Method for preparing triethyl silicane

Abstract

The invention belongs to the field of the preparation of medicinal intermediates, and particularly relates to a method for preparing triethyl silicane. The method comprises the following steps of: performing a condensation reaction of trichlorosilane, halothane and magnesium powder in an alkane or arene organic solvent containing an ether catalyst, and purifying a reaction production to obtain the triethyl silicane. By the method for preparing the triethyl silicane, the obtained product has fewer impurities, and the product content is over 99 percent; and the preparation method has low cost, less pollution and mild reaction condition, is easy and convenient to operate, and is convenient for industrial production.

Description

(1) Technical field

[0001] The invention belongs to the field of preparation of pharmaceutical intermediates, in particular to the preparation of triethylsilane. (2) Background technology

[0002] Triethylsilane is a general-purpose silane-based reducing agent, which is widely used in organic synthesis and is also an important raw material for pharmaceutical intermediates. The current preparation method of triethylsilane is found in GB 795,185 and GB781,533. GB 795,185 describes a synthesis method for preparing triethylsilane by hydrogenation of triethylfluorosilane in the presence of sodium. The reaction temperature of this method reaches 300° C., and the yield reaches 90%. However, this method has high reaction temperature and high price of triethylfluorosilane, which is not suitable for industrial production. GB 781,533 discloses a method for preparing triethylsilane by reacting triethylfluorosilane and diethylaluminumsilane, but the method obtains a mixture of triethyl...