6results about How to "No toxic effects" patented technology

This invention discloses a bone repair scaffold material, its preparation method, and its application. The preparation method includes the following steps: preparation of a mineralized collagen core spinning solution; adding mangiferin to a PLGA electrospinning solution and stirring to obtain a shell spinning solution; and using the core spinning solution and the shell spinning solution, obtaining the bone repair scaffold material through coaxial electrospinning. In this invention, PLGA and mangiferin together form the shell of the scaffold structure, and the sustained release of mangiferin provides a guarantee for the anti-inflammatory and angiogenic effects of the scaffold material. Simultaneously, it simulates the fibrous structure of the bone matrix, achieving slow degradation of the core and achieving the goal of long-term promotion of bone repair.

The application discloses an ecological and environment-friendly biodegradable fiber and a preparation method thereof. The method is that first, β-cyclodextrin and polyvinyl alcohol (PVA) are subjected to a copolymerization reaction to obtain plasticized modified PVA, then the plasticized modified PVA is used as a skin layer material of the fiber, PBS is used as a core layer material, and the ecological and environment-friendly biodegradable fiber is prepared through a coaxial skin-core spinning method. The ecological and environment-friendly biodegradable fiber prepared by the method has excellent mechanical properties, has the advantage of controllable degradation compared with existing PBS fibers, and has wide market application potential in the field of soft home furnishing which has high requirements on degradation performance.

This invention belongs to the field of functional probiotic screening and application technology, specifically involving a novel strain of *Lactobacillus plantarum* (…). Lactiplantibacillus plantarum The *Lactobacillus plantarum* strain was deposited on January 15, 2026, at the China Center for Type Culture Collection (CCTCC), Wuhan University, Wuhan, China, with accession number CCTCC NO: M202026133. This strain exhibits strong antioxidant capacity, significant inhibitory and flocculating effects against hemolytic streptococci, and can significantly reduce the levels of pro-inflammatory cytokines IL-6 and IL-1β induced by hemolytic streptococci while increasing the level of the anti-inflammatory cytokine IL-22. It has no toxic effects on the body, good safety profile, and can be used to prevent colonic polyps and colon cancer caused by hemolytic streptococci, showing broad application prospects.

The invention discloses lactobacillus plantarum with high ACE (angiotensin converting enzyme) inhibitory activity and application of the lactobacillus plantarum, and belongs to the field of microbial medicines. The lactobacillus plantarum is classified and named as Lactiplantarum P517 and is preserved in the China Center for Type Culture Collection, the preservation number is CCTCC NO: M 20252435, and the 16S rDNA gene sequence of the lactobacillus plantarum is as shown in SEQ ID NO: 3. The strain is separated from feces of healthy adults, and the lactobacillus plantarum provided by the invention is gram-positive bacteria, has high ACE inhibitory activity, better oxidation resistance, better acid resistance and cholate resistance, also has excellent automatic agglutination capacity and antibacterial performance, can achieve the effect of reducing blood pressure to a certain extent, and can be used for preparing a feed additive. The method can be widely applied to production of food, health-care products, medicines and the like and has a wide prospect.

The invention discloses application of fiveleaf gynostemma herb polysaccharide in preparation of medicine for treating ulcerative colitis, the main structure of the fiveleaf gynostemma herb polysaccharide is shown in the specification, research proves that the prepared fiveleaf gynostemma herb polysaccharide has an excellent treatment effect on ulcerative colitis for the first time, activation of NLRP3 inflammasome is inhibited by activating an NRF2 anti-oxidation pathway, and the curative effect of the fiveleaf gynostemma herb polysaccharide on ulcerative colitis is improved. The bacterial flora abundance of bacteroides and thick-walled mycophylum is increased, and the bacterial flora abundance of proteobacteria is reduced, so that the ROS level is reduced, the inflammatory response is reduced, and the intestinal mucosal barrier repair of DSS mice is promoted.

The application discloses a kind of real fly luring and killing agents.The real fly luring and killing agent is composed of the following components by mass percentage: 75-85% of apple snail meat hydrolysate, 3-7% of pest toxic components, 5-15% of auxiliary materials and 2-5% of stabilizers.The apple snail meat hydrolysate is a mixture of apple snail meat after protease hydrolysis and enzyme inactivation, and the pest toxic components are Metarhizium or Beauveria.The luring and killing agent uses the protein hydrolysate of invasive species apple snail meat as the main raw material to prepare food lure, and then adds a small amount of Metarhizium / Beauveria to prepare the luring and killing agent.The synergistic effect of food lure and Metarhizium / Beauveria significantly improves the luring and killing effect on real flies.The new real fly luring and killing agent has the characteristics of high efficiency and green environmental protection.