The invention discloses a novel
benzodiazepine compound as well as a preparation method and application thereof and belongs to the field of
medicinal chemistry; the short-acting
benzodiazepine derivative disclosed by the invention has the characteristics of quick acting, short acting time, strong depth, quick
metabolism, quick awakening and the like. In
anesthesia experiments on mice and rats, theshort-acting
benzodiazepine derivative disclosed by the invention is equivalent to remimazolam in acting time, but the acting time and the waking time are remarkably shortened, the acting depth of part of compounds is obviously enhanced, and the short-acting benzodiazepine derivative has the characteristics of quicker acting speed, shorter acting time, higher acting strength, quicker
metabolism,quicker waking speed and the like; in a long-term infusion
anesthesia experiment on rats, compared with remimazolam, the short-acting benzodiazepine derivative has the advantages that the awakening time and the
recovery time are obviously shortened, and the short-acting benzodiazepine derivative has the characteristics of quicker awakening, quicker
recovery and the like.