Inhalational compound anaesthetic agent

An anesthetic and inhalation technology, applied in the direction of anesthetic, drug combination, drug delivery, etc., can solve problems such as difficult to control the depth and maintenance time of anesthesia, difficult to apply complex and long-term surgery, respiratory and circulatory system effects, etc., to achieve rapid induction Stable, flexible and controllable anesthesia maintenance, quick recovery effect

Inactive Publication Date: 2015-05-20
黄玉华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problems in the above-mentioned prior art and to develop an inhaled compound anesthetic in combination with the clinical needs of anesthesia. By emulsifying nitrous oxide, Several kinds of drugs such as Dajinhua, Aconitum, and Sevoflurane are scientifically formulated to achieve a reasonable and good anesthesia effect, and at the same time minimize the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A kind of inhalation type compound anesthetic is characterized in that: described inhalation type anesthetic comprises A agent and B agent,

[0016] The content of nitrous oxide in the described agent A is 1%, the content of the composite emulsifier is 15%, and the content of the spice is 0.1%; The content of halothane is 2%, the content of complex emulsifier is 20%, and the content of fragrance is 0.1%.

[0017] Preferably, the composite emulsifier is made by compounding Span 80, Tween 80 and Capstone FS-63, wherein the ratio of Span 80, Tween 80 and Capstone FS-63 is 0.4:1:0.5.

[0018] Preferably, the jasmine flower is made into particles with a particle size of 10 μm.

[0019] Preferably, the Radix Cauliflower is made into particles with a particle size of 10 μm.

Embodiment 2

[0021] A kind of inhalation type compound anesthetic is characterized in that: described inhalation type anesthetic comprises A agent and B agent,

[0022] In the described agent A, the content of nitrous oxide is 1.5%, the content of the composite emulsifier is 20%, and the content of the spice is 0.2%; The content of 100mL of sevoflurane is 2.1%, the content of compound emulsifier is 20%, and the content of fragrance is 0.1%.

[0023] Preferably, the composite emulsifier is made by compounding Span 80, Tween 80 and Capstone FS-63, wherein the ratio of Span 80, Tween 80 and Capstone FS-63 is 0.4:1:0.5.

[0024] Preferably, the jasmine flower is made into particles with a particle size of 10 μm.

[0025] Preferably, the Radix Cauliflower is made into particles with a particle size of 10 μm.

Embodiment 3

[0027] An inhalation type compound anesthetic, the nitrous oxide content in the described agent A is 5%, the compound emulsifier content is 25%, and the spice content is 0.3%; The content of Caowu is 0.3g / 100mL, the content of sevoflurane is 2.5%, the content of compound emulsifier is 25%, and the content of fragrance is 0.1%.

[0028] Preferably, the composite emulsifier is made by compounding Span 80, Tween 80 and Capstone FS-63, wherein the ratio of Span 80, Tween 80 and Capstone FS-63 is 0.4:1:0.5.

[0029] Preferably, the jasmine flower is made into particles with a particle size of 1 μm.

[0030] Preferably, the Caowu is made into particles with a particle size of 1 μm.

[0031] When using this compound anesthetic, either intravenous injection can be selected, or the compound anesthetic can be mixed evenly and placed in an aerosol can. Use agent A to enter the induction period, and then use agent B to maintain anesthesia.

[0032] The beneficial effects of the present...

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Abstract

The invention provides an inhalational compound anaesthetic agent. The inhalational compound anaesthetic agent is characterized by comprising an A agent and a B agent, wherein the A agent serves as an inducer and comprises nitrous oxide, sodium chloride, perfume and a compound emulgator; the B agent serves as an anesthesia retaining agent and comprises flos daturae, radix aconiti agrestis, sevoflurane, sodium chloride, perfume and a compound emulgator; according to the A agent, the content of nitrous oxide is 1-5%, the content of the compound emulgator is 15-25%, and the content of the perfume is 0.1-0.3%; according to the B agent, the content of flos daturae is 0.5-0.9g/100mL, the content of radix aconiti agrestis is 0.1-0.5g/100mL, and the content of the sevoflurane is 1.5-2.5%, the content of the compound emulgator is 10-20%, and the content of the perfume is 0.1-0.3%. The inhalational compound anaesthetic agent is simple to operate during use; the A agent can be used for quickly inducing anesthesia and can be directly inhaled by an inhaling device; the B agent is used for retaining anesthesia, can be inhaled by a matched anesthesia machine and can also be infused into the body by other manners; the infusing time and dosage can be flexibly arranged according to the needs of the operation; and the inhalational compound anaesthetic agent can be applied to complex or long-time operation.

Description

technical field [0001] The invention relates to an inhalation anesthetic and its inhalation device. Background technique [0002] Administration of general anesthesia can produce considerable adverse side effects. In general inhalation anesthesia, the anesthesia tube must be placed in the trachea of ​​the human body, and vomiting must be prevented, which often leads to upper respiratory tract injury of the patient. Statistically, many patients experience hoarseness and tenderness in the mouth and throat after surgery. Currently, the doses required for anesthetics to reach target neural organs may have adverse effects on non-target organs, especially the heart, where the risk of cardiopulmonary morbidity is greatly increased during general anesthesia, especially in the elderly, with substantial long-term cognitive impairment following general anesthesia Evidence for (Moller et al., 1988, Lancet., 351:857-861). In addition, overall morbidity and mortality from cardiorespira...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K9/72A61P23/00
Inventor 孟建
Owner 黄玉华
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