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Traditional Chinese medicine preparation for treating acute organophosphorus poisoning and preparation method thereof

A traditional Chinese medicine preparation and organophosphorus technology are applied in the field of traditional Chinese medicine preparations for treating acute organophosphorus poisoning and their preparation, and achieve the effects of reducing the adverse reaction rate, having no toxic and side effects, and having a simple preparation process.

Inactive Publication Date: 2016-05-25
马成燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a traditional Chinese medicine preparation for treating acute organophosphorus poisoning combined with traditional methods of western medicine, which improves the therapeutic effect and reduces adverse reactions, and its preparation method by using traditional Chinese medicine theory in my country

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0046] When the dosage form of the Chinese medicine preparation is a granule, its preparation method may further comprise the steps:

[0047] Step 1: Mix the raw medicinal materials according to the stated ratio, add ethanol with an alcohol concentration of 85% to 95% relative to the mixture 6 to 10 times, heat to boiling and reflux for 3 to 5 hours, filter, and use percolation to remove Slowly percolate at a speed of 1-2ml per minute, collect the percolation liquid, then concentrate under reduced pressure at a vacuum of 0.06-0.09Mpa to a paste with a relative density of 1.07-1.10 at 50-60°C, spray dry, spray dry The air inlet temperature of the machine is 160-175°C, and the outlet air temperature is 80-85°C, and then crushed into powder to make dry cream powder;

[0048] Step 2: adding 0.2-0.4 times of sucrose powder and 0.1-0.2 times of dextrin to the obtained dry cream powder to make granules, and drying at 50-60°C to obtain granules.

[0049] When the dosage form of descr...

Embodiment 1

[0056] Embodiment 1: the granule prepared by the present invention

[0057] Take 210g Sanxuelian, 150g baby tea, 170g cress, 290g Xiaoxueguangteng, 320g deer jelly, 100g Xuemancao, 170g Jiexue Artemisia, 280g cypress branch, 210g sun needle, 190g Sanxuecao, inch gold 120g of grass, 350g of ambrette, 160g of grass blood, 390g of double ginseng, 210g of Saijingang, 150g of limonium, 260g of bald sore flower, 100g of nosebleed thunder, 360g of sand jujube, 290g of falling sunflower, 170g of bamboo root seven and ground millet root 250g.

[0058] Its preparation method comprises the following steps:

[0059] Step 1: Mix the raw medicinal materials according to the stated ratio, add ethanol with an alcohol concentration 8 times that of the mixture and 90% ethanol, heat to boiling and reflux for 5 hours, filter, and use the percolation method to slowly dissolve at a rate of 1ml per minute. Percolation, collect the percolation liquid, then concentrate under reduced pressure at 0.08...

Embodiment 2

[0061] Embodiment 2: the capsule prepared by the present invention

[0062] Take 240g of blood lotus, 120g of baby tea, 190g of cress, 270g of small blood vine, 350g of deer jelly, 70g of blood grass, 190g of Artemisia japonica, 260g of grass cypress branch, 230g of sun needle, 170g of Sanxue grass, inch gold 150g of grass, 310g of ambrette, 180g of grass blood, 360g of double ginseng, 230g of Saijingang, 120g of limonium, 280g of bald sore flower, 70g of nosebleed thunder, 390g of sand date, 260g of falling sunflower, 190g of bamboo root seven and ground millet root 220g.

[0063] Its preparation method comprises the following steps:

[0064] In the first step, mix blood lotus, baby tea, water celery, chrysanthemum, deer fairy grass and blood mangosaurus according to the stated ratio, add water 5 times that of the mixture to extract the volatile oil, and use the obtained volatile oil with β- Cyclodextrin inclusion compound, the ratio of volatile oil to β-cyclodextrin is 1:4...

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Abstract

The invention provides a traditional Chinese medicine preparation for treating acute organophosphorus poisoning and a preparation method thereof. The traditional Chinese medicine preparation is prepared from Japanese coniogramme rhizomes or herb, catechu, cress, glabrous gardneria stems, dioecious balanophora herb, adnate elder herb, herb of hairy wormwood, finelydivided phtheirospermum roots, oeder plagiopus herb, clarke boea herb, bigflower clinopodium herb, musk mallow, paleaceous knotweed rhizomes, largeflower triplostegia roots, henry hemsleya roots, gmelin sealavender herb, slenderstalk dicranostigma herb, tubeflower dutchmanspipe roots, russianolive fruit, red vinespinach leaves or herb, Chinese tupistra rhizomes and torpedograss roots and rhizomes. The traditional Chinese medicine preparation for treating acute organophosphorus poisoning has the advantages that the traditional Chinese medicine preparation combines a traditional western therapeutic method to treat acute organophosphorus poisoning, the therapeutic effect is better, and toxic and side effects do not exist; meanwhile, the adverse reaction rate and the occurrence rate of serious adverse reactions such as relapse and intermediate syndromes after treatment are decreased, and the preparation technology is simple.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine engineering, in particular to a traditional Chinese medicine preparation for treating acute organophosphorus poisoning and a preparation method thereof. Background technique [0002] There are many kinds of organophosphorus pesticides, which are divided into three categories according to their toxicity: high toxicity, moderate toxicity and low toxicity. Highly toxic organophosphorus pesticides can be poisoned by a small amount of contact, and low-toxic organophosphorus pesticides can also cause harm if they enter the body in large quantities. The time and severity of organophosphorus pesticide poisoning symptoms are closely related to the route of entry, the nature of the pesticide, the amount of entry and absorption, and the health of the human body. Generally, acute poisoning usually occurs within 12 hours. Concentrated or highly toxic organophosphorus pesticides may cause ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P39/02
CPCA61K36/11A61K9/1652A61K9/4866A61K36/10A61K36/185A61K36/23A61K36/264A61K36/282A61K36/35A61K36/42A61K36/48A61K36/56A61K36/66A61K36/704A61K36/80A61K36/86A61K36/896A61K36/899A61K2236/333A61K2236/51A61K2300/00
Inventor 马成燕
Owner 马成燕
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