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Application of Zhuzhu Darcy in inhibition of gastric mucosa inflammation caused by helicobacter pylori infection

A technology based on Helicobacter pylori and Zondacil, applied in the field of biomedicine, can solve the problems of gastric mucosal inflammation and its unclear mechanism, and achieve the effect of reducing gastric mucosal inflammation.

Inactive Publication Date: 2022-03-15
西藏甘露藏药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the gastric mucosal inflammation caused by Zuzudaxi against Helicobacter pylori infection and its mechanism are unclear

Method used

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  • Application of Zhuzhu Darcy in inhibition of gastric mucosa inflammation caused by helicobacter pylori infection
  • Application of Zhuzhu Darcy in inhibition of gastric mucosa inflammation caused by helicobacter pylori infection
  • Application of Zhuzhu Darcy in inhibition of gastric mucosa inflammation caused by helicobacter pylori infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment one pre-test

[0035] 1. Test material

[0036] (1) Test subjects: 36 SPF grade C57BL / 6 mice, male, 6 weeks old, production license number SCXK (Beijing) 2017-0005, provided by the China Food and Drug Control Institute (Daxing) Animal Resource Center. Animal experiment environment such as figure 1 As indicated, a constant temperature and humidity SPF (Specific Pathogen Free) level animal laboratory is used. The mice were raised in CP-3 mouse cages, the litter was corn cob litter, fed with SPF rat maintenance feed, and drank experimental animal drinking water ( figure 2 A).

[0037] Table 1 Animal weight information table

[0038] Purchase animal weight and age Animal body weight and age at the time of administration 16g~20g (about 6 weeks old) 27g~32g (about 12 weeks old)

[0039] (2) Strain: the international standard Helicobacter pylori (Hp) SS1 strain stored in the laboratory of Peking University Third Hospital.

[0040] (3) T...

Embodiment 2

[0083] Embodiment two formal test

[0084] 1. Test material

[0085] (1) Test subjects: 30 SPF grade C57BL / 6 mice, male, 6 weeks old, production license number SCXK (Beijing) 2017-0005, provided by the Animal Resource Center of China National Institutes for Food and Drug Control (Daxing). The animal experiment environment and feeding conditions are the same as in Example 1.

[0086] Table 5 Animal weight information table

[0087] Purchase animal weight and age Animal body weight and age at the time of administration 16g~20g (about 6 weeks old) 35g~40g (about 19 weeks old)

[0088] (2) bacterial classification: with embodiment one.

[0089] (3) Test product and solvent: Zuzhudasi finished pill (1g / pill), the dosage of Zuzhudasi is 0.083g / kg, 0.166g / kg, and the treatment cycle and solvent are the same as in Example 1.

[0090] Table 6 Test product preparation information table

[0091] Dosage Weigh (g) Preparation volume (mL) Concentr...

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Abstract

The invention relates to application of Zizhu Darcy in inhibition of gastric mucosa inflammation caused by helicobacter pylori infection, and belongs to the technical field of biological medicine. Animal in-vivo experiments prove that the Zhuzudaxi can reverse gastric mucosal lesion caused by helicobacter pylori infection to a certain extent and relieve gastric mucosal inflammation caused by helicobacter pylori infection. Therefore, the Zhuzhu Darcy has important clinical application value in the aspect of inhibiting inflammation caused by helicobacter pylori infection.

Description

technical field [0001] The invention relates to the technical field of biomedicine, and in particular to the application of succulent darcy in inhibiting gastric mucosal inflammation caused by Helicobacter pylori infection. Background technique [0002] Helicobacter pylori (Hp) is a Gram-negative bacterium that lives in the gastric mucosa. It is a common pathogen in chronic digestive system diseases. patient health and life. Helicobacter pylori is closely related to peptic ulcer, digestive system tumors, and gastrointestinal mucosa-associated lymphoid tissue lymphoma, and is listed as a class I carcinogen of gastric cancer by the World Health Organization. In my country, the average infection rate of Hp is about 58.07%. [0003] With the development of Chinese medicine in my country, Chinese medicine researchers have found that the use of Chinese medicine can effectively treat Helicobacter pylori. Clinical studies of Tibetan medicine have shown that Tibetan medicine can t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P1/04A61P31/04A61P29/00A61K33/06A61K33/10A61K35/413A61K35/55
CPCA61K33/06A61K36/285A61K36/61A61K36/714A61K36/88A61K36/185A61K36/9064A61K35/413A61K36/56A61K35/55A61K33/10A61P1/04A61P31/04A61P29/00A61K2300/00
Inventor 石岩岩格桑罗布丁士刚詹思延李渊李默李楠宁静周凤白玛洛桑顿珠尼玛曲珍洛桑次仁
Owner 西藏甘露藏药股份有限公司
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