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Temperature-sensitive digestive tract mucous membrane protective glue

A temperature-sensitive, mucosal protection technology, applied in the field of biomedicine, can solve problems such as limited use

Pending Publication Date: 2020-12-29
戴建英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these materials are difficult to fix on the wound surface, which limits their clinical application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1. Poloxamer 407 17g

[0020] 2. Poloxamer 188 1 g

[0021] 3. Hydroxypropyl methylcellulose 1 g

[0022] __________________________________________________________________

[0023] The above ingredients were dissolved in 60ml of normal saline at 4°C, and the solution was completely transparent, then the volume was adjusted to 100ml, each bottle was packaged in 5ml, and sterilized by high temperature steam. Store at low temperature.

Embodiment 2

[0025] 1. Poloxamer 407 30g

[0026] 2. Poloxamer 188 2 grams

[0027] 3. Hydroxypropyl methylcellulose 1 g

[0028] ____________________________________________________________________

[0029] The above ingredients were dissolved in 60ml of normal saline at 4°C, and the solution was completely transparent, then the volume was adjusted to 100ml, each bottle was packaged in 5ml, and sterilized by high temperature steam. Store at low temperature.

Embodiment 3

[0031] 1. Hydroxybutyl Chitosan 5g

[0032] 2. Poloxamer 188 0.5 g

[0033] 3. Polylysine 2 grams

[0034] ____________________________________________________________________

[0035] The above ingredients were dissolved in 60ml of normal saline at 4°C, and the solution was completely transparent, then the volume was adjusted to 100ml, each bottle was packaged in 5ml, and sterilized by high temperature steam. Store at low temperature.

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PUM

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Abstract

The invention relates to a temperature-sensitive digestive tract injury mucous membrane protective glue, and belongs to the field of biomedical preparations. The digestive tract injury mucous membraneprotective glue comprises a temperature-sensitive biological material, a gelatinization temperature regulator, a biological adhesive and a dissolving solution, wherein the weight percentage ratio ofthe temperature-sensitive biological material to the gelatinization temperature regulator to the biological adhesive is (1-30): (0.5-5): (0.3-5). Under the action of the room temperature (25 DEG C) orbelow, the protective glue is liquid and forms a colloidal film at the body temperature (37 DEG C), so that the irritating effect of intestinal tract digestive juice on injured mucous membranes of digestive tracts is avoided, and the healing of wound surfaces is promoted. Animal tests show that the temperature-sensitive digestive tract injury mucous membrane protective glue can obviously promoterepair of injured mucous membranes, so that the temperature-sensitive digestive tract injury mucous membrane protective glue has the effects of promoting healing and protecting esophagus, stomach andintestinal mucous membrane injuries.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a temperature-sensitive digestive tract mucosa protective glue suitable for spraying endoscopes on the surface of the damaged mucosa of the digestive tract. Background technique [0002] Gastrointestinal mucosal injury occurs from the esophagus, stomach, duodenum to rectum, some injuries are caused by diseases, and some are caused by surgery. Endoscopic gastric mucosal resection and gastric mucosal dissection are minimally invasive surgeries for the resection of early gastric cancer and benign gastric tumors. They can not only achieve the goal of radically curing early gastric cancer, but also have the advantages of less trauma and less impact on the quality of life of patients. Gradually replace some traditional surgery. Minimally invasive surgery for early cancer and benign tumor resection of esophagus and colon also replaces some traditional surgical operations. However,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/08A61L24/06A61L24/04A61K47/10A61K47/38A61K47/36A61K47/32A61K47/34A61P1/04A61P35/00
CPCA61L24/001A61L24/0015A61L24/043A61K47/10A61K47/38A61K47/36A61K47/32A61K47/34A61P1/04A61P35/00A61L2300/416A61L2300/412C08L71/02C08L1/284C08L5/08C08L77/02C08L33/24
Inventor 戴建英
Owner 戴建英
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