Chenopodium quinoa willd extract and application thereof in preparation of medicine and food for preventing gastric mucosal lesion

A technology for gastric mucosal injury and gastric mucosal injury, applied in the field of natural products, can solve the problems of late development, achieve low cost, simple extraction method, and prevent gastric mucosal injury

Pending Publication Date: 2021-11-19
TIANJIN MODERN INNOVATIVE TCM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The development of quinoa planting and application research in China is relatively late. The large-scale planting of quinoa began in 2008. At present, it is promoted in Shanxi, Gansu, Qinghai and other regions. At present, there are few mature quinoa-related products on the market in my country.

Method used

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  • Chenopodium quinoa willd extract and application thereof in preparation of medicine and food for preventing gastric mucosal lesion
  • Chenopodium quinoa willd extract and application thereof in preparation of medicine and food for preventing gastric mucosal lesion
  • Chenopodium quinoa willd extract and application thereof in preparation of medicine and food for preventing gastric mucosal lesion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Determination of polysaccharide content

[0029] Instrument: UV-Vis spectrophotometer (Thermo Fisher, EVOLUTION 201)

[0030] Standards and reagents:

[0031] Preparation of glucose standard solution: Weigh 50 mg of glucose dried to constant weight (105°C), place it in a 50 mL volumetric flask, add distilled water to dissolve and dilute to the mark, and obtain a glucose standard solution with a concentration of 1 mg / mL.

[0032] Standard curve preparation: take 1mg / mL glucose standard solution and dilute to obtain a series of diluted standard solutions (0.01mg / mL, 0.02mg / mL, 0.03mg / mL, 0.04mg / mL, 0.05mg / mL, 0.06mg / mL ). Precisely pipette 1.0mL of each glucose standard solution, put it in a 10mL test tube, add 1.0mL of 6% phenol solution, shake fully for 5s, quickly add 5.0mL of concentrated sulfuric acid, shake for 5s, place in a boiling water bath for 10min, take out and put To room temperature, the absorbance was measured at 490 nm. Draw the standard cur...

Embodiment 2

[0042] The determination of total triterpene content of embodiment 2

[0043] Instrument: UV-Vis spectrophotometer (Thermo Fisher, EVOLUTION 201)

[0044] Standards and reagents:

[0045] Standard: Oleanolic Acid Standard Reference Substance (National Institute for Food and Drug Control)

[0046] Reagents: absolute ethanol, 95% ethanol, glacial acetic acid, perchloric acid, vanillin, concentrated sulfuric acid

[0047] Preparation of oleanolic acid standard solution: Accurately weigh 5mg of oleanolic acid standard product, place it in a 10mL volumetric flask, add methanol to dissolve and dilute to the mark, and obtain a standard solution of oleanolic acid with a concentration of 0.5mg / mL.

[0048] experiment method:

[0049](1) Determination of the optimal detection wavelength of the oleanolic acid reference substance and drawing of the standard curve: Accurately draw 0.0mL, 0.1mL, 0.2mL, 0.3mL, 0.4mL, 0.5mL, 0.6mL of the oleanolic acid standard solution respectively Put m...

Embodiment 3

[0059] Example 3 Preparation of Quinoa Extract

[0060] (1) Take quinoa 500g as raw material, add it into the aqueous solution at a mass ratio of 1:10, heat to boil, keep a slight boiling state for extraction for 15 minutes, extract 3 times, and combine the extracts to obtain the quinoa water extract;

[0061] (2) Pass the quinoa extract through a 80-120 mesh sieve to obtain the extract; centrifuge (8000rpm / min, 5min), collect the filtrate, and concentrate under reduced pressure at a temperature of 60°C and a vacuum of 0.06~0.08MPa to obtain a sugar content of 10 the concentrate;

[0062] (3) Quinoa concentrate was spray-dried to obtain quinoa extract with an extraction rate of 7.8%. Among them, the polysaccharide content is 72.9%, and the total triterpene content is 1.04%.

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Abstract

The invention discloses a preparation method of a chenopodium quinoa willd extract and application of the chenopodium quinoa willd extract in preparation of medicines and foods for preventing gastric mucosal injury. Experiments prove that the chenopodium quinoa willd extract has the effect of repairing gastric mucosal lesion, and the curative effect is exact.

Description

technical field [0001] The invention belongs to the technical field of natural products, and in particular relates to the use of quinoa extract in preparing medicine and food for preventing gastric mucosal damage. Background technique [0002] Gastric ulcer is one of the most common digestive system diseases. According to relevant statistics, the incidence of chronic gastric ulcer reaches 5%-10% worldwide. It is mainly caused by Helicobacter pylori infection, excessive drinking, long-term smoking, eating cold and stimulating food or long-term use of non-steroidal anti-inflammatory drugs (Non-steroidal Anti-inflammatory Drugs, NSAIDs). Clinically, in addition to gastric ulcers caused by Helicobacter pylori, alcohol-induced gastric mucosal injury is also common. Symptoms such as epigastric pain and indigestion caused by gastric ulcer not only seriously affect the quality of life of patients, but also cause complications such as bleeding, perforation and even cancer. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P1/04A23L33/105
CPCA61K36/185A61P1/04A23L33/105A23V2002/00A61K2236/331A61K2236/333A23V2200/32
Inventor 梁利鹏刘岱琳张静泽刘馨楠王雁生
Owner TIANJIN MODERN INNOVATIVE TCM TECH CO LTD
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