3results about How to "No toxic effects" patented technology

This invention discloses a bone repair scaffold material, its preparation method, and its application. The preparation method includes the following steps: preparation of a mineralized collagen core spinning solution; adding mangiferin to a PLGA electrospinning solution and stirring to obtain a shell spinning solution; and using the core spinning solution and the shell spinning solution, obtaining the bone repair scaffold material through coaxial electrospinning. In this invention, PLGA and mangiferin together form the shell of the scaffold structure, and the sustained release of mangiferin provides a guarantee for the anti-inflammatory and angiogenic effects of the scaffold material. Simultaneously, it simulates the fibrous structure of the bone matrix, achieving slow degradation of the core and achieving the goal of long-term promotion of bone repair.

The application discloses an ecological and environment-friendly biodegradable fiber and a preparation method thereof. The method is that first, β-cyclodextrin and polyvinyl alcohol (PVA) are subjected to a copolymerization reaction to obtain plasticized modified PVA, then the plasticized modified PVA is used as a skin layer material of the fiber, PBS is used as a core layer material, and the ecological and environment-friendly biodegradable fiber is prepared through a coaxial skin-core spinning method. The ecological and environment-friendly biodegradable fiber prepared by the method has excellent mechanical properties, has the advantage of controllable degradation compared with existing PBS fibers, and has wide market application potential in the field of soft home furnishing which has high requirements on degradation performance.

This invention belongs to the field of functional probiotic screening and application technology, specifically involving a novel strain of *Lactobacillus plantarum* (…). Lactiplantibacillus plantarum The *Lactobacillus plantarum* strain was deposited on January 15, 2026, at the China Center for Type Culture Collection (CCTCC), Wuhan University, Wuhan, China, with accession number CCTCC NO: M202026133. This strain exhibits strong antioxidant capacity, significant inhibitory and flocculating effects against hemolytic streptococci, and can significantly reduce the levels of pro-inflammatory cytokines IL-6 and IL-1β induced by hemolytic streptococci while increasing the level of the anti-inflammatory cytokine IL-22. It has no toxic effects on the body, good safety profile, and can be used to prevent colonic polyps and colon cancer caused by hemolytic streptococci, showing broad application prospects.