Digestive tract submucous injection elevating agent and application thereof

A technology for protuberance and digestive tract, which is applied in the field of submucosal injection of protuberance in the digestive tract, can solve the problems of high price, difficult to obtain hyaluronic acid, stimulate tumor growth factors, etc., and achieve the effect of protecting surgical wounds and promoting wound healing.

Inactive Publication Date: 2019-12-20
HANGZHOU YINGJIAN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there is no perforation rate when hyaluronic acid is used as a submucosal material for ESD. However, hyaluronic acid is not easy to obtain and is expensive, and it has the disadvantage of stimulating tumor growth factors and stimulating the proliferation of tumor cells in the wound site

Method used

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  • Digestive tract submucous injection elevating agent and application thereof
  • Digestive tract submucous injection elevating agent and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Potassium alginate 12 grams

[0027] 2. Calcium chloride 1 g

[0028] 3. Sodium citrate 2 grams

[0029] 4. Polylysine 10g

[0030] The above ingredients are dissolved in 1500 ml of physiological salt solution adjusted to pH 8.0 by 1 mol of sodium hydroxide, packed in 15 ml per bottle, and sterilized by high-temperature steam to obtain an injection swelling agent.

Embodiment 2

[0032] 1. Amidated low methoxyl pectin 15g

[0033] 2. Calcium chloride 1 g

[0034] 3. Sodium citrate 2.5 grams

[0035] 4. Polylysine 12g

[0036] The above ingredients are dissolved in 1500ml of physiological salt solution adjusted to pH 8.0 with 1mol sodium hydroxide, packed in 5ml bottles, and sterilized by high-temperature steam.

Embodiment 3

[0038] 1. Sodium alginate 11g

[0039] 2. Sodium citrate 4 grams

[0040] 3. Calcium chloride 1.5 grams

[0041] 4. Polylysine 10g

[0042] The above ingredients are dissolved in 1500ml of physiological salt solution adjusted to pH 8.0 with 1mol sodium hydroxide, packed in 15ml bottles, and sterilized by high-temperature steam.

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Abstract

The invention provides a digestive tract submucous injection elevating agent which comprises colloidal substances and biological bonding agents, wherein effective ingredients of the colloidal substance are gel forming substances, water-soluble calcium salts and calcium ion complexing agents; the gel forming substances are one or several kinds of biological bonding agents of pectin, alginate, deacetylated gellan gum and are polylysine; the biological bonding agents are polylysine; and the pH value of the injection elevating agent is not smaller than 7. The injection elevating agent can be conveniently and fast injected to a position under the mucosa, so that a mucosa layer and a muscle layer are separated, and the mucosa peeling is convenient; in addition, after the mucosa peeling, a surgery wound is effectively protected; bleeding is stopped; and wound healing is promoted.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a swelling agent suitable for submucosal injection of the digestive tract and its application. Background technique [0002] Endoscopic gastric mucosal resection and gastric mucosal dissection are minimally invasive surgeries for the resection of early gastric cancer and benign gastric tumors. They can not only achieve the goal of radically curing early gastric cancer, but also have the advantages of less trauma and less impact on the quality of life of patients. Gradually replace some traditional surgery. Minimally invasive surgery for early cancer and benign tumor resection of esophagus and colon also replaces some traditional surgical operations. Endoscopic mucosal dissection requires good endoscopic technique, but serious complications such as bleeding and perforation may still occur during and after the operation. Therefore, how to avoid or reduce the occurrence of com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/00A61L31/14A61L31/16
CPCA61L31/00A61L31/042A61L31/06A61L31/14A61L31/16A61L2300/232A61L2300/412A61L2300/418A61L2400/04A61L2400/06C08L5/04C08L5/06C08L5/00C08L77/04
Inventor 戴建英
Owner HANGZHOU YINGJIAN BIOTECHNOLOGY CO LTD
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