The invention discloses health-care oral liquid for inhibiting alcohol absorption and promoting alcohol metabolism and a preparation method thereof, and belongs to health-care food. The health-care oral liquid comprises a water extract of a mixture of cortex araltae, polygala tenuifolia, turnjujube, kudzu vine root, mulberry, broccoli, hawthorn and fructus amomi, and honey, chitosan, fructo-oligosaccharide and purified water. The preparation method comprises the following steps: extracting and treating raw materials, performing water reflux extraction, concentrating, performing alcohol precipitation, diluting by using purified water, dissolving a sugar-type sweetener, mixing herbal raw liquid and the sugar-type sweetener, filtering, and subpackaging to obtain a final product. The health-care oral liquid has the beneficial effects as follows: with the cortex araltae as a monarch drug, and in combination with the kudzu vine root, the hawthorn, the fructus amomi, the polygala tenuifolia and the mulberry, a multi-component multi-target and length-coordination synergistic effect is achieved; through a formulation of natural components, the health-care oral liquid can reduce harms of alcohol to a human body from three mechanisms of preventing the alcohol absorption, decomposing the alcohol to protect the liver, and protecting the stomach, thus achieving an alcoholism eliminating effect; the alcoholism eliminating effect, the health-care effect and the safety of the health-care oral liquid are significantly broken through and improved.