic quantification, in particular to an anesthetic quantitative conveying device of an anesthesia machine in an operating room, which comprises a table top, a bottom plate, a box body, a quantitative groove and a buffer groove, the bottom plate is fixed at the upper end of the table top, the box body is fixed at the upper end of the bottom plate, the quantitative groove is arranged on one side of the box body, and a piston I is arranged in the quantitative groove; and a lead screw is rotationally installed at the upper end of the first piston, a movable frame is rotationally installed at the end, penetrating through the upper end of the quantitative groove, of the lead screw, a mounting frame is arranged on one side of the quantitative groove, a height-adjustable lifting frame is connected to the mounting frame in an inserted mode, and a buffer groove is formed in the upper end of the lifting frame. The height of the piston can be adjusted by driving the screw rod through the motor, precise quantification is realized by combining infrared distance measurement, negative pressure is formed by utilizing the design of the piston II and the spring of the buffer groove, liquid medicine is prevented from flowing back and dripping, and the operation convenience and the medicine utilization rate are improved; the problem that an existing anesthetic quantifying device for the operating room lacks accurate quantifying and liquid leakage preventing functions is solved.

A novel active agent-eluting hemostatic agent and methods of use and manufacture thereof are presented. A polymer, such as gelatin, is used as the base for a hemostatic agent. The gelatin is crosslinked with a chemical crosslinker, such as a carbodiimide, in the presence of an active agent. The active agent may be an anesthetic or antimicrobial, such as an antibiotic. The novel process allows for the active agent to be both covalently bound to the gelatin as well as be trapped within cages in the gelatin that are formed from the crosslinking. This dual measure allows for controlled and sustained release of the active agent from the hemostatic agent to reduce surgical site infections.

The topical composition is for application to a portion of skin at a locus of postsurgical pain and comprises: an amount of anti-inflammatory analgesic; an amount of muscle relaxant; an amount of neuropathic analgesic; an amount of anesthetic; and a carrier having skin penetration enhancement qualities.

The present invention belongs to the technical field of biomedicine, and particularly relates to an anesthetic preparation containing trimecaine and a preparation method thereof. The anesthetic preparation containing trimecaine comprises the following raw materials in parts by weight: 8-12 parts of trimecaine, 0.5-1 part of lindenenolide, 0.3-0.8 part of sodium phytate, 1-5 parts of schizophyllan oligosaccharide, 3-5 parts of 1,2-propanediol, 2-6 parts of sodium carboxymethylcellulose, 3-8 parts of Tween, and 60-70 parts of physiological saline. The combination of lindenenolide and trimecaine added in the anesthetic preparation of the present invention can improve the anesthetic effect and prolong the anesthetic time. Sodium phytate and schizophyllan oligosaccharide in the anesthetic preparation act synergistically to effectively improve the stability of the anesthetic preparation. Among them, due to the film-forming property of schizophyllan oligosaccharide, it can also improve the anesthetic efficacy of the anesthetic preparation to a certain extent. In addition, the anesthetic prepared by the present invention has no obvious irritation to the skin.

The invention relates to the technical field of syringes, and discloses an anesthetic syringe which comprises a needle cylinder, and the outer wall of the needle cylinder is fixedly sleeved with a limiting wing ring; the connecting mechanism is arranged on the needle cylinder, and the connecting mechanism is used for disassembling and assembling the needle cylinder; the constant-speed pushing mechanism is arranged on the connecting mechanism, and the constant-speed pushing mechanism is used for stably pushing the anesthetic; the constant-speed pushing mechanism comprises a strip-shaped frame piece, and a lead screw is rotationally connected to the inner wall of the strip-shaped frame piece. Through the cooperative design of the constant-speed pushing mechanism and the connecting mechanism, a needle cylinder loaded with anesthetics can be fixed by means of the connecting mechanism, a user can hold the needle cylinder from the grip with one hand and rotate the rotating wheel with the other hand, the pushing block can be driven to translate at a relatively constant speed by rotating the rotating wheel, and a piston is pushed at a constant speed; the stability of injection work is improved, and the discomfort of a patient in the injection process is remarkably reduced.

1. The name of the design product: medical anesthetic needle. 2. The use of the design product: the design product is used as a puncture device for medical anesthesia and an injection channel for anesthetic. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

A topical ophthalmic anesthetic composition includes a formulation with an amount of articaine to provide anesthetic properties when applied topically to the eye, and a pH, viscosity, osmolality, dissociation constant, and additives such as antioxidants, buffers, methylcellulose, to achieve efficacy and safety. The composition can contain articaine in amounts of about 4.0% w / v to about 12.0% w / v and have a pH of about pH 3.5 to pH 7.0. The buffer can be borate / mannitol complex obtained from boric acid or salt thereof and D-mannitol. The articaine formulations can achieve adequate anesthesia of the internal aspect of the eye wall by topical application, without the use of an injectable anesthetic. Exemplary implementations of the disclosure include formulations include articaine in an amount of at least 7.0% w / v, where the formulation is an aqueous solution, a gel, an ointment, or in an encapsulated form.

The utility model relates to the technical field of anesthesia, and discloses an anesthetic spraying device for anesthesiology department nursing, which comprises a shell, the inner wall of the shell is fixedly connected with a medicine storage bin, the inside of the medicine storage bin is fixedly connected with a breather pipe, the inner wall of the medicine storage bin is fixedly connected with a conical barrel, the inside of the medicine storage bin is fixedly connected with a medicine inlet pipe, and the inner wall of the medicine inlet pipe is fixedly connected with an air outlet pipe. The outer portion of the medicine inlet pipe is fixedly connected to the interior of the shell, the inner wall of the conical barrel is fixedly connected with an air conveying pipe, the inner wall of the shell is fixedly connected with a micro air pump, and the output end of the micro air pump is fixedly connected to the outer wall of the air conveying pipe. The miniature air pump is started, the valve is opened, the air pump pumps out oxygen and sends the oxygen into the conical barrel, gas exhaust is accelerated, high-speed airflow drives anesthetic in the medicine storage bin to move towards the medicine conveying pipe, the anesthetic flows out smoothly, and due to the design, the device can run automatically, spraying of aerial fog is prevented from being uneven, and the effect of spraying anesthetic aerial fog in a full-automatic mode is achieved.

The utility model belongs to the field of medicine trays, and particularly relates to an anesthetic tray for an anesthetist. The medicine bottle tray comprises a horizontally-arranged tray body, a mounting plate is horizontally arranged above the tray body, a fixing assembly used for fixing the mounting plate to the tray body is arranged between the mounting plate and the tray body, a plurality of through holes which are communicated up and down are formed in the mounting plate, and two clamping plates which can swing up and down and are used for clamping medicine bottles are hinged into each through hole. A return assembly used for returning the two clamping plates which swing downwards to the horizontal state is arranged at the bottom of the mounting plate and corresponds to each through hole, and a plurality of containing holes used for allowing medicine bottles to penetrate through are formed in the mounting plate. The return assembly pushes the two clamping plates which swing downwards to swing upwards and reset, so that the two clamping plates clamp and fix a medicine bottle containing anesthetic, and the situation that when the medicine bottle or an anesthesia disc is impacted, the medicine bottle turns over, and the anesthetic is spilled out is prevented.

The utility model belongs to the anus operation technical field, concretely is the surface anesthesia dressing of anus operation postoperative dressing change, including dressing body, the dressing body is by the bottom dressing stem body and the top dressing umbrella body integration and is composed, the inner middle part of dressing stem body forms and has the filling cavity, the inside fixed plug of filling cavity has the soft rubber tube, the inner middle part of soft rubber tube forms and has the pressure slot hole, this dressing avoids using the ointment type anesthetic, will not influence the patient activity and avoids using the ointment type anesthetic and leads to difficult to clean, convenient to use, can alleviate the patient's distress.

The present invention relates to a hydrogel comprising at least one hyaluronic acid or a salt thereof, crosslinked and / or non-crosslinked, at least one anesthetic and at least one thiosulfate salt. The invention also relates to the use of the hydrogel according to the invention in the prevention and / or cosmetic treatment of an alteration of the surface appearance of the skin.

Selectively controllable apparatus for insertion into an ear canal, and related methods of use and operation for behavioral control. In one embodiment, the apparatus includes a body configured for insertion into an ear canal. In one variant, the body includes one or more thermal mechanisms which enable selective increase or decrease of temperature of at least portions of the ear canal so as to implement behavioral control of the user, such as to mitigate cravings for food, alcohol, narcotics, or other potentially deleterious substances. In one variant, a mild nausea or pre-nausea condition is created within the user according to a time-temperature profile so as to induce the aforementioned behavioral modification.

The invention relates to an anaesthetic dispenser (100) having a feed unit (9) and an anaesthetic tank (7). In the feed unit, anaesthetic from the anaesthetic tank (7) is mixed with a carrier gas. Liquid anaesthetic (Nm) can be refilled into the anaesthetic tank (7) through a refill opening (6). A predefined operating pressure is maintained in the operating mode. A closure (16) can be moved from a closed position via an intermediate position into an open position and closes the refill opening (6) in both the closed position and the intermediate position. A transition period elapses when the closure (16) is moved from the closed position into the intermediate position. A position sensor (22) detects the event that the closure (16) has moved out of the closed position. In response to this detection, the pressure in the anaesthetic tank is reduced during the transition period to a refill pressure which is still higher than the ambient pressure. The closure (16) is then opened.