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Gastric mucosa wound surface protection glue with thixotropy and acid sensitivity and application of gastric mucosa wound surface protection glue

A technology of protective glue and gastric mucosa, applied in the field of biomedicine, can solve problems such as easy to fall off, cannot fully exert the protective effect of gastric mucosa, and achieve the effect of promoting ulcer healing

Pending Publication Date: 2021-12-10
戴钲昊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent only uses purely physical principles to protect the gastric mucosa. The cross-linking agent used is acid-soluble calcium, which is insoluble in neutral solutions and is in the form of particles. It is suitable for oral use and is not suitable for injection through syringes.
In addition, the adhesives used in the product are anionic polymers and neutral polymers instead of adhesives. The surface of the gastric mucosa is also anionic, so it cannot be well adhered to the wound surface of the gastric mucosa, and it is very easy to fall off. Give full play to the protective effect of gastric mucosa

Method used

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  • Gastric mucosa wound surface protection glue with thixotropy and acid sensitivity and application of gastric mucosa wound surface protection glue
  • Gastric mucosa wound surface protection glue with thixotropy and acid sensitivity and application of gastric mucosa wound surface protection glue
  • Gastric mucosa wound surface protection glue with thixotropy and acid sensitivity and application of gastric mucosa wound surface protection glue

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Potassium alginate 12 grams

[0031] 2. Glucomannan 2 grams

[0032] 3. Polylysine 12g

[0033] 4. β-glucan 0.2g

[0034] 5. Glycerin 10g

[0035] 6. Sodium acetate 3g

[0036] Component 1: Dissolve 7.5 grams of lithium magnesium silicate in 500 ml of physiological saline adjusted to pH 8.0 with 1 mol of sodium hydroxide and mix well, then add the above ingredients and stir until completely dissolved, pack in 5 ml bottles, and sterilize by high-temperature steam.

[0037] Component 2: The solidification solution is prepared into a 1.1% aqueous solution with calcium chloride, packed in 5ml bottles, and sterilized by high-temperature steam.

Embodiment 2

[0039] 1. Amidated low methoxyl pectin 6g

[0040] 2. Glucomannan 2g

[0041] 3 Potassium alginate 8g

[0042] 4. Chitosan 12g

[0043] 5. Oat glucan 0.2g

[0044] 6. Glycerin 10g

[0045] 7. Sodium gluconate 1g

[0046] Component 1: Dissolve 7.5 grams of lithium magnesium silicate in 500 ml of physiological saline adjusted to pH 8.0 with sodium bicarbonate and mix evenly, then add the above ingredients and stir until completely dissolved, pack in 5 ml bottles, and sterilize by high-temperature steam.

[0047] Component 2: The solidification solution is prepared into a 1.1% aqueous solution with calcium chloride, packed in 5ml bottles, and sterilized by high-temperature steam.

Embodiment 3

[0049] 1. Sodium alginate 12g

[0050] 2. Glucomannan 2.5g

[0051] 3. Polylysine 4g

[0052] 4. Oat glucan 0.2g

[0053] 5. Polyvinyl alcohol 2.5g

[0054] 6. Sodium citrate 5g

[0055] Component 1: Dissolve 7.5 grams of lithium magnesium silicate in 500 ml of physiological saline adjusted to pH 8.0 with 1 mol of sodium hydroxide and mix well, then add the above ingredients and stir until completely dissolved, pack in 5 ml bottles, and sterilize by high-temperature steam.

[0056] Component 2: The solidification solution is prepared into a 2% aqueous solution with calcium gluconate, packed in 5ml bottles, and sterilized by high-temperature steam.

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Abstract

The invention provides gastric mucosa wound surface protection glue with thixotropy and acid sensitivity and an application of the gastric mucosa wound surface protection glue, and belongs to the field of biological medicine preparations. The gastric mucosa wound surface protection glue with thixotropy comprises the following effective components: a tackifier, an acid-sensitive gelling substance, a thixotropic agent, a plasticizer, a retarder and a pH value regulator, wherein the pH value of the gastric injury mucosa wound surface protection glue is greater than or equal to 7. Curing liquid can also be contained and is used for curing the protection glue at a specified position. The protection glue can form a colloidal film on the surface of ulcer to promote healing of the ulcer. In addition, the product has thixotropy and is kept in a non-flowing state on the wound surface within a short time, then the protection glue is rapidly fixed to the surface of the damaged mucosa through the curing liquid, and the flowing problem of the protection glue is solved. Animal experiments show that the gastric mucosa wound surface protection glue can obviously promote the repair of injured gastric mucosa, so that the gastric mucosa wound surface protection glue has the effects of promoting healing and protecting gastric mucosa injury.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a thixotropic and acid-sensitive gastric mucosal wound protective glue suitable for spraying on the surface of the damaged mucosa of the digestive tract through a digestive tract endoscope, and a preparation method and application thereof. Background technique [0002] Endoscopic gastric mucosal resection and gastric mucosal dissection are minimally invasive surgeries for the resection of early gastric cancer and benign gastric tumors. They can not only achieve the goal of radically curing early gastric cancer, but also have the advantages of less trauma and less impact on the quality of life of patients. Gradually replace some traditional surgery. Minimally invasive surgery for early cancer and benign tumor resection of esophagus and colon also replaces some traditional surgical operations. However, at present, the postoperative wound is only treated with hemostasis, and th...

Claims

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Application Information

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IPC IPC(8): A61K38/39
CPCA61K31/715A61K31/716A61K38/39A61K38/1833A61K38/1808A61K38/1825A61K38/1858A61K38/18A61K9/06A61K47/36A61K47/42A61K47/34A61K47/10A61K47/26A61K47/02A61P1/04A61P1/00A61K2300/00
Inventor 戴钲昊
Owner 戴钲昊
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