Composition as well as preparation method and application thereof

A composition and drug technology, applied in the field of medicine, to achieve the effects of good therapeutic effect, high safety and broad market prospects

Inactive Publication Date: 2018-12-11
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no relevant reports about the use of Polygonum-Sanchaku extract in the treatment of anti-oxidative stress injury and gastric mucosal injury.

Method used

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  • Composition as well as preparation method and application thereof
  • Composition as well as preparation method and application thereof
  • Composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 Composition of the present invention

[0040] Prepared from the following components by weight:

[0041] Polygonum 10g, Sanchaku 15g.

[0042] Preparation method: take Polygonum capericum and trigeminus, mix well, pulverize, add 10 times the amount of 60% ethanol, soak for 0.5 hours, heat and reflux for 1 hour, filter, add 8 times the amount of 60% ethanol to the filter residue, heat and reflux for 1 hour, and combine the extracts , filtered, and the filtrate was concentrated under reduced pressure and freeze-dried to obtain dry powder of the extract. Take 1 part of the extract dry powder, dissolve it with 60% ethanol, put it on AB-8 macroporous adsorption resin, elute it with distilled water first, then elute it with 60% ethanol, collect the alcohol eluate, concentrate and dry under reduced pressure, and obtain the present invention combination.

Embodiment 2

[0043] Embodiment 2 compositions of the present invention

[0044] Prepared from the following components by weight:

[0045] Polygonum 12g, Sanchaku 18g.

[0046] Preparation method: take Polygonum capericum and trigeminus, mix well, crush, add 10 times the amount of 50% ethanol, soak for 0.5 hours, heat and reflux for 1 hour, filter, add 8 times the amount of 50% ethanol to the filter residue, heat and reflux for 1 hour, and combine the extracts , filtered, and the filtrate was concentrated under reduced pressure and freeze-dried to obtain dry powder of the extract. Take 1 part of dry extract powder, dissolve it with 50% ethanol, put it on D101 macroporous adsorption resin, elute it first with distilled water, then with 50% ethanol, collect the alcohol eluate, concentrate and dry under reduced pressure, and obtain the composition of the present invention .

Embodiment 3

[0047] Embodiment 3 compositions of the present invention

[0048] Prepared from the following components by weight:

[0049] Hot Polygonum 15g, Sanchaku 20g.

[0050] Preparation method: take Polygonum capericum and trigeminus, mix well, crush, add 10 times the amount of 80% ethanol, soak for 0.5 hours, heat and reflux for 1 hour, filter, add 8 times the amount of 80% ethanol to the filter residue, heat and reflux for 1 hour, and combine the extracts , filtered, and the filtrate was concentrated under reduced pressure and freeze-dried to obtain dry powder of the extract. Take 1 part of the extract dry powder, dissolve it with 80% ethanol, put it on WLD-3 macroporous adsorption resin, elute it with distilled water first, then elute it with 80% ethanol, collect the alcohol eluate, concentrate and dry under reduced pressure, and obtain the present invention combination.

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Abstract

The invention relates to the technical field of medicines and in particular relates to a composition as well as a preparation method and application thereof. The composition is prepared from herba polygoni salicifolii and folium et ramulus evodiae, wherein the herba polygoni salicifolii is a sovereign drug and the folium et ramulus evodiae is an assistant and guide drug. The two drugs are reasonably matched to realize the effects of clearing away heat and dispelling dampness, and promoting blood circulation and stopping pain. A pharmacodynamic research shows that the composition has a remarkable protection effect on gastric mucosal injuries and can be used for effectively improving the cell survival rate of H2O2 or ethanol caused cell injuries, promoting the multiplication of normal GES-1cells, improving the expression of an important transcription factor Nrf2 capable of adjusting cell anti-oxidization stress, inducing the expression of downstream haem oxygenase-1 (HO-1) and eliminating surplus oxygen free radicals, so that the anti-oxidization capability of gastric mucosa is enhanced; the composition can be used for preparing a medicine for preventing and / or treating the gastricmucosal injuries.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition with a protective effect on gastric mucosal damage, a preparation method and application thereof. Background technique [0002] Gastric mucosal injury-related diseases are common digestive system diseases that are stimulated by harmful factors such as stress, physical chemistry, biology, and drugs, and are characterized by gastric mucosal erosion, bleeding, or superficial ulcers. Acute gastric mucosal lesions, chronic gastritis, peptic ulcer, gastric mucosal prolapse and other diseases. Acute gastric mucosal lesion is a common and frequently-occurring disease, and it is one of the most common serious clinical complications, especially prone to severe burns, major surgery, severe craniocerebral injury, severe infection, etc. Gastrointestinal bleeding is the most common cause of upper gastrointestinal bleeding, accounting for about 20-30%. [0003] With the acceler...

Claims

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Application Information

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IPC IPC(8): A61K36/754A61P1/04
CPCA61K36/704A61K36/754A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P1/04A61K2300/00
Inventor 任守忠马志健王辉林开文陈君
Owner HAINAN MEDICAL COLLEGE
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