35results about How to "Increase protein levels" patented technology

The invention provides application of a DNA (Deoxyribonucleic Acid) tetrahedron to preparation of a medicament for treating Alzheimer's disease. The DNA tetrahedron is assembled into a tetrahedron structure from four single-chain DNAs in a complementary base pairing manner; each edge of the tetrahedron is of a dual-chain DNA structure. The DNA tetrahedron provided by the invention can protect nerve cells in an amyloid-beta protein environment and restrain nerve cell apoptosis. The DNA tetrahedron has a very good application prospect in the preparation of the medicament for treating the Alzheimer's disease.

The present invention provides a pyridine compound WXSA‑051B designed and synthesized against the enzyme active site to inhibit the enzyme activity of RBP2, and also provides its preparation method. The test proves that the compound can increase the H3K4me3 protein level in human gastric cancer cell BGC‑823 Significantly increased, it has obvious inhibitory effect on RBP2 enzyme activity, and can reduce the migration ability of human gastric cancer cell BGC‑823. The compound of the present invention can be used as a gastric cancer inhibitor to prepare anti-gastric cancer drugs. The compound structure is as follows.

The invention relates to protein feed rich in small peptides and multi-enzyme strains and a preparation method thereof. The protein feed is prepared by fermenting soybean meal, cottonseed meal, rapeseed meal, bone meal, wheat bran, common salt, light calcium carbonate, water and strains in a fermentation bin. The preparation method of the protein feed comprises the following steps: mixing the soybean meal, the cottonseed meal, the rapeseed meal, the bone meal, the wheat bran, the common salt and the light calcium carbonate in percentage by weight; adding 20-30 percent of water; sending the mixture to an air steamer; adding high-pressure steam to the air steamer so as to increase the air pressure to 1-2 Mpa and the temperature to 140-200 DEG C; keeping the pressure for 4-6 minutes; momentarily releasing the mixture in the air steamer; sending the mixture to the fermentation bin; inoculating 3-5 percent of strains when the temperature of the mixture falls to 30-37 DEG C; fermenting for 72 hours at the temperature of 32-37 DEG C; discharging from the bin; and bagging to obtain a finished product. The product has strong disease-resistant function and low cost, increases the production of animal by-products by more than 20 percent, is nontoxic, harmless and pollution-free and can inhibit food-borne diseases represented in cancers and subhealth phenomena from spreading.