Probiotic and application thereof in gastric injury

A technology of lactic acid bacteria and microorganisms, applied in the field of microorganisms, can solve the problems of blood vessel wall cell rupture and gastric mucosal damage, and achieve the effect of inhibiting gastric juice secretion, reducing the area of ​​gastric mucosal damage, and inhibiting the apoptosis of gastric mucosal epithelial cells

Pending Publication Date: 2020-09-22
CHONGQING UNIV OF EDUCATION +1
View PDF7 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hydrochloric acid may also cause damage to the gastric mucosa, and ethanol may reach the mucosa and induce rupture of blood vessel wall cells

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Probiotic and application thereof in gastric injury
  • Probiotic and application thereof in gastric injury
  • Probiotic and application thereof in gastric injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Materials and Methods

[0024] 1.1 Laboratory strains

[0025] Lactobacillus plantarum HFY09 was isolated from naturally fermented yak yoghurt and identified as lactic acid bacteria, LAB by 16S rDNA sequence. (CGMCC for short, address: Institute of Microbiology, Chinese Academy of Sciences, No. 3, Yard 1, Beichen West Road, Chaoyang District, Beijing), and the deposit registration number is CGMCC No.16633.

[0026] The Lactobacillus plantarum HFY09 isolated and purified from the yak yogurt sample showed positive Gram staining; the color of the colonies was mostly white or milky white, the shape was round, the edges were neat, and the surface was moist and smooth. Under a 100-fold oil microscope, the cells There are long rods, short rods, and spherical shapes, and there is no budding.

[0027] The 16S rDNA base sequence of the bacterial strain HFY09 of the present invention is shown in SEQ ID No.1; the sequencing results are compared on the NCBI website (http: / / blas...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a probiotic and an application thereof in the gastric injury, and belongs to the technical field of microorganisms. The Lactobacillus plantarum HFY09 belongs to lactic acid bacteria (LAB), and a preservation number is CGMCC No.16633. A hydrochloric acid / ethanol acute gastric injury model is used to evaluate the preventive effect of the Lactobacillus plantarum HFY09 on the gastric injury. The results show that the HFY09 can inhibit gastric juice secretion, maintains the normal pH value of gastric acid, reduces a gastric mucosal injury area, can inhibit stomach mucosal epithelial cell apoptosis, plays a biological role, and is positively correlated with the concentration. The HFY09 can be used in the production of probiotics or functional foods, and a theoretical basis is provided for the further development and utilization of the HFY09.

Description

technical field [0001] The invention relates to the technical field of microbes, in particular to a probiotic and its application in gastric injury. Background technique [0002] Gastric injury is an infectious or chemical attack agent that disrupts the mucosal defense system, causing gastric epithelial damage or ulceration. Current research shows that bacteria, drugs, smoking and drinking can cause damage to the gastric mucosa. Ethanol is the main ingredient used in liquid alcohol and beverages because it is fat-soluble and produces acetaldehyde molecules with strong carcinogenic effects, starting from entering the mouth and continuing when entering the blood circulation. Although the gastric mucosa can metabolize ethanol and acetaldehyde through alcohol dehydrogenase and acetaldehyde dehydrogenase, the carcinogenic effect of acetaldehyde should not be underestimated. Therefore, alcoholism can cause acute erosive and hemorrhagic gastritis, and long-term drinking can cause...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K35/747A61P1/00C12R1/25
CPCA61K35/747A61P1/00C12R2001/25C12N1/205
Inventor 赵欣黎芳
Owner CHONGQING UNIV OF EDUCATION
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap