147 results about "Cardiac glycoside" patented technology

A supercritical fluid (SCF) extract of a cardiac glycoside-containing plant mass is provided. The extract can be included in a pharmaceutical composition containing an extract-solubilizing amount of solubilizer. Oleandrin is included within the extract when a cardiac glycoside-containing plant, such as Nerium oleander, is extracted by SCF extraction. The extract can also contain one or more other SCF extractable pharmacologically active agents. The composition can be used to treat a wide range of disorders that are therapeutically responsive to a cardiac glycoside.

A method of treating neurological condition in a subject by administration of a cardiac glycoside is provided. Alzheimer's disease, Huntington's disease or stroke are treated by administering a therapeutically effective amount of cardiac glycoside to a subject. The cardiac glycoside can be present in a dosage form.

A prognostic assay and kit and method of use thereof are provided. The kit and assay are used to determine the likelihood of a diseased cell or tissue having a therapeutic response to treatment with a cardiac glycoside in a disease having an etiology associated with excessive cell proliferation. The kit and assay are used to determine the ratio of isoforms of the α subunit of Na, K-ATPase obtained from the diseased cell or tissue. The kit can be used to predict the therapeutic responsiveness of cancer or tumor in a subject to treatment with a cardiac glycoside. The kit and assay can be incorporated in a method of treating a disease or disorder having an etiology associated with excessive cell proliferation with a composition comprising a cardiac glycoside.

The invention belongs to the technical field of medicaments and in particular relates to cardiac glycoside compounds with a general formula (I), as well as derivatives, stereoisomers, a racemic mixture or a non-racemic mixture of the stereoisomers and pharmaceutically acceptable acid addition salts or solvates, wherein R1 is CH3, CHO or CH2OH; R2 is H or a linear saccharide chain or a branched saccharide chain, the linear saccharide chain or the branched saccharide chain is formed by saccharides; and these acids comprise inorganic acids like hydrochloric acid, sulfuric acid, hydrobromic acid, phosphoric acid, nitric acid, carbonic acid and the like as well as organic acids like methanoic acid, acetic acid, succinic acid, citric acid, lactic acid, fumaric acid, tartaric acid, benzoic acid, p-methyl-benzenesulfonic acid, methylsulphonic acid, naphthalenesulfonic acid, gluconic acid and the like. The cardiac glycoside compounds can be obtained by separation from plants, in particular Streptocaulon plant juventas or Streptocaulon griffithii, by using multiple conventional separating means or obtained through synthesis, semisynthesis or bioconversion means. These compounds have excellent inhibiting and treatment effects on multiple tumor cells.

The present invention pertains to methods of extracting cardiac glycosides from cardiac glycoside containing plant material, such as Nerium oleander, through use of aloe. It further provides for compositions resulting from such extractions, pharmaceutical compositions, cosmetic compositions, and methods of treating skin conditions.

The invention discloses an acer truncatum leaves health bagged tea, which comprises acer truncatum leaves, plateau greenleaf tea and semen cassiae, and is prepared through the steps of washing, spreading out for drying, water removing with vapor, kneading, drying, mixing and grinding, granulating, bagging, packaging and the like. By utilizing active substances which are rich in flavone, chlorogenic acid, tannin, cardiac glycosides and the like, health pharmacological active ingredients are not damaged, and the acer truncatum leaves health bagged tea can be used for treating and preventing coronary heart disease, angina pectoris, blood circulation disabled diseases and cardiovascular diseases and has actions of virus resistance, deflammation, cholagogue, removal of free radical of the human body, removal of liver heat, improvement of eyesight and the like.

The reagent, pharmaceutical formulation, kit, and methods of the invention provides a new approach to alleviate or eliminate certain negative effects associated with the use of certain cancer treatment agents (e.g. chemotherapy therapeutics, etc.) or regimens (e.g. radio therapies, etc.), including stimulation of the hypoxic stress response in tumor cells. The reagent and pharmaceutical formulation of the invention relates to Na+ / K+-ATPase inhibitors, such as cardiac glycosides, including bufadieneolides or their corresponding aglycones (e.g., proscillaridin, scillaren, and scillarenin, etc.), especially in oral formulations and / or solid dosage forms containing more than 1 mg of active ingredients.

Methods are provided for treating arrhythmia in a manner that minimizes undesirable side effects, comprising administration of a therapeutically effective minimal dose of an A1 adenosine receptor agonist with a therapeutically effective minimal dose of a beta blocker, calcium channel blocker, or a cardiac glycoside.

Methods are provided for treating arrhythmia in a manner that minimizes undesirable side effects, comprising administration of a therapeutically effective minimal dose of an Al adenosine receptor agonist with a therapeutically effective minimal dose of a beta blocker, calcium channel blocker, or a cardiac glycoside.

The invention discloses giant embryo black kerneled rice and a method for breeding the giant embryo black kerneled rice. The method comprises the following steps of: selecting giant embryo mutation coarse rice grains by naked eyes from coarse rice of black kerneled rice M2 seeds by irradiating the black kerneled rice seeds which serve as a material by 60Co-gamma rays with a 380Gy dose according to the characteristic that the giant embryo character of rice is controlled by a single recessive gene, and the rice can be obtained by induced mutation, and breeding to form giant embryo black kerneled rice varieties by the selection of an agricultural technology and yield characters. By the method, the specific rice varieties which have the giant embryo character and a black seed coat character simultaneously can be bred simply and quickly, and the coarse rice of the giant embryo black kerneled rice is rich in special nutritional ingredients such as protein, fat, essential amino acid, anthocyanin, carotene, cardiac glycoside, dietary fibers, vitamins, gamma-aminobutyric acid and the like.

The invention relates to a cardiac glycoside compound for inducing a nuclear receptor TR3 to express. The general formula of the compound of the invention is as follows: wherein, R1 is CH3, CHO or CH2OH; R2 is H or OH; R3 is H or OH; R4 is a linear sugar chain or a branch sugar chain consisted by saccharide. The cardiac glycoside compound of the invention can induce the nuclear receptor TR3 to express, thus being capable of being used as a revulsant to be applied to the preparation of drugs which are used for preventing and treating cancer, hepatitis, atherosclerosis, etc.