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Lauroyl arginine ethyl ester derivative and application thereof as animal antibacterial agent
ActiveCN108976151AGood antibacterial effectDelay drug resistanceAntibacterial agentsOrganic active ingredientsEscherichia coliSide effect
The invention relates to a novel veterinary antibacterial agent and in particular relates to a lauroyl arginine ethyl ester ion pair compound derivative which is prepared from lauroyl arginine ethyl ester LAE and an organic acid through reactions. As a livestock aquatic animal antibacterial agent, the derivative is capable of preventing and treating duckling riemerella anatipestifer diseases caused by riemerella anatipestifer, is capable of treating peritonitis diseases caused by escherichia coli and staphylococcus aureus, is capable of preventing and treating fish septicemia caused by aeromonas sobria, and has remarkably improved prevention and treatment effects when being compared with a conventional LAE veterinary antibacterial agent. The derivative can be completely degraded in human bodies and animal bodies and is small in toxic and side effect, environment drug resistance bacteria caused by residual antibacterial agents discharged into the environment can be avoided, and small adverse environment influence can be caused while an effective antibacterial effect is achieved.
Owner:EAST CHINA NORMAL UNIV
Protein feed rich in small peptides and multi-enzyme bacteria and preparation method thereof
InactiveCN101642187AReduce excess residueEnhance physical fitnessFood processingAnimal feeding stuffBiotechnologyFood borne
The invention relates to protein feed rich in small peptides and multi-enzyme strains and a preparation method thereof. The protein feed is prepared by fermenting soybean meal, cottonseed meal, rapeseed meal, bone meal, wheat bran, common salt, light calcium carbonate, water and strains in a fermentation bin. The preparation method of the protein feed comprises the following steps: mixing the soybean meal, the cottonseed meal, the rapeseed meal, the bone meal, the wheat bran, the common salt and the light calcium carbonate in percentage by weight; adding 20-30 percent of water; sending the mixture to an air steamer; adding high-pressure steam to the air steamer so as to increase the air pressure to 1-2 MPa and the temperature to 140-200 DEG C; keeping the pressure for 4-6 minutes; momentarily releasing the mixture in the air steamer; sending the mixture to the fermentation bin; inoculating 3-5 percent of strains when the temperature of the mixture falls to 30-37 DEG C; fermenting for 72 hours at the temperature of 32-37 DEG C; discharging from the bin; and bagging to obtain a finished product. The product has strong disease-resistant function and low cost, increases the productionof animal by-products by more than 20 percent, is nontoxic, harmless and pollution-free and can inhibit food-borne diseases represented in cancers and subhealth phenomena from spreading.
Owner:张培举
Application of DNA (Deoxyribonucleic Acid) tetrahedron to preparation of medicament for treating Alzheimer's disease
ActiveCN109806274AKeep alivePromote proliferationOrganic active ingredientsNervous disorderDiseaseApoptosis
Owner:成都腾达树纳米生物科技有限公司
NAC from wheat for increasing grain protein content
ActiveUS7820882B2Increase rate increaseIncrease mRNA levelsBryophytesSugar derivativesGMO PlantsSenescence function
The present invention provides wheat NAC nucleic acids and proteins that modulate grain protein content and senescence in plants. Overexpression of a NAC coding sequence can accelerate senescence and increase grain protein content and inhibition of expression can delay senescence. The invention also provides methods of using the nucleic acids to produce transgenic plants with altered grain protein content or senescence.
Owner:CARMEL HAIFA UNIV ECONOMIC +1
Special high-efficiency feed for mutton sheep
InactiveCN104413290AIncrease protein levelsImprove palatabilityAnimal feeding stuffDiseaseFeed conversion ratio
The invention relates to a special high-efficiency feed for mutton sheep. The feed consists of the following ingredients in parts by weight: 20-30 parts of brans, 15-20 parts of rice brans, 5-15 parts of soybean meal, 10-30 parts of cottonseed meal, 5-20 parts of corn meal, 1-5 parts of a mutton sheep premix compound, 1-5 parts of calcium hydrophosphate, 1-4 parts of salt, 10-20 parts of an immunity-enhanced plant and 5-7 parts of a freeze-dried powder additive. The soybean meal in the ingredients of the feed is a main protein raw material for preparing feeds for livestock and poultry, is rich in high protein and is combined with the cottonseed meal, the corn meal, the mutton sheep premix compound, the calcium hydrophosphate and the salt so that the feed is high in protein level, good in palatability and capable of obviously increasing the growth rate of the mutton sheep and increasing the feed conversion ratio; meanwhile, due to the immunity-enhanced plant, the use of drugs is reduced, so that drug residues and drug resistance are reduced, the production cost is lowered, the weight increment speed is increased, the disease resistance is improved, and the feed can be used as a special high-efficiency feed for the mutton sheep so as to produce pollution-free healthy sheep meat.
Owner:TIANJIN RIXING LIVESTOCK & POULTRY CULTURE PROFESSIONAL COOP
Novel application of echinatin
ActiveCN105232501AIncrease protein levelsHepatic necrosis area decreasedOrganic active ingredientsCosmetic preparationsMedicineMetabolic enzymes
The invention discloses novel application of echinatin. The echinatin and at least one of medically acceptable salt, ester, solvate, stereoisomer, tautomer and prodrug of the echinatin are applied to the product which has at least one of the following functions: (1) activating the signal path of Nrf2 and / or AMPK; (2) strengthening the expression of Nrf2, antioxidase and / or metabolic enzymes; (3) resisting aging; (4) inhibiting cell injury and tissue injury caused by oxidation; (5) protecting liver injury; (6) protecting chemical liver injury or oxidative liver injury; and (7) resisting vicious transformation of skin cells. The echinatin can be separated and purified from licorice root. The novel application of the echinatin provides a novel thought to researches and development of echinatin, and a series of novel products with the application are further provided.
Owner:PEKING UNIV
Efficient production method for cellulase
PendingCN105255848ABest carbon to nitrogen ratioPrevent autophagyGlycosylasesPenicillium bilaiaeBiotechnology
The invention relates to an efficient production method for cellulase, and particularly discloses a method for controlling cellulase fermentation through the oxygen uptake rate. Through optimal screening of culture media and optimal controlling over oxygen uptake rate conditions, the stable fermentation method is determined, and the enzyme activity of a produced cellulase preparation is improved by more than 50 percent; the technology can be widely applied to cellulase production through filamentous fungi such as penicillium and aspergillus.
Owner:SHANDONG LONGLIVE BIO TECH CO LTD
Application of SET gene in preparing product for diagnosing and/or treating gastric cancer
InactiveCN106521022AIncrease protein levelsInhibit migrationMicrobiological testing/measurementBiological material analysisAkt signallingGastric carcinoma
The invention belongs to the fields of biotechnology and medicine, and in particular relates to an application of an SET gene in preparing a product for diagnosing and / or treating gastric cancer. It is provided that the SET achieves frequent high expression (80%) in gastric cancer tissues, and the increase in SET expression is significantly correlated to aggressive phenotype and worse prognosis of a patient with the gastric cancer (P is less than 0.05). The low expression of the SET can obviously inhibit the migration and the invasion of gastric cancer cells. In addition, the SET, by virtue of a PP2A / Akt signaling pathway, can promote tumor malignant transformation. Furthermore, the gastric cancer tissues are obviously higher than para-carcinoma tissues in SET protein level. Therefore, the SET gene can serve as a specific marker gene for diagnosing the gastric cancer, so that it is more accurate and rapid to diagnose the gastric cancer. The SET gene provided by the invention provides a novel therapeutic target for the prevention and the treatment of the gastric cancer.
Owner:HUBEI UNIVERSITY OF MEDICINE
Compound feed capable of enhancing immunity, special for lactation sows
InactiveCN107873983ATo promote metabolismImprove immunityFood processingAnimal feeding stuffAnimal scienceProtein FADD
The invention discloses a compound feed capable of enhancing immunity, special for lactation sows. The compound feed comprises the following raw materials in parts by weight: 30-40 parts of soybean flour, 30-50 parts of tangor peel, 4-8 parts of chlorella, 25-35 parts of common ducksmeat herbs, 60-65 parts of a protein additive, 0.02-0.04 part of bifidobacteria, 3-5 parts of an immunopotentiatingagent, 2-4 parts of malt sugar, 2-4 parts of vermiculite powder and 4-8 parts of gordon euryale seed powder, wherein the protein additive comprises the following components in parts by weight of 20-30parts of fermented tea seed meal, 10-18 parts of coconut meal, 10-16 parts of fly larva powder, 4-8 parts of whey protein and 3-7 parts of locust powder, and the immunopotentiating agent comprises the following components in parts by weight of 2-4 parts of a Chinese herbal medicine additive, 0.3-0.5 part of chitosan, 0.2-0.4 part of tryptophan calcium and 0.2-0.4 part of selenium-enriched yeast.
Owner:全椒县王震家禽养殖专业合作社
Special feed for mutton sheep
InactiveCN104413294AIncrease protein levelsGood palatabilityAnimal feeding stuffFreeze dryDrug resistance
The invention relates to a special feed for mutton sheep. The special feed consists of the following ingredients in parts by weight: 5-15 parts of soybean meal, 10-30 parts of cottonseed meal, 5-20 parts of corn meal, 1-5 parts of a mutton sheep premix compound, 1-5 parts of calcium hydrophosphate, 1-4 parts of salt, 10-20 parts of an immunity-enhanced plant and 5-7 parts of a freeze-dried powder additive. In the ingredients of the feed disclosed by the invention, the soybean meal is a main protein raw material for preparing livestock and poultry, is rich in high protein and is combined with the cottonseed meal, the corn meal, the mutton sheep premix compound, the calcium hydrophosphate and the salt so that the feed is high in protein level, good in palatability and capable of obviously increasing the growth rate of the mutton sheep and increasing the feed conversion ratio; meanwhile, due to the immunity-enhanced plant, the use of drugs is reduced, so that drug residues and drug resistance are reduced, the production cost is lowered, the weight increment speed is increased, the disease resistance is improved, and the feed can be used as a special feed for the mutton sheep so as to produce pollution-free healthy sheep meat.
Owner:TIANJIN WEIDA LIVESTOCK & POULTRY CULTURE CO LTD
Breeder egg brooding and each-stage feeding method of spotted-brown chickens with week age of 50-59 weeks
InactiveCN105981688AIncrease protein levelsLittle impact on growth performanceAnimal feeding stuffIntermediate stageFeeding Methods
The invention relates to a breeder egg brooding and each-stage feeding method of spotted-brown chickens with week age of 50-59 weeks, belongs to the technical field of poultry culture and particularly relates to a brooding and feeding method of Huainan spotted-brown chickens. The scheme is as follows: the brooding of the spotted-brown chickens comprises a brooding early stage, a brooding middle stage and a brooding later stage; in the brooding early stage, chickens with the age of 1-14 days are cultured; in the brooding middle stage, the spotted-brown chickens with the age of 15-28 days are cultured; in the brooding later stage, the spotted-brown chickens with the age of 29-42 days are cultured. According to the method, a brooding environment condition is easy to control, heat energy is saved and disinfection is convenient to realize; padding and feeding cost are saved and the chickens are convenient to observe so that production management is easy to carry out; the survival rate of the spotted-brown chickens and the production benefits are improved.
Owner:安徽皖西麻黄鸡禽业原种有限公司
Application of polygala saponin in preparation of drugs for preventing or treating Parkinson's disease
ActiveCN102274296AProtectiveHas a protective therapeutic effectNervous disorderPlant ingredientsLactate dehydrogenaseTherapeutic effect
The invention discloses an application of tenuigenin in preparing a medicament for preventing or treating a PD and improving the movement coordination capability. Tenuigenin has a certain protection effect on cells and animal models of the PD, and allows the lactate dehydrogenase content to be reduced and the protein level of a rate-limiting enzyme tyrosine decarboxylase TH metabolized by dopamine to be increased by obviously increasing the cell vitality of dopaminergic neurons to make the number of positive cells of the TH in a nigral locus obviously increase. Tenuigenin has an obvious protection and treatment effect on the cells and the animal models of the PD.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Human leukocyte protease inhibitory factor as well as recombinant preparation and application thereof
ActiveCN110964094ALose weightInhibit fatty degenerationPeptide/protein ingredientsMetabolism disorderDiseaseWhite blood cell
The invention relates to a human leukocyte protease inhibitory factor as well as recombinant preparation and an application thereof, which belong to the field of biological medicines. The amino acid sequence contained in the human leukocyte protease inhibitory inhibitor is as follows: (1) an amino acid sequence shown in SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3; (2) an amino acid sequence obtained by connecting a label to the N end or / and C end of the amino acid sequence shown in SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3; and (3) an amino acid sequence which is obtained by substituting, deleting or adding one or more amino acids to the amino acid sequence shown in SEQ ID NO: 1 and SEQ ID NO: 2 or SEQ ID NO: 3 and has the activity of the human leukocyte protease inhibitory factor. The preparation method comprises the following steps: constructing plasmids, carrying out inducible expression to obtain fusion protein, purifying, and carrying out renaturation concentration. The protein provided by the invention has important application in preparation of drugs for treating metabolic diseases, and can reduce weight, inhibit increase of adipose tissue weight and inhibit liver fatty degeneration.
Owner:HUAZHONG UNIV OF SCI & TECH
Antibody binding specifically to CD66c and use thereof
ActiveUS11220543B2Efficient detectionMaximize the effectBiological material analysisImmunoglobulins against cell receptors/antigens/surface-determinantsDiseaseAntigen Binding Fragment
The present invention relates to an anti-CD66c antibody and its use for treating cancer, and more particularly, it is possible to induce T-cell activation or humoral immune response using an antibody specifically recognizing CD66c. A nucleic acid molecule encoding the antibody or antigen-binding fragment thereof, a vector comprising the nucleic acid molecule, a host cell and the antibody or antigen-binding fragment thereof is used for alleviation, prevention, treatment or diagnosis of CD66c-related disease.
Owner:KUMHO HT
Methods for the treatment of alzheimers disease and compositions therefore
InactiveUS20060135412A1Suitable for treatmentIncrease mRNA levelsOrganic active ingredientsNervous disorderSecretionInhibitory effect
The invention discloses previously unknown modifiers of Aβ secretion. These proteins are identified as suitable targets for the development of new therapeutics to treat, prevent or ameliorate pathological conditions associated with Aβ secretion, including Alzheimer's Disease. The invention also relates to methods to treat, prevent or ameliorate said pathological conditions and pharmaceutical compositions therefore comprising modulators with inhibitory effects on the activity and / or expression of these modifiers.
Owner:COHEN DALIA +1
RBP2 enzyme inhibitor small molecular compound WXSA-072A as well as preparation method and anti-gastric cancer application thereof
InactiveCN109438339AReduced ability to migrateIncrease protein levelsOrganic active ingredientsOrganic chemistryCancer drugsReactive site
The invention provides a RBP2 enzyme activity inhibition small molecular compound WXSA-072A designed and synthesized for enzyme active sites, and provides a preparation method thereof. The experimentproves that the compound can significantly increase an H3K4me3 protein level in gastric cancer cells BGC-823 of a human, has an obvious function of inhibiting the RBP2 enzyme activity, and can reducea metastasizing ability of the gastric cancer cells BGC-823 of the human. According to the invention, the RBP2 enzyme inhibitor small molecular compound can be used for preparing anti-gastric cancer drugs as a gastric cancer inhibitor. The formula is shown in the specification.
Owner:SHANDONG UNIV
Alcohol extract of rhytidium rugosum, its preparation method and application in preparation of anti-liver cancer drugs
ActiveCN112156117ALower membrane potentialImprove immunityDigestive systemBryophyta medical ingredientsCancer cellMitochondrial pathway
The invention provides an alcohol extract of rhytidium rugosum, its preparation method and application in preparation of anti-liver caner drugs, and belongs to the field of medicines. According to thepreparation method of the alcohol extract of rhytidium rugosum, the alcohol extract of rhytidium rugosum is obtained by extracting rhytidium rugosum with absolute ethyl alcohol. Results of embodiments show that the obtained alcohol extract of rhytidium rugosum inhibits the growth of liver cancer cells in a dose-dependent manner, and has no toxic effect on mouse spleen cells. The alcohol extract of rhytidium rugosum activates the caspase signal pathway through a mitochondrial pathway and a death receptor pathway to induce apoptosis of liver cancer cells. The alcohol extract of rhytidium rugosum can also significantly increase the spleen index and the number of immune cells in mice, so as to improve the body immunity and further improve the anti-tumor effect. The prepared alcohol extract ofrhytidium rugosum has a remarkable anti-tumor effect, contains pure natural components, is safe and non-toxic, and lays a foundation for research and development of novel anti-liver cancer drugs.
Owner:XINJIANG QIANJIN RONGYAO INVESTMENT CO LTD
Application of tenuigenin in preparing medicament for preventing or treating parkinson' disease (PD)
ActiveCN102274296BProtectiveHas a protective therapeutic effectNervous disorderCarbohydrate active ingredientsDiseaseLactate dehydrogenase
The invention discloses an application of tenuigenin in preparing a medicament for preventing or treating a PD and improving the movement coordination capability. Tenuigenin has a certain protection effect on cells and animal models of the PD, and allows the lactate dehydrogenase content to be reduced and the protein level of a rate-limiting enzyme tyrosine decarboxylase TH metabolized by dopamine to be increased by obviously increasing the cell vitality of dopaminergic neurons to make the number of positive cells of the TH in a nigral locus obviously increase. Tenuigenin has an obvious protection and treatment effect on the cells and the animal models of the PD.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Pharmaceutical composition for treating and/or preventing myocardial ischemia-reperfusion injury, and its preparation method
PendingCN109260463AIncrease protein levelsEasy to shrinkPeptide/protein ingredientsPharmaceutical non-active ingredientsDrugDiastolic function
The invention belongs to the biomedical field, in particular to a pharmaceutical composition for treating and / or preventing myocardial ischemia-reperfusion injury and a preparation method thereof. Thepharmaceutical composition is chitosan nanoparticles coated with recombinant APN protein. The pharmaceutical composition of the invention is nanoparticles prepared from recombinant APN protein and chitosan, and the encapsulation efficiency can reach 81.9%; the nanoparticles were spheroid-like particles with particle size less than 700 nm and concentrated in the range of 100-500 nm. The pharmaceutical composition can improve left ventricular systolic and diastolic function of rats with myocardial ischemia-reperfusion injury and inhibit myocardial mitochondrial autophagy.
Owner:SHANDONG UNIV QILU HOSPITAL
Pyridine compound and its preparation method and anti-gastric cancer application
ActiveCN109369620BNovel structureReduced ability to migrateOrganic active ingredientsOrganic chemistryCancer drugsHuman gastric carcinoma
Owner:SHANDONG UNIV
Application of mir‑885‑5p and mir‑224‑5p in drug preparation
ActiveCN104056279BRestore sensitivityIncreased sensitivitySenses disorderGenetic material ingredientsTherapeutic effectReceptor for activated C kinase 1
The invention belongs to the field of biological medicine and particarly relates to application of miR-885-5p and miR-224-5p to medicament preparation. The invention verifies that under an in-vitro high inflammation environment, main pathogenic cell postorbital fibroblast of Graves eye disease directly generates resistance on glucocorticoid, but miR-885-5p and miR-224-5p can increase protein level of a glucocorticoid receptor in the postorbital fibroblast, can recover sensitivity of the postorbital fibroblast on glucocorticoid, can improve treatment effect of the glucocorticoid on Graves eye disease, so that theoretical basis and experimental data are provided for clinically treating Graves eye disease. A model consisting of baseline serum miR-885-5p, miR-224-5p, TRAb and palpebral fissure width can effectively predict a patient insensitive to glucocorticoid treatment.
Owner:RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Uses of Licochalcone
ActiveCN105232501BLow toxicityExtend your lifeCosmetic preparationsOrganic active ingredientsMetabolic enzymesLicorice roots
The invention discloses novel application of echinatin. The echinatin and at least one of medically acceptable salt, ester, solvate, stereoisomer, tautomer and prodrug of the echinatin are applied to the product which has at least one of the following functions: (1) activating the signal path of Nrf2 and / or AMPK; (2) strengthening the expression of Nrf2, antioxidase and / or metabolic enzymes; (3) resisting aging; (4) inhibiting cell injury and tissue injury caused by oxidation; (5) protecting liver injury; (6) protecting chemical liver injury or oxidative liver injury; and (7) resisting vicious transformation of skin cells. The echinatin can be separated and purified from licorice root. The novel application of the echinatin provides a novel thought to researches and development of echinatin, and a series of novel products with the application are further provided.
Owner:PEKING UNIV
Human leukocyte protease inhibitor and its recombinant preparation and application
ActiveCN110964094BLose weightInhibit fatty degenerationPeptide/protein ingredientsMetabolism disorderWhite blood cellLiver steatosis
The invention relates to human leukocyte protease inhibitory factor and its recombinant preparation and application, belonging to the field of biomedicine. The amino acid sequence contained in human leukocyte protease inhibitor is: (1) the amino acid sequence shown by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3; (2) in SEQ ID NO: 1, SEQ ID NO: ID NO: 2 or the amino acid sequence obtained by connecting the N-terminal or / and C-terminal tag of the amino acid sequence shown in SEQ ID NO: 3; (3) in SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3 The amino acid sequence shown is substituted, deleted or added with one or several amino acids and has the activity of the human leukocyte protease inhibitor. The preparation method is to first construct the plasmid, then induce expression to obtain the fusion protein, and then perform renaturation and concentration after purification. The protein in the invention has important applications in the preparation of medicines for treating metabolic diseases, and can reduce body weight, inhibit the increase of fat tissue weight, and inhibit hepatic fatty degeneration.
Owner:HUAZHONG UNIV OF SCI & TECH
Application of parthenolide as CMA activator in preparation of medicine for treating fibrosis
PendingCN119424413Aincrease protein levelsOrganic active ingredientsNervous disorderFibrosisPharmaceutical drug
The invention discloses application of parthenolide as a CMA activator in preparation of a medicine for treating fibrosis, and relates to the technical field of application of natural compounds. Research results show that parthenolide is a novel CMA activator, can improve expression of LAMP2A in a dose-dependent manner within a certain concentration range, can significantly improve mRNA and protein levels of LAMP2A, can improve TGF-beta induced fibrosis phenotypes at a cellular level, and can inhibit TGF-beta stimulated HK-2 cell epithelial-mesenchymal transition (EMT) in a dose-dependent manner, so that the parthenolide can be used for preparing a medicine for treating leukocyte apoptosis. And 3T6 cell and HK-2 cell fibrogenesis.
Owner:NANHU BRAIN COMPUTER CROSS RES INST
Health-care product oral liquid for delaying senescence and preparation method thereof
PendingCN114766619APromote lowerImprove the level ofFood ingredient functionsPolysaccharide/gum food ingredientsBiotechnologyAmygdalin
The invention provides a health-care oral liquid for delaying senescence and a preparation method thereof. A polypeptide and polysaccharide co-production preparation technology is adopted for the first time, sheep placenta freeze-dried powder, fructus lycii, flos carthami, longan aril and peach kernels serve as raw materials, a mixed solution rich in polypeptide (sheep placenta polypeptide) and polysaccharide (lycium barbarum polysaccharide and longan polysaccharide) is prepared, and after seasoning, the health-care oral liquid capable of delaying senescence can be prepared. In the health-care oral liquid for delaying senescence, the polypeptide content is 700-1900mg / 100mL, the polysaccharide content is 200-2000mg / 100mL, the hydroxysafflor yellow A content is 6-10mg / 100mL, and the amygdalin content is 24-40mg / 100mL, and the preparation can obviously improve the SIRT1 protein reduction condition caused by senescence, so that the effect of delaying senescence is achieved.
Owner:中山市美太保健制品有限公司
Ethanol extract of weeping tree and its preparation method and application of ethanol extract in preparing anti-liver cancer drugs
ActiveCN112156117BLower membrane potentialImprove immunityDigestive systemBryophyta medical ingredientsApoptosisCaspase
The invention provides an ethanol extract of weeping tree, a preparation method thereof and an application of the ethanol extract of weeping bark in the preparation of anti-liver cancer drugs, belonging to the field of medicine. According to the preparation method of the alcohol extract of the weeping moss, the ethanol is used to extract the ethanol to obtain the ethanol extract of the weeping moss. The results of the examples show that the ethanol extract of weeping tree in the present invention inhibits the growth of liver cancer cells in a dose-dependent manner, and has no toxic effect on the spleen cells of mice; Activate the caspase signaling pathway and induce the apoptosis of liver cancer cells; the ethanol extract can also significantly increase the spleen index and the number of immune cells in mice, thereby improving the body's immunity and further improving the anti-tumor effect. The ethanol extract prepared by the invention has remarkable antitumor effect, is a pure natural component, is safe and non-toxic, and lays a foundation for the research and development of novel anti-liver cancer drugs.
Owner:XINJIANG QIANJIN RONGYAO INVESTMENT CO LTD
Human single chain antibody and application thereof
ActiveCN108059679APromote liver damage repairInhibition of hydroxylation activityPolypeptide with localisation/targeting motifAntibody mimetics/scaffoldsPhage antibodiesSingle-Chain Antibodies
The invention belongs to the field of antibody medicine, discloses human single chain antibody namely PHD2-resistant human single chain antibody INP and HD2-resistant human intracellular single chainantibody ER-INP and discloses polynucleotide for encoding the human single chain antibody, a carrier containing the polynucleotide and application. The human single chain antibody is screened by utilizing a phage antibody library technology and prepared by utilizing a genetic engineering method. The human single chain antibody INP and ER-INP disclosed by the invention is a low-toxicity, high-efficiency and specific active molecule for inhibiting PHD2 hydroxylation activity, and toxic and side effects of heterologous antibody which is applied to a human body are avoided. Meanwhile, the human single chain antibody is micromolecular single chain antibody and has the advantages of small molecular weight, low immunogenicity and the like; in addition, endoplasmic reticulum location signals are introduced , so that the human intracellular single chain antibody ER-INP can efficiently and stably inhibit PHD2 hydroxylation activity in cells, can effectively improve HIF protein level, promotes angiogenesis damage repair of tissues like liver and the like and has a protecting effect on tissue damage.
Owner:JILIN UNIV
Safe and healthy mortality-reducing feed specially used for sows
InactiveCN107691768ATo promote metabolismImprove immunityFood processingAnimal feeding stuffCase fatality rateAnimal science
The invention discloses safe and healthy mortality-reducing feed specially used for sows. The feed is prepared from the following raw materials in parts by weight: 65-70 parts of a main material, 10-18 parts of expanded soybean meal, 4-12 parts of sesame seed meal, 2-8 parts of shrimp meal, 2-4 parts of full cream milk powder, 1-4 parts of earthworm powder, 1-2 parts of a Chinese herbal medicine additive, 0.1-0.3 part of chitosan, 0.1-0.2 part of ferric lysine, 0.1-0.2 part of manganese threonine, 0.01-0.02 part of bacillus subtilis and 4-8 parts of an adhesive. The safe and healthy mortality-reducing feed, provided by the invention, specially used for the sows is comprehensive in nutrition, can promote the metabolism of the sows, enhance the immunity of the sows and reduce the body weightloss of the postpartum sows, and improves the levels of energy and protein of the sows, especially the sows in a lactation period; furthermore, the feed is free from any antibiotic, thus not having any problem of drug resistance.
Owner:全椒县王震家禽养殖专业合作社
Protein feed rich in small peptides and multi-enzyme bacteria and preparation method thereof
InactiveCN101642187BReduce excess residueEnhance physical fitnessFood processingAnimal feeding stuffBiotechnologyFood borne
Owner:张培举
Application of dna tetrahedron in preparation of medicine for treating Alzheimer's disease
ActiveCN109806274BKeep alivePromote proliferationOrganic active ingredientsNervous disorderDiseaseApoptosis
The present invention provides the use of DNA tetrahedron in the preparation of medicines for promoting nerve repair. The DNA tetrahedron is assembled into a tetrahedral structure by four single-stranded DNAs through complementary base pairing; each edge of the tetrahedron is double Strand DNA structure. The DNA tetrahedron of the invention can protect nerve cells in the environment of beta amyloid protein and inhibit their apoptosis. The invention has good application prospect in the preparation of Alzheimer's disease medicine.
Owner:CHENGDU TENGDASHU NANO BIOTECHNOLOGY CO LTD