121 results about "Anaesthetic Agent" patented technology

The invention relates to the technical field of biological pharmacy, and discloses a QS-21 saponin adjuvant as well as a preparation method and application thereof, the adjuvant is a composite liposome and comprises a liposome skeleton composed of distearoyl phosphatidylcholine and cholesterol, and QS-21 saponin, monophosphoryl lipid A and a local anesthetic are jointly entrapped in the liposome skeleton. The problem that high reactogenicity and immunogenicity of potent adjuvants are difficult to consider at the same time is solved, the immunostimulation component and the pain inhibition component are jointly entrapped in the same nano-carrier, collaborative delivery in injection local is achieved, and therefore pain and swelling caused by the adjuvants are accurately inhibited. The co-entrapment structure avoids the potential inhibition effect of the free anesthetic on the immune system, the potent body fluid and cellular immune enhancement activity of the adjuvant is completely reserved, and a new technical scheme is provided for developing vaccines with high safety and strong immune efficacy.

The invention discloses a novel compound rapid surface anesthetic and a preparation method thereof, and belongs to the field of pharmaceutical preparations. According to the anesthetic, core anesthetic components of lidocaine and tetracaine are compounded with propylene glycol-laurocapram synergistic penetration enhancer, menthol auxiliary penetration enhancer, carbomer 980 gel matrix, triethanolamine pH regulator, glycerol humectant, panthenol soothing agent, purified water and the like, a surface smearing agent is prepared through a specific process, and the anesthetic can be administered in combination with an iontophoresis technology. Compared with the existing surface anesthetic for the cosmetic surgery, the surface anesthetic disclosed by the invention solves the problems of slow effect taking and poor effect, can realize rapid penetration of local skin, has short anesthesia effect taking time, long duration and good effect, has no obvious irritation to the skin, has good product stability, can effectively reduce the drug toxicity, and has a good application prospect. The device is suitable for surface anesthesia of non-surgical medical beauty items such as skin beauty, laser treatment and water-light micro-needles.

The invention relates to a breathing system and a breathing method for artificial respiration of a patient. The invention further relates to a control assembly and a control method for controlling a breathing assembly belonging to a breathing system. The anesthetic meter member (38) provides an anesthetic gas mixture (Ng) having a predetermined theoretical concentration (conreq) of the anesthetic (Nm). The respirator (12) delivers a breathable gas mixture with an anesthetic gas mixture (Ng) to the patient-side coupling unit. The setpoint concentration (conreq) is specified in such a way that the setpoint concentration is at most equal to the calculated upper concentration limit (conmax). The higher the temperature in the anesthetic meter member (38), in the ventilator (12) and / or in the ambient environment, the higher the concentration upper limit (conmax). The present invention reduces the risk of anesthetic (Nm) coagulation.

The invention relates to the technical field of syringes, and discloses an anesthetic syringe which comprises a needle cylinder, and the outer wall of the needle cylinder is fixedly sleeved with a limiting wing ring; the connecting mechanism is arranged on the needle cylinder, and the connecting mechanism is used for disassembling and assembling the needle cylinder; the constant-speed pushing mechanism is arranged on the connecting mechanism, and the constant-speed pushing mechanism is used for stably pushing the anesthetic; the constant-speed pushing mechanism comprises a strip-shaped frame piece, and a lead screw is rotationally connected to the inner wall of the strip-shaped frame piece. Through the cooperative design of the constant-speed pushing mechanism and the connecting mechanism, a needle cylinder loaded with anesthetics can be fixed by means of the connecting mechanism, a user can hold the needle cylinder from the grip with one hand and rotate the rotating wheel with the other hand, the pushing block can be driven to translate at a relatively constant speed by rotating the rotating wheel, and a piston is pushed at a constant speed; the stability of injection work is improved, and the discomfort of a patient in the injection process is remarkably reduced.

1. The name of the design product: medical anesthetic needle. 2. The use of the design product: the design product is used as a puncture device for medical anesthesia and an injection channel for anesthetic. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

The utility model belongs to the field of medicine trays, and particularly relates to an anesthetic tray for an anesthetist. The medicine bottle tray comprises a horizontally-arranged tray body, a mounting plate is horizontally arranged above the tray body, a fixing assembly used for fixing the mounting plate to the tray body is arranged between the mounting plate and the tray body, a plurality of through holes which are communicated up and down are formed in the mounting plate, and two clamping plates which can swing up and down and are used for clamping medicine bottles are hinged into each through hole. A return assembly used for returning the two clamping plates which swing downwards to the horizontal state is arranged at the bottom of the mounting plate and corresponds to each through hole, and a plurality of containing holes used for allowing medicine bottles to penetrate through are formed in the mounting plate. The return assembly pushes the two clamping plates which swing downwards to swing upwards and reset, so that the two clamping plates clamp and fix a medicine bottle containing anesthetic, and the situation that when the medicine bottle or an anesthesia disc is impacted, the medicine bottle turns over, and the anesthetic is spilled out is prevented.

The utility model belongs to the anus operation technical field, concretely is the surface anesthesia dressing of anus operation postoperative dressing change, including dressing body, the dressing body is by the bottom dressing stem body and the top dressing umbrella body integration and is composed, the inner middle part of dressing stem body forms and has the filling cavity, the inside fixed plug of filling cavity has the soft rubber tube, the inner middle part of soft rubber tube forms and has the pressure slot hole, this dressing avoids using the ointment type anesthetic, will not influence the patient activity and avoids using the ointment type anesthetic and leads to difficult to clean, convenient to use, can alleviate the patient's distress.

The present invention relates to a hydrogel comprising at least one hyaluronic acid or a salt thereof, crosslinked and / or non-crosslinked, at least one anesthetic and at least one thiosulfate salt. The invention also relates to the use of the hydrogel according to the invention in the prevention and / or cosmetic treatment of an alteration of the surface appearance of the skin.

Selectively controllable apparatus for insertion into an ear canal, and related methods of use and operation for behavioral control. In one embodiment, the apparatus includes a body configured for insertion into an ear canal. In one variant, the body includes one or more thermal mechanisms which enable selective increase or decrease of temperature of at least portions of the ear canal so as to implement behavioral control of the user, such as to mitigate cravings for food, alcohol, narcotics, or other potentially deleterious substances. In one variant, a mild nausea or pre-nausea condition is created within the user according to a time-temperature profile so as to induce the aforementioned behavioral modification.

The invention relates to an anaesthetic dispenser (100) having a feed unit (9) and an anaesthetic tank (7). In the feed unit, anaesthetic from the anaesthetic tank (7) is mixed with a carrier gas. Liquid anaesthetic (Nm) can be refilled into the anaesthetic tank (7) through a refill opening (6). A predefined operating pressure is maintained in the operating mode. A closure (16) can be moved from a closed position via an intermediate position into an open position and closes the refill opening (6) in both the closed position and the intermediate position. A transition period elapses when the closure (16) is moved from the closed position into the intermediate position. A position sensor (22) detects the event that the closure (16) has moved out of the closed position. In response to this detection, the pressure in the anaesthetic tank is reduced during the transition period to a refill pressure which is still higher than the ambient pressure. The closure (16) is then opened.

The utility model relates to the technical field of anesthesia, in particular to an anesthetic concentration adjusting device which comprises a base, a rotating shaft and a rotating shaft. The turntable is rotationally arranged on the base; the upper end of the mixing pipe is opened, the mixing pipe is detachably connected to the rotating disc, and the mixing pipe can rotate along with the rotating disc; the piston is detachably connected with the mixing pipe, is rotationally mounted on the mixing pipe and can seal the opening of the mixing pipe; the stock solution tank is connected to the piston and is communicated with the mixing pipe; the diluting tank is connected to the piston and is communicated with the mixing pipe; and the electromagnetic valves are arranged between the stock solution tank and the piston and between the dilution tank and the piston. The device has the effects that the mixing pipe can be conveniently detached, and the mixing pipe can be conveniently cleaned.

The present invention relates to a spinal needle that clearly identifies the presence of cerebrospinal fluid (CFS) to dispense a drug or anaesthetic in the correct direction and site of the meninges. The response of the sensor to the presence of CFS does not depend on environmental factors and is performed quickly to prevent excessive loss of CFS in the patient. The spinal needle comprises a hub having a proximal end and a distal end, said hub comprising a transparent tank arranged at the proximal end of the hub that is configured to receive CFS, an expandable CFS sensor arranged inside the transparent tank and a connection port arranged at the distal end of the hub configured to couple to a device for medical fluids, and a cannula comprising a tip fluidically connected to the proximal end of the hub.

Biomaterials, implants, methods of making the biomaterial and implants, methods of providing pain relief by administering the biomaterial or implant to a patient, and kits that include such biomaterials, implants, or components thereof. The biomaterials may include microparticles including one or more active pharmaceutical agents, such as anesthetics, antibiotics, and corticosteroids, which help to provide pain relief over an extended period of time. The biomaterials may be applied directly to the intervertebral disc or in the disc space to provide direct therapy for the management of disc pain.

The invention relates to the technical field of injectors, and discloses an anesthetic dosage controllable injector which comprises a barrel, a plunger is slidably mounted in the barrel, two symmetrically arranged convex edges are fixedly mounted at the top end of the outer circle face of the plunger, and dosage scales are arranged on the barrel. The sleeve plate and the push plate move synchronously, at the moment, the position of the limiting plate on the barrel is adjusted, the limiting plate can accurately limit movement of the sleeve plate, then the injection dosage is controlled, before injection every time, the locking assembly is adjusted to be in an unlocking state, the push plate can move independently, and therefore a small part of anesthetic is squeezed out to be used for exhausting air, and when the push plate abuts against the sleeve plate, the injection dosage is controlled. When the anesthetic is injected, the anesthetic stops moving, which means that the air is completely exhausted, so that the volume change of the anesthetic does not need to be observed all the time when the dose injection is controlled, and the operation process of exhausting the air in the anesthetic in the injection interval is greatly simplified.

Provided is a pharmaceutical composition for use in treating postsurgical pain. The pharmaceutical composition comprises a lipid-based complex. The lipid-based complex comprises an amide-type anesthetic and at least one lipid, wherein a molar ratio of the amide-type anesthetic to the at least one lipid of the lipid-based complex is at least 0.5:1. The total amount of the amide-type anesthetic is at least 1.5 to 5 times of a standard therapeutic dose for treating postsurgical pain with the amide-type anesthetic to achieve an improved pain control with desired prolonged analgesic effect.

A malleable sustained release formulation is created utilizing a local anesthetic wherein the composition is made sustained release by incorporating it into a bovine or porcine hemostatic agent. The composition is malleable enough to fit into a cavity such as a dental cavity and form the shape of the cavity. In addition to providing sustained release of the anesthetic, the composition also provides quicker reduction in bleeding.

A method for applying a regional block of the articular sensory branch of femoral (FN), obturator (ON) and accessory obturator nerves (AON) comprising injection of an anesthetic at a single needle entry point into a these nerves anatomical sites. Another aspect of this technology is a kit for performing this method.

A composition of the present invention relates to a liposuction composition comprising: a basic solution containing NaCl; an anesthetic; and albumin. The composition of the present invention has the effect of improving the extraction yield and cell viability of adipose stem cells. In particular, stem cells present in adipose tissue can be efficiently isolated using the composition of the present invention. Since fat in the body can be effectively and safely aspirated, the present invention has high industrial applicability.

Disclosed herein is an advanced anesthetic gel formulation designed for painless, non-invasive dental procedures. The gel incorporates lidocaine hydrochloride and prilocaine hydrochloride as the primary anesthetics, supported by carbomer 940 for viscosity control. Sodium chloride is added to improve electrical conductivity, while triethanolamine maintains an optimal pH balance. Glycerin functions as a humectant to reduce tissue irritation, and allantoin offers anti-inflammatory properties. Phenoxyethanol is included to prevent microbial growth, ensuring the gel's safety and stability. The preparation method involves dissolving these components in purified water, creating a gel that enables effective, non-invasive dental anesthesia through iontophoresis, significantly enhancing patient comfort and procedural efficiency.

The invention relates to a transmission desorption electrospray low-pressure ion mobility spectrometry which comprises a transmission desorption electrospray ion source, an interface electrode and a low-pressure ion migration tube, the interface electrode is a metal sheet electrode with a through hole in the center, and the transmission desorption electrospray ion source is connected with the low-pressure ion migration tube through the interface electrode. The ion mobility spectrometry can realize efficient desorption spray ionization of substances difficult to volatilize in the detection process, the sample detection process is simplified, the working air pressure is lower than the atmospheric pressure, the detection sensitivity can be improved, furthermore, the ion mobility spectrometry is provided with a desolvation area and is combined with desolvation gas, the detection sensitivity can be further improved, and the detection accuracy is improved. High-sensitivity detection of anesthetic drugs such as propofol, etomidate, fentanyl and the like in blood can be realized through transmission-type desorption electrospray and low-pressure ion mobility spectrometry.

The invention relates to the technical field of medical instruments, in particular to an inhalation anesthetic doser which comprises a doser body, the doser body comprises a bottle sealing gasket, a spring support, a spring, a spring seat, a doser inner sealing gasket, a sliding rod, a doser body, an O-shaped ring, a doser cover sealing gasket and a doser cover. The spring seat and the sliding rod are in interference fit to form a combined body I; a sealing gasket in the doser is fixed at the joint of the spring seat and the sliding rod, the spring is arranged on the spring seat, a core rod of the spring seat penetrates through a central hole of the spring frame, the first combination body penetrates into the central hole of the doser body from the top, and the contact surface of the spring frame and the doser body is fastened and connected; the spring seat, the doser inner sealing gasket and the sliding rod form a combined body II; the automatic medicine adding device has the functions of uniqueness recognition of medicine, closed medicine adding and repeated use, the automatic medicine adding function is achieved under the medicine adding opening of a matched structure, operation errors and medicine waste are avoided, environmental pollution is reduced, and physical labor of medical staff is reduced.

The present invention relates to a free-flowing topical powder formulation, also known as a powder-to-cream formulation. The invention particularly relates to a powder-formula that spreads on the skin like a cream upon application. The invention offers an ideal topical formulation with the advantages of both a powder and a cream, combining the ease of handling of the powder with the smoothness and spreadability of a cream, and is a better choice for multiple topically applied active ingredients. The present invention provides a technology for delivering various active ingredients from categories that include, among others, antiviral agents, acne treatment agents, alpha hydroxy acids, anesthetics, antibacterial agents, antifungals, etc.

Provided herein are methods, compositions, kits, and systems for treating depression and / or producing an electroencephalogram (EEG) profile using a combination of anesthetics. The combination of anesthetics may include a NMDA-type glutamatergic receptor antagonist anesthetic, a GABAergic anesthetic, or a α2-adrenergic receptor agonist anesthetic.

A cushioning container for cushioning an anesthetic cartridge may include a housing having a hollow body, a closed distal end having a cartridge cartridge, and an opening opposite the closed distal end. The buffer container may also include a buffer solution disposed within the cartridge bin and a flexible piston disposed within the cartridge bin and maintained in sealing contact with the buffer solution, wherein the flexible piston is axially movable within the housing. The buffer container can further comprise a puncture needle seat which axially moves in the shell and makes contact with the flexible piston, and the puncture needle seat comprises a puncture needle fixedly connected to the puncture needle seat. The flexible piston can receive a first tip of a puncture needle. A buffer solution placed in the cartridge clamping bin can be in fluid communication with anesthetic liquid in the anesthetic cartridge through the puncture needle. A method of buffering an anesthetic cartridge is also disclosed.

This invention provides a method for the reductive synthesis of tetracaine via amination, belonging to the field of organic synthesis. Using methyl p-aminobenzoate and butyraldehyde as raw materials, and a borane complex as a hydrogen transfer reagent, this invention synthesizes the medical anesthetic tetracaine via reductive amination. The main advantages of this method are: no catalyst required, high yield, mild reaction conditions, short reaction time, and high overall yield. Therefore, the method provided by this invention offers an effective approach for the future synthesis of tetracaine.

Polymeric particles and scaffolds containing anesthetic agents, their use for sustained local delivery of anesthetic agents, reduction of pain killer addiction and addiction risk, and methods of fabricating and administering polymeric particles containing anesthetic agents are described herein.

An article of manufacture according to the present invention comprises a composition including a glycosaminoglycan, a local anesthetic, and a buffer packaged in a syringe or vial constructed from either glass or a plastic selected from the group consisting of cyclic olefin polymer, cyclic olefin copolymer, or high density non-nucleated polypropylene. The composition has unexpectedly improved stability on storage. The composition can be formulated for treatment of a urinary tract disease or condition, such as interstitial cystitis, also known as bladder pain syndrome or hypersensitive bladder syndrome.

This disclosure discloses a composition for treating pain in a subject requiring it, comprising an emulsion comprising an aqueous carrier; a liquid lipid phase dispersed as droplets in the aqueous carrier; and a first anesthetic in the lipid phase. In certain embodiments, the first anesthetic comprises a plurality of first anesthetic crystals. In certain alternative embodiments, the first anesthetic is dissolved in the lipid phase. In certain embodiments, the composition further comprises a plurality of second anesthetic crystals in the aqueous carrier rather than in the lipid phase, the second plurality of anesthetics dissolve and elute from the emulsion at a faster rate than the first plurality of anesthetic crystals. In certain embodiments, the composition further comprises one or more additional anesthetics different from the first anesthetic.

The invention provides an inhalation anesthetic adding and storing device, and relates to the field of medical instruments. The device comprises a sealing plug assembly, a medicine injection port assembly, a medicine injection port sheath, a first screw, a push rod assembly, a spring body, a medicine storage body assembly, a liquid level sensor, a heating rod assembly, an outlet filter element, a first O-shaped ring, a second O-shaped ring, a pressure sensor, a second screw, a third O-shaped ring, a temperature sensor and a set screw. The sealing plug assembly is inserted into the medicine injection opening assembly and is unlocked, inserted, pulled out and locked through a related structure of the medicine injection opening assembly, and the medicine injection opening assembly penetrates through the medicine injection opening protective sleeve and is fixed to the corresponding thread position of the medicine storage body assembly through three first screws. By adopting automatic locking and pressing unlocking modes, the operation steps of the medicine adding process are simplified, the safety of the medicine adding process is improved, meanwhile, the labor intensity of medical staff is reduced, and the convenience of the medicine adding process is also improved.