Emulsified isoflurane compound anesthetic for dogs and preparation method thereof

A technology of isoflurane and anesthetic, which is applied in the field of intravenous infusion of emulsified isoflurane compound anesthetic for dogs and its preparation, can solve the problems of respiratory and circulatory system influence, complicated anesthesia operation, difficult to apply complex and long-term operation, etc. Rapid and stable induction, quick recovery, flexible and controllable anesthesia maintenance

Inactive Publication Date: 2015-02-04
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problems in the above-mentioned prior art and to develop a dog emulsified isoflurane compound anesthetic in combination with the clinical needs of canine anesthesia. Drugs are scientifically formulated to achieve reasonable compatibility and produce good anesthesia effects, while minimizing the side effects of each single drug, overcoming the complexity of inhalation anesthesia operations, high costs, high technical requirements for equipment, and difficulty in controlling the depth of anesthesia by intramuscular injection and maintenance time, easy to produce obvious respiratory and circulatory system effects, difficult to apply to complex and long-term surgery and other technical problems

Method used

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  • Emulsified isoflurane compound anesthetic for dogs and preparation method thereof
  • Emulsified isoflurane compound anesthetic for dogs and preparation method thereof
  • Emulsified isoflurane compound anesthetic for dogs and preparation method thereof

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Embodiment Construction

[0019] Embodiments of the present invention are described in detail below.

[0020] 1. The emulsified isoflurane compound anesthetic for dogs is composed of isoflurane, fentanyl citrate, lidocaine hydrochloride and 30% fat emulsion, and the content of each component in every 100mL dog emulsified isoflurane compound anesthetic is 8 mL of isoflurane, 20 μg of fentanyl citrate, 48 mg of lidocaine hydrochloride, and 30% fat emulsion as the balance;

[0021] 2. The preparation method of the emulsified isoflurane compound anesthetic for dogs comprises dissolving isoflurane, fentanyl and lidocaine in 30% fat emulsion successively, filling and sealing them in 10 mL ampoule bottles, fully shaking, water bathing, and finally Sterilization prepared the agent.

[0022] The emulsified isoflurane compound anesthetic involved in the present invention is a novel intravenous general anesthesia drug, wherein fentanyl citrate is an opioid receptor agonist and belongs to a powerful narcotic an...

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Abstract

The invention belongs to veterinary medicine preparation technology and provides an emulsified isoflurane compound anesthetic for dogs and a preparation method thereof. The emulsified isoflurane compound anesthetic for the dogs is formed by isoflurane, citric acid fentanyl citrate, lidocaine hydrochloride and 30% of fat emulsion. The isoflurane, the citric acid fentanyl citrate and the lidocaine hydrochloride are dissolved in the 30% of fat emulsion and then potted and sealed in ampoule bottles, after full oscillation, water bath and sterilization, the emulsified isoflurane compound anesthetic for the dogs is obtained. The anesthetic is rapid in anesthesia induction, safe and effective in the process of anesthesia, strong in anesthesia controllability, small in toxic and side effects, convenient to use, and especially suitable for complex operations or long-time operations, and the dogs can revive rapidly.

Description

technical field [0001] The invention belongs to the technical field of preparation of veterinary drugs, and mainly relates to a dog intravenous infusion emulsified isoflurane compound anesthetic and its preparation technology. Background technique [0002] Anesthetics can generally be divided into two types: inhalational anesthetics and intravenous anesthetics. Although the existing inhalation anesthesia has the advantages of strong controllability and little impact on the body, it needs special anesthesia equipment and a dedicated inhalation anesthesia vaporizer when used. Not only the procedures are very cumbersome, but also the equipment and drugs are very expensive. Increase the cost of anesthesia, and it is difficult to popularize and apply it in most domestic animal hospitals. Moreover, due to the large variety of dogs (factors such as body size and upper respiratory tract anatomical characteristics) and the mastery of inhalation anesthesia by veterinary anesthesia per...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4468A61K31/167A61K31/08A61P23/00
Inventor 范宏刚姜胜蔺东启郭凤铭冀伟李大鹏邹晶张建涛刘海玉李雪娇
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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