57 results about "Gastric injury" patented technology

Methods for treating or preventing gastritis or gastric injury are disclosed, comprising administering a therapeutically effective amount of an amylin or an amylin agonist. Methods are also disclosed for the treatment of pain, fever, inflammation, arthritis, hypercoagulability, or other conditions for which a non-steroidal anti-inflammatory drug would be indicated, comprising administering an amylin or amylin agonist in conjunction with administering a therapeutically effective amount of a non-steroidal anti-inflammatory agent. Pharmaceutical compositions comprising an amylin or amylin agonist and a non-steroidal anti-inflammatory drug are also disclosed.

This invention relates to methods for treating, preventing and / or managing gastric injury, e.g., NSAID-induced gastric injury in a subject including administering to the subject tegaserod, alone or in combination with a proton pump inhibitor. Also provided are compositions and kits for use in methods of the invention.

The invention relates to a gastric lavage model. The gastric lavage model comprises a microprocessor, a transparent model shell connected with a pump line by a pressure sensor and an electric control valve, a stomach model inside the shell, an electromagnetic coil array on the external surface of the stomach model, an air pocket and an electric control valve at a cardiac line, an electric control valve at a pyloric line, the pressure sensor inside a manifold and a low-frequency excitation source. Cardiac closure and intra-abdominal pressure on the stomach are simulated by aerating the air pocket and a hollow chamber of the model shell, pyloric action is simulated by opening of the electric control valve, and gastric peristalsis is simulated by movement of a stomach wall of the model driven by various groups of coils which are excitated. A plurality of gastric parameters during gastric lavage simulation and gastric lavage training can be adjusted and the gastric lavage effect can be observed at real time, thus improving simulation degree of the gastric lavage to avoid or reduce gastric injury caused by actual gastric lavage.

The present invention is directed to nicotinamide, nicotinamide derivatives and prostaglandin mimetics, alone or in combination with an NSAID, and their use in treating pain, inflammation, and / or gastrointestinal toxicty,

The invention discloses a probiotic and an application thereof in the gastric injury, and belongs to the technical field of microorganisms. The Lactobacillus plantarum HFY09 belongs to lactic acid bacteria (LAB), and a preservation number is CGMCC No.16633. A hydrochloric acid / ethanol acute gastric injury model is used to evaluate the preventive effect of the Lactobacillus plantarum HFY09 on the gastric injury. The results show that the HFY09 can inhibit gastric juice secretion, maintains the normal pH value of gastric acid, reduces a gastric mucosal injury area, can inhibit stomach mucosal epithelial cell apoptosis, plays a biological role, and is positively correlated with the concentration. The HFY09 can be used in the production of probiotics or functional foods, and a theoretical basis is provided for the further development and utilization of the HFY09.

Provided is a ganoderma lucidum spore oil with a protective effect on gastric mucosa. The ganoderma lucidum spore oil is obtained by extracting ganoderma lucidum spore powder through a supercritical carbon dioxide double extraction technology, the oleic acid value of the ganoderma lucidum spore oil is smaller than or equal to 2 KOH (mg / g), and the peroxide value is smaller than or equal to 0.1%. Afirst extraction uses a supercritical carbon dioxide extraction technology to extract the ganoderma lucidum spore powder to obtain ganoderma lucidum spore crude oil, and a second extraction uses theganoderma lucidum spore crude oil extracted by the first extraction and then uses the supercritical carbon dioxide extraction technology to purify the ganoderma lucidum spore crude oil to obtain the ganoderma lucidum spore oil. The ganoderma lucidum spore oil has the effect of protecting the gastric mucosa, can significantly reduce gastric mucosal lesion ulcer and bleeding caused by ethanol, inflammatory pain and other gastric mucosal lesion agents, and delays the occurrence time of an ethanol effect. The ganoderma lucidum spore oil is stable in quality, when the ganoderma lucidum spore oil isused as a raw material of food, health-care food or medicine, a product has the effects of protecting the gastric mucosa and preventing and treating gastric mucosa injury, ulcer and bleeding, and supercritical double extraction, purification and separation can be carried out on line.

The invention provides an elecampane soft capsule with an auxiliary protection function for gastric mucosa damage and a preparation method thereof. The invention particularly relates to the preparation method characterized in that the CO2 supercritical extraction technology is adopted in the traditional Chinese medicine elecampane to extract effective ingredients with the auxiliary protection function for the gastric mucosa damage, and extract is dissolved in edible oil to obtain a soft capsule health-care medicine. The technology is easy to operate and is suitable for industrial production. The elecampane soft capsule developed with the method has the advantages of favorable stability and good curative effect and brings good news for patients with the gastric mucosa damage, and the quality of the elecampane soft capsule conforms to the standard.

The invention provides a special medical purpose formula food compound with a digestive tract immunoregulation function and a preparation method thereof, and belongs to the field of special food. Thespecial medical purpose formula food compound is prepared from L-glutamine, oligopeptide, protein peptide, probiotics and stachyose. The preparation method of the compound comprises the following steps of crushing, screening, premixing, blending, inert gas filling, sub-packaging and packaging. The compound and food or special food or a pharmaceutically acceptable carrier or accessory can be made into an oral preparation. The preparation can be powder or tablets or capsules or granules or oral liquid. The compound can be applied for preparing food or special food or medicines which have a protection effect on gastric mucosal lesions and can adjust intestinal flora.

The invention relates to a production method of iron-fortified whey protein milk, and belongs to the technical field of health-care food. With whey protein isolate as a raw material, the whey proteinisolate and ferrous ions are chelated, and through operation of magnetic stirring, centrifugation, ultrafiltration, vacuum freeze drying and the like, whey protein and iron nanoparticles which are small in particle size, good in stability and easy to absorb are produced, and are added into milk to produce the iron-fortified whey protein milk. According to the production method of the iron-fortified whey protein milk, the whey protein isolate and the ferrous ions are used for producing the whey protein and iron nanoparticles so as to produce the iron-fortified whey protein milk, oxidation of fat in the milk can be prevented, organic combination of food and a medicine is achieved, the iron-fortified whey protein milk has a good iron supplement effect, absorption in the intestinal tract of ahuman body can be met, and gastric injuries are reduced. The process route is simple and direct, the equipment investment is little, and the feasibility of industrial popularization is good.

The present invention is directed to nicotinamide derivatives, and their use in treating gastrointestinal disorders.

The invention discloses healthcare baijiu with effect of reducing alcoholic gastric injury and a preparation method of the healthcare baijiu. Dandelion, hericium erinaceus, citron, radix polygonate officinalis, kudzuvine roots and yam are used as raw materials, effective components in the raw materials are extracted and added to ordinary baijiu in a certain proportion, finally, baijiu flavor blending is performed, so that the product has properties of baijiu, can meet the commercial drinking requirement, comprises raw materials which are ordinary food or medicinal and edible food, can meet therequirement of ordinary food to come into the market normally, and provides drinking wine for reducing the alcoholic gastric injury for a consumer.

The invention relates to a composition for treating a gastric ulcer combined gastrointestinal bleeding. The composition comprises the following active components in parts by weight: 8-25 parts of ginsenoside Re, 10-30 parts of ginsenoside Rg3 and 5-20 parts of ginsenoside Rh1. The composition has the effects of obviously improving the gastric mucosal lesion and gastric mucosal lesion, promoting the blood coagulation and stopping bleeding, and is capable of effectively treating and / or preventing gastrointestinal diseases of the gastric ulcer combined gastrointestinal bleeding and the like.

The invention relates to a fermented traditional Chinese medicine for preventing and treating bovine sarcoidosis, and a preparation method thereof. The fermented traditional Chinese medicineis obtained by fermenting various microorganisms and traditional Chinese medicine raw materials, the traditional Chinese medicine raw materials comprise, by weight, 34-55 parts of rhizoma cimicifugae, 55-65 parts of radix puerariae, 15-25 parts of herba schizonepetae, 15-25 parts of radix saposhnikoviae, 25-35 parts of fructus forsythiae, 20-30 parts of fructus arctii, 25-35 parts of flos chrysanthemi indici, 20-30 parts of radix platycodonis, 15-25 parts of apricot kernels, 15-25 parts of fructus aurantii, 15-25 parts of radix arnebiae seu lithospermi, 5-15 parts of periostracum cicada,25-35 parts of herba violae and 25-35 parts of dandelion, and the multiple microorganisms comprise aspergillus oryzae, aspergillus niger, bacillus subtilis, bacillus licheniformis, clostridium butyricum and lactobacillus plantarum. Effective components of traditional Chinese medicines cooperate with one another, the non-specific immune function of an organism is activated, gastric mucosa injury is repaired through various beneficial bacteria, upper cells of gastrointestinal mucosa exert the immune function, pathogens cannot adhere to intestinal walls, and therefore bovine sarcoidosis is effectively prevented and treated.

The invention discloses a beverage formula rich in nutrition, and relates to the filed of health care. The beverage formula comprises the following components in a compounding ratio (in parts by weight): 10-15 parts of Chinese wolfberry fruits, 6-9 parts of rhizoma polygonati, 8-15 parts of black mulberries, 7-11 parts of black sesame seeds, 8-13 parts of Chinese yam, 6-10 parts of lily bulbs, 3-6 parts of chrysanthemums, 5-8 parts of hippophae rhamnoides, 2-5 parts of smoked plums, 12-17 parts of white granulated sugar, 4-7 parts of malic acid and 17-20 parts of drinking water. According to the beverage formula, medicinal and edible foods are adopted, and food therapy is used for replacing medical therapy, so that the efficacies of nourishing the kidney, nourishing the liver, invigorating the spleen, benefiting the lung, nourishing yin, tonifying blood, promoting hair growth, promoting black hair growth, moistening skins, maintaining beauty and delaying aging are achieved, and the beverage formula has the advantages of being simple and convenient to operate, low in cost and easy in mass production; besides, the beverage formula also has the effects of enhancing immunity, assisting in reducing blood lipid, assisting in reducing blood sugar, resisting oxidation, assisting in improving the memory, relieving physical fatigue, assisting in protection on radiation hazards, improving growth and development, and assisting in protection on the damage of gastric mucosa.

The invention discloses a preparation method of a chenopodium quinoa willd extract and application of the chenopodium quinoa willd extract in preparation of medicines and foods for preventing gastric mucosal injury. Experiments prove that the chenopodium quinoa willd extract has the effect of repairing gastric mucosal lesion, and the curative effect is exact.

The invention discloses a low-sugar health-care film-coated interlayer ginger candy that helps repair gastric damage caused by excessive drinking, which comprises the following components in parts by weight: isomalt, ginger, white radish powder, kudzu root powder and wolfberry powder , sweet potato oxidized starch, alcohol enzyme, glutathione, rose hydrosol, Puer tea extract, bamboo vinegar, deep-sea fish oil, gelatinized sweet potato starch, whey protein powder, glycerin, etc. The present invention adopts ginger and white radish powder, kudzu root powder, wolfberry powder, alcohol enzyme, bamboo vinegar, deep-sea fish oil, kudzu flower, etc. to prepare ginger candy, which has rich nutrition and health care effects of repairing gastric damage caused by excessive drinking; during the preparation process Among them, the functional sugar isomalt and citric acid are used to treat ginger slices, which reduces the amount of sugar that can be absorbed by the human body, improves the spicy taste of ginger, and retains the efficacy of ginger. The full utilization of ginger nutrition under the premise of retaining ginger efficacy improves the quality and mouthfeel of the product.

The invention provides a composition with a gastric mucosal lesion protection effect, which is prepared from the following components in parts by weight: 50 to 70 parts of hericium erinaceus extract, 40 to 60 parts of morchella esculenta extract, 30 to 50 parts of rhizoma bletillae extract, 20 to 40 parts of fingered citron extract, 260 to 340 parts of sea buckthron oil and 10 to 30 parts of beewax. Compared with the prior art, according to the theory of traditional Chinese medicine, aiming at the pathogenesis of insufficiency of qi in spleen and stomach and unsmooth qi and blood, the hericium erinaceus extract, the morchella extract, the rhizoma bletillae extract and the fingered citron extract creatively form the traditional Chinese medicine composition, and the hericium erinaceus extract in the formula strengthens the spleen and stomach, is particularly suitable for spleen and stomach meridians and serves as a monarch drug. Toadstool harmonizes stomach, promotes digestion, reduces phlegm and regulates qi; the rhizoma bletillae has the effects of inducing astringency, promoting tissue regeneration, eliminating stagnation and removing stasis, promoting digestion, relieving stasis, promoting tissue regeneration, eliminating rotting, regulating qi and removing stasis, and is used as a ministerial drug together, so that the bleeding volume of gastric mucosa is increased, oxygen supply is promoted, the resistance is enhanced, the blood circulation of the gastric mucosa is smooth, and the qi and blood of a body are smooth. The fingered citron is an adjuvant drug, has the effects of promoting the circulation of qi, tonifying the liver, warming the stomach, tonifying the spleen, arresting vomiting and the like, is soft in nature, does not lack strength, treats the liver and the spleen without hurting the body resistance, is flexible and appropriate in the formula, and plays good assistant and assistant roles.

The invention discloses a traditional Chinese medicine composition for treating digestive tract diseases, pH-responsive in-situ gel and a preparation method of the pH-responsive in-situ gel. The traditional Chinese medicine composition consists of pseudo-ginseng, rhizoma bletillae and dendrobium officinale. The composition and dosage of the traditional Chinese medicine compound are screened and determined through animal experiments; the characteristic that low-acetyl gellan gum and sodium alginate can be subjected to phase change to form gel under gastric acid pH is found through screening, the pH-responsive in-situ gel is prepared from the low-acetyl gellan gum and the sodium alginate and the traditional Chinese medicine composition, gastric emptying of active ingredients of the traditional Chinese medicine composition can be delayed, the action time of the medicine in the stomach can be prolonged, and experimental results show that: the pH-responsive in-situ gel can significantly improve gastric mucosa lesion caused by ethanol, and shows a good gastric mucosa protection effect in the aspects of gastric tissue morphology, histopathologic slices, gastric ulcer index and inhibition rate, and gastric mucosa protection related biochemical indexes (SOD, VEGF-A and EGF).

The invention discloses application of andrographolide, and belongs to the field of medicine application. The medicine is used to protect gastric mucosa, is capable of mitigating gastric mucosal injury caused by drinking, helicobacter pylori and abnormal gastric acid secretion, is suitable for long-term administration, and has no obvious side effect.

The invention relates to the technical field of medicines and in particular relates to a composition as well as a preparation method and application thereof. The composition is prepared from herba polygoni salicifolii and folium et ramulus evodiae, wherein the herba polygoni salicifolii is a sovereign drug and the folium et ramulus evodiae is an assistant and guide drug. The two drugs are reasonably matched to realize the effects of clearing away heat and dispelling dampness, and promoting blood circulation and stopping pain. A pharmacodynamic research shows that the composition has a remarkable protection effect on gastric mucosal injuries and can be used for effectively improving the cell survival rate of H2O2 or ethanol caused cell injuries, promoting the multiplication of normal GES-1cells, improving the expression of an important transcription factor Nrf2 capable of adjusting cell anti-oxidization stress, inducing the expression of downstream haem oxygenase-1 (HO-1) and eliminating surplus oxygen free radicals, so that the anti-oxidization capability of gastric mucosa is enhanced; the composition can be used for preparing a medicine for preventing and / or treating the gastricmucosal injuries.

The invention discloses a composition with an auxiliary protection function on gastric mucosal lesion and application of the composition, and belongs to the technical field of health care products. According to the composition disclosed by the invention, the hericium erinaceus extract, the broccoli seed extract, the turmeric extract and the radix aucklandiae extract are compounded and matched, so that compared with existing commercially available products or similar compositions, the composition disclosed by the invention has a remarkable synergistic gastric mucosal lesion protection effect; animal model experiments and human body trial feeding experiments prove the efficacy of the product. The product is mild and stable in property, does not obviously stimulate the stomach after being used, and can be effectively applied to preparation of medicinal and edible products. The invention also provides application of the composition in preparation of a product with an auxiliary protection function on gastric mucosal lesion.

The invention relates to an FFA4 (GPR120) receptor agonist and an application thereof. Particularly the invention relates to a discovery of an effect target from a natural plant naphthoquinone compound, wherein the target point is a G protein coupled receptor GPR120, and the GPR120 receptor agonist is acetylshikonin, lapachol, alkannin, and / or corresponding pharmaceutically acceptable salts, solvates, polymorphs and pharmaceutical compositions of acetylshikonin, lapachol and alkannin. In-vitro cell target experiments show that acetylshikonin, lapachol and alkannin are agonists of GPR120. In vitro cell experiment tests show that a boraginaceae plate extract which is subjected to cold leaching by 95% ethanol also has GPR120 agonistic activity. Studies show that GPR120 receptors are associated with non-steroidal anti-inflammatory drug-induced gastric injury, bone stuffiness, Crohn's diseases and other diseases, and therefore the agonists have potential pharmaceutical uses.

The invention discloses a composition for protecting a gastric mucosa and a healthcare product and relates to the technical field of healthcare foods. The composition comprises stachyose, glutamine, probiotics and yeast zinc. The composition disclosed by the invention is further made into powder, granules, tablets and capsules which are convenient to take, acute gastric mucosa damage caused by alcohol can be remarkably relieved after the composition disclosed by the invention is taken, the treatment rate of chronic superficial gastritis can be up to about 70% 30 days after the composition disclosed by the invention is taken, and in addition, no side effect can be caused.

The invention relates to the technical field of medicinal chemistry, and particularly discloses a composition and application thereof in preparation of a medicine for treating gastric injury and / or gastric ulcer. The composition comprises a traditional Chinese medicine extract and an animal liver extract. The traditional Chinese medicine extract is a poria cocos extract. The poria cocos extract is prepared by the following steps: S11, extracting a traditional Chinese medicine poria cocos with an organic solvent, and concentrating and drying an extracting solution to obtain a poria cocos organic solvent extract; s12, loading the poria cocos organic solvent extract on a silica gel column, and eluting with ethyl acetate to obtain ethyl acetate eluent; eluting with ethyl acetate, and then eluting with ethanol to obtain an ethanol eluent; and concentrating and drying the ethanol eluent to obtain the poria cocos extract. Researches show that the composition has excellent effects of treating gastric ulcer and stomach injury; therefore, the compound can be used as an effective component for developing medicines for treating gastric ulcer and gastric injury.

The invention provides gastric mucosa wound surface protection glue with thixotropy and acid sensitivity and an application of the gastric mucosa wound surface protection glue, and belongs to the field of biological medicine preparations. The gastric mucosa wound surface protection glue with thixotropy comprises the following effective components: a tackifier, an acid-sensitive gelling substance, a thixotropic agent, a plasticizer, a retarder and a pH value regulator, wherein the pH value of the gastric injury mucosa wound surface protection glue is greater than or equal to 7. Curing liquid can also be contained and is used for curing the protection glue at a specified position. The protection glue can form a colloidal film on the surface of ulcer to promote healing of the ulcer. In addition, the product has thixotropy and is kept in a non-flowing state on the wound surface within a short time, then the protection glue is rapidly fixed to the surface of the damaged mucosa through the curing liquid, and the flowing problem of the protection glue is solved. Animal experiments show that the gastric mucosa wound surface protection glue can obviously promote the repair of injured gastric mucosa, so that the gastric mucosa wound surface protection glue has the effects of promoting healing and protecting gastric mucosa injury.

The invention discloses a research method of an action mechanism for promoting gastric mucosa repairing to treat gastric ulcer through JNK / SAPK and ERK signal channels. The research method comprises the following steps: 1, preparation of chaihu shugan powder; 2, establishing of a liver-depression syndrome and glacial acetic acid gastric ulcer combined model; 3, detection of expression of p38MAPK and ERK proteins through an immunohistochemical method; and 4, detection of expression of the p38MAPK and ERK proteins through a Western blot method. The influence of a liver soothing and depression relieving method on JNK / SAPK and ERK of gastric mucosa of gastric ulcer mice with a liver-depression syndrome is observed, an internal mechanism for treating gastric ulcer through the liver soothing anddepression relieving method is illuminated from molecular biology, the influence of the liver soothing and depression relieving method on gastric mucosa damage repairing of the gastric ulcer mice with the liver-depression syndrome and the action mechanism of curative effects of the liver soothing and depression relieving method are explored, and thus the experimental basis is laid for developmentof traditional Chinese medicine and new medicine for treating gastric ulcer.

The invention discloses a composition for repairing gastric mucosa and improving gastric motility and a preparation method of the composition. The composition comprises the following components in percentage by mass: 12.77-45.45% of gymnadenia conopsea, 18.00-50.00% of goldthread root, 6.12-32.26% of endothelium corneum gigeriae galli, 6.12-32.26% of bergamot and 5.66-22.22% of fennel, wherein the sum of the mass percentage of the above components is 100%. The preparation method comprises the following steps: extracting the raw materials, concentrating, drying, crushing, sterilizing, encapsulating and the like to prepare the composition. The composition is a health-care medicine which is green, natural, safe, non-toxic and reliable in curative effect, and has the effects of removing slough, promoting tissue regeneration, invigorating stomach, helping digestion, dispelling cold and relieving pain. The composition has an exact treatment effect on gastric mucosal lesion and gastropathy caused by insufficient gastric motility by promoting repair and regeneration of gastric mucosal ulcer eroded parts, eliminating inflammation and pain, enhancing gastric motility and digestive function and the like, and can be used for preventing and treating gastropathy.

The invention relates to application of Zizhu Darcy in inhibition of gastric mucosa inflammation caused by helicobacter pylori infection, and belongs to the technical field of biological medicine. Animal in-vivo experiments prove that the Zhuzudaxi can reverse gastric mucosal lesion caused by helicobacter pylori infection to a certain extent and relieve gastric mucosal inflammation caused by helicobacter pylori infection. Therefore, the Zhuzhu Darcy has important clinical application value in the aspect of inhibiting inflammation caused by helicobacter pylori infection.