The invention provides a modeling method and application of a simple anaphylactoid purpura
animal model. The modeling method comprises the following steps: adaptively feeding SPF rats for 3 days; the hot
traditional Chinese medicine is continuously injected into the
stomach for 7 days, and 1mL / 100g body
mass is injected every day; on the seventh day and the fourteenth day, an
abdominal cavity sensitizer is injected to the
abdominal cavity of the rat twice; shaving a local area on the back of the rat on the 25th day, performing
inhalation anesthesia on the rat, performing
warm water local wet compress, and then removing local stubbles by using a scraper; injecting a
caudal vein sensitizer into the
caudal vein of the rat; and after 30 minutes,
intradermal injection of an intradermal sensitizer is carried out, 4-5 points are divided, waiting is carried out for 24 hours, so that the
antigen is completely excited, and molding is completed. The hot
traditional Chinese medicine comprises the following raw materials: cinnamon, fructus piperis longi and rhizoma zingiberis. The modeling time is shorter, the modeling rate is high, the cost is lower, and blood routine,
renal function,
immunity and
inflammation index detection results and
skin and
kidney pathological results of model rats are all highly similar to those of simple / blood-heat syndrome anaphylactoid purpura patients.