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Composition with gastric mucosal lesion protection effect and preparation method thereof

A technology for protection and gastric mucosal injury, which is applied in the field of composition with protective effect on gastric mucosal injury and its preparation, which can solve the problems of human body prone to tolerance, cure symptoms but not the root cause, and repeated attacks, and achieve the protective effect of gastric mucosal injury Obvious, effective, resistance-enhancing effect

Active Publication Date: 2021-10-15
HEBEI YUZHILIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs often have side effects, and long-term use is prone to human tolerance, curative effect decline, and there are problems of recurrent attacks, treating the symptoms but not the root cause, while traditional Chinese medicine is mainly for maintenance, focusing on recuperation, treating the symptoms and the root cause

Method used

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  • Composition with gastric mucosal lesion protection effect and preparation method thereof
  • Composition with gastric mucosal lesion protection effect and preparation method thereof
  • Composition with gastric mucosal lesion protection effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0040] Preparation Example 1: Hericium erinaceus extract

[0041] 1) Get dried Hericium erinaceus, pulverize, and cross a 120-mesh sieve to obtain dried Hericium erinaceus powder;

[0042] 2) Add the dry powder of Hericium erinaceus into deionized water and boil for 30-45 minutes, stir continuously during the boiling process, centrifuge, and separate the supernatant a;

[0043] 3) Add deionized water to the precipitate and boil for 30-45min, stir continuously during the boiling process, centrifuge, and separate the supernatant b;

[0044] 4) supernatant a and supernatant b were mixed and concentrated, freeze-dried to obtain Hericium erinaceus extract.

preparation example 2

[0045] Preparation example 2: morel extract

[0046] 1) Take Morchella, wash and dry it, crush it through a 100-mesh sieve to obtain a powder, add 0.1-1% powder weight of 5`-phosphodiesterase liquid to the powder, and at 50°C, the pH value is Under the condition of 5-6, enzymatically hydrolyze for 2 hours, then inactivate the enzyme, and filter to obtain the first enzymatic hydrolyzate of Morchella and the first filter residue;

[0047] 2) Adding 1-5% papain liquid by the weight of the first filter residue to the first filter residue, enzymatically hydrolyzing it for 1.5 hours at 45° C. with a pH value of 4.5-5.5, then inactivating the enzyme, and filtering to obtain Morchella The second enzymatic solution and the second filter residue;

[0048] 3) Add 0.1-0.5% 5′-phosphodiesterase solution by weight of the second filter residue to the second filter residue, enzymolyze it for 2 hours at 50-55°C and pH value of 6-7, and then inactivate the enzyme , filtered to obtain the thir...

preparation example 3

[0050] Preparation example 3: white and extract:

[0051] Grind the crude product of Baiji, pass through a 80-100 mesh sieve, weigh the sieved Baiji powder, add 8-10 times the mass of 95% ethanol to reflux and extract for 3-5 times, extract for 0.5-1h each time, and combine the extracts Freeze-drying to obtain dry powdered white and extract.

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Abstract

The invention provides a composition with a gastric mucosal lesion protection effect, which is prepared from the following components in parts by weight: 50 to 70 parts of hericium erinaceus extract, 40 to 60 parts of morchella esculenta extract, 30 to 50 parts of rhizoma bletillae extract, 20 to 40 parts of fingered citron extract, 260 to 340 parts of sea buckthron oil and 10 to 30 parts of beewax. Compared with the prior art, according to the theory of traditional Chinese medicine, aiming at the pathogenesis of insufficiency of qi in spleen and stomach and unsmooth qi and blood, the hericium erinaceus extract, the morchella extract, the rhizoma bletillae extract and the fingered citron extract creatively form the traditional Chinese medicine composition, and the hericium erinaceus extract in the formula strengthens the spleen and stomach, is particularly suitable for spleen and stomach meridians and serves as a monarch drug. Toadstool harmonizes stomach, promotes digestion, reduces phlegm and regulates qi; the rhizoma bletillae has the effects of inducing astringency, promoting tissue regeneration, eliminating stagnation and removing stasis, promoting digestion, relieving stasis, promoting tissue regeneration, eliminating rotting, regulating qi and removing stasis, and is used as a ministerial drug together, so that the bleeding volume of gastric mucosa is increased, oxygen supply is promoted, the resistance is enhanced, the blood circulation of the gastric mucosa is smooth, and the qi and blood of a body are smooth. The fingered citron is an adjuvant drug, has the effects of promoting the circulation of qi, tonifying the liver, warming the stomach, tonifying the spleen, arresting vomiting and the like, is soft in nature, does not lack strength, treats the liver and the spleen without hurting the body resistance, is flexible and appropriate in the formula, and plays good assistant and assistant roles.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a composition capable of protecting gastric mucosa from damage and a preparation method thereof. Background technique [0002] With the acceleration of the pace of life in modern society, people are under increasing social, psychological and work pressure, which leads to a corresponding increase in the incidence of gastric mucosal diseases. Fast-paced lifestyles, intense work and study, and excessive drinking are common causes of gastric mucosal damage. As a worldwide disease, its incidence remains high no matter in developed countries or in developing countries. According to reports, in my country's social population, more than 10% of people suffer from gastric ulcer, about 25% of people suffer from various gastritis, and the total number of gastric disease patients in the country is nearly 300 million. [0003] The gastric mucosal defense mec...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61K9/48A61K47/44A61P1/04A61K36/07A61K36/062A61K36/752A61K36/185
CPCA61K36/07A61K36/062A61K36/898A61K36/752A61K36/185A61K9/4858A61P1/04A61K2300/00
Inventor 朱志铭赵大鹏张赞李丽丽马辉韩烁培
Owner HEBEI YUZHILIN PHARMA
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