The invention discloses a new Chinese medicinal composition for treating hepatitis end-stage diseases and a preparation method thereof. The Chinese medicinal composition comprises the following raw materials: dried orange peel, radix curcumae, immature bitter orange, slender dutchmanspipe root, indigowoad leaf, nutgrass galingale rhizome, szechwan chinaberry fruit, combined spicebush root, golden thread, wild chrysanthemum, dandelion, Chinese thorowax root, houttuynia cordata thumb, bezoar, redroot gromwell root, kudzuvine root, raw gypsum, rhizoma anemarrhenae, glabrous greenbrier rhizome, weeping forsythiae capsule, double blossom, mongolian snakegourd root, lightyellow sophora root, rhubarb, Chinese dwarf cherry seed, oriental waterplantain rhizome, longhairy antenoron herb, giant knotweed rhizome, longstamen onion bulb, malt, yanhusuo, peach seed, safflower, leonurus heterophyllus, danshen root and chaff flower root. The Chinese medicinal composition can be prepared into any common oral preparations by a conventional Chinese medicinal preparation method. The Chinese medicinal composition can obviously improve symptoms such as debilitation, appetite reduction, nausea, sickness, hepatauxe and liver damage of people with last-stage hepatitis, and aundice and fever of some patients, can obviously improve symptoms such as gum errhysis, nosebleed, skin ecchymosis, hematochezia, hematemesis, hematuria, purpura occurring in lower limbs and buttocks, bloody pleural effusion or ascites and the like of patients with chronic hepatitis or last-stage fulminant hepatitis, and is characterized by exact clinical effects, obvious treatment effect and quick response. Because medicinal and edible medicaments stipulated by National Formulary are basically adopted for combination, the Chinese medicinal composition has the advantages of low cost, and no toxic or side effect.