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Application of tenuigenin in preparing medicament for preventing or treating parkinson' disease (PD)

A technology of polygala saponin and medicine, which is applied in the direction of medicine combination, medicine formula, plant raw materials, etc.

Active Publication Date: 2013-05-08
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing drugs and treatment methods cannot meet people's needs, and drugs that can effectively improve the symptoms of Parkinson's disease, delay disease progression and have neuroprotective effects are available

Method used

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  • Application of tenuigenin in preparing medicament for preventing or treating parkinson' disease (PD)
  • Application of tenuigenin in preparing medicament for preventing or treating parkinson' disease (PD)
  • Application of tenuigenin in preparing medicament for preventing or treating parkinson' disease (PD)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136] Embodiment 1: Capsules

[0137] Polygala saponin 20g, made into capsules by conventional technology.

[0138] Please give the daily dose

[0139] The daily dosage for adults (weight 60kg) is lgtid or 3gqd.

Embodiment 2

[0140] Embodiment 2: capsules

[0141] Take 33g of polygala saponin, add appropriate amount of excipients, and make capsules.

Embodiment 3

[0142] Example 3 tablet

[0143] Polygala saponin 30g plus appropriate amount of auxiliary materials, made into granules, dried, compressed into tablets, coated with sugar, ready to be obtained.

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Abstract

The invention discloses an application of tenuigenin in preparing a medicament for preventing or treating a PD and improving the movement coordination capability. Tenuigenin has a certain protection effect on cells and animal models of the PD, and allows the lactate dehydrogenase content to be reduced and the protein level of a rate-limiting enzyme tyrosine decarboxylase TH metabolized by dopamine to be increased by obviously increasing the cell vitality of dopaminergic neurons to make the number of positive cells of the TH in a nigral locus obviously increase. Tenuigenin has an obvious protection and treatment effect on the cells and the animal models of the PD.

Description

Technical field: [0001] The invention relates to the application of polygala saponin in the preparation of drugs for preventing and treating Parkinson's disease, and belongs to the field of traditional Chinese medicine. technical background: [0002] The issue of "population aging" is a huge challenge that every country in the world will face in the 21st century. There are more than 600 million elderly people in the world (60 years old and above, the same below unless otherwise specified), and by the end of the first half century of the 21st century, that is, by 2050, the world's elderly population will increase significantly to 20%, that is, every 5 people will be One is an elderly person. "Aging" is indeed a challenge in the 21st century. At present, population aging has become an important demographic phenomenon in the process of economic and social development. By the end of 2006, the elderly population in Beijing had reached 2.36 million, accounting for 14.9% of the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/70A61K36/69A61P25/16A61P25/14
Inventor 王晓民梁志刚
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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