The invention relates to the field of environmental protection devices, and concretely discloses a cyclone redistribution denitration reactor for flue gas. The cyclone redistribution denitration reactor comprises a flue gas inlet tube, a cyclone assembly for guiding flue gas, an ammonia spraying and mixing device, a connecting flue gas tube, a catalytic reaction device and a flue gas outlet tube which are sequentially interconnected, the cyclone assembly comprises a first shell, the flow guiding plates and a mounting plate, the flow guiding plates have a spiral fan blade shape, the flow guiding plates are connected to the inner wall of the first shell, and are arranged along the circumferential direction of the first shell, the quantity of the flow guiding plates is more than one, the rotating directions of all the flow guiding plates are same to each other, the mounting plate is positioned among all the flow guiding plates, and the mounting plate is fixedly connected to one ends, facing the center of the first shell, of all the flow guiding plates. Flue gas enters the cyclone assembly through the flue gas inlet tube, and moves along the flow guiding plates to form a uniform-rotating flue gas flow, so the flue gas is in a uniformly distributed state when moving to the ammonia spraying and mixing device, thereby the flue gas is well contacted and reacted with a reaction solutionsprayed by the ammonia spraying and mixing device, dead angles are reduced, and the denitration efficiency is improved.