159 results about "Diazole" patented technology

Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H+/K+-ATPase. The compounds are 3-substituted 1,2,4-thiadiazolo [4,5- alpha ]benzimidazole and 3-substituted imidazo[1,2-d]-1,2,4-thiadiazoles corresponding to the general formula: where X and Z either represent an optionally substituted benzene ring fused to the diazole nucleus, or represent a variety of independent chemical groupings (hydrogen, lower alkyl, halo, etc.) and Y is selected from a wide range, e.g. heterocyclics and carbonyl groups.

Disclosed is an electroluminescent device comprising a light-emitting layer including a light emitting material that contains an organometallic complex comprising (1) a metal selected from the group consisting of Ir, Rh, Os, Pt, and Pd and (2) a diazole group ligand wherein the ligand has a fused aromatic ring group including a nitrogen of the diazole as a bridgehead nitrogen. The device provides useful light emission.

Highly efficient ZnS:Mn phosphors can be obtained by using triazole or diazole compounds during homogeneous precipitation in aqueous medium. Coated layers containing such phosphors can be incorporated in Thin Film Inorganic Light Emitting Diodes.

Acridine containing cisplatin compounds have been disclosed that show greater efficacy against cancer than other cisplatin compounds. Methods of delivery of those more effective cisplatin compounds to the nucleus in cancer cells is disclosed using one or more amino acids, one or more sugars, one or more polymeric ethers, C_1-6alkylene-phenyl-NH—C(O)—R₁₅, folic acid, α_vβ₃ integrin RGD binding peptide, tamoxifen, endoxifen, epidermal growth factor receptor, antibody conjugates, kinase inhibitors, diazoles, triazoles, oxazoles, erlotinib, and/or mixtures thereof; wherein R₁₅ is a peptide.

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.

The invention provides triazolothiadiazole containing derivatives, a synthesizing method thereof and application thereof. The invention relates to 1,2-diazole containing heterocyclic compounds, which have the following chemical structural general formula. The invention discloses a chemical structure and a synthesizing method of the compounds, a using method and application of the triazolothiadiazole containing derivatives for resisting TMV viruses, a using method and application in inhibiting the growth of plant pathogenic fungi, and application of the combination of the compounds, the conventional commercial anti-virus medicaments and bactericides, herbicide and insecticide in preventing and controlling diseases, pests, weeds and virus diseases of the agriculture, forestry and gardening.

The invention belongs to the field of organic photoelectric materials, and discloses a regular polymer containing monofluorine-substituted benzo-hetero[1,3]diazole, a preparation method of the regular polymer and application of the regular polymer in the field of organic photoelectric technologies. The structural formula of the polymer is shown as the first formula (please see the formula in the description), wherein x, y and z are separately independent and represent integers ranging from 0 to 5, n represents a positive integer ranging from 3 to 100,000, X1, X2 and X3 are separately independent and are selected from O or S or Se or Te or N-R or R-C-R or R-Si-R or R-Ge-R or R-Sn-R, R represents straight chains or branch chains or circular alkyl chains of C1-C30, R1, R2, R3 and R4 are separately independent and are selected from hydrogen, an alkyl group with 1-30 carbon atoms and an alkoxy group with 1-30 carbon atoms, an alkenyl group, an aryl group, a carboxyl group, a carbonyl group, an amino group, a cyano group, a nitryl group, an ester group, halogen and a halogenated alkyl group, and Ar is selected from a non-substituted or substituted electron-deficient conjugate unit group, an electron-rich conjugate group and a conjugate unit group formed by the units. The polymer can be applied to organic solar cell devices.

The invention provides a method for preparing and synthesizing a derivative containing s-triazolothiadiazole and an application thereof. The invention relates to a heterocyclic compound containing 1,2-diazole, and the compound has the following chemical structural formula: the invention discloses the chemical structure and the synthesis method of the compound, a use method and an application of the s-triazolothiadiazole derivative in resisting TMV virus and a use method and an application in inducing the tobacco anti-TMV virus; the invention also discloses a use method and an application the compound in killing insects and inhibiting the growths of plant pathogenic fungi and simultaneously discloses a combined application of the compound and the prior merchandizing antiviral agents, germicides, herbicides and pesticides in preventing viruses and inserts in agriculture, forestry and gardening.

The invention relates to the technical field of medicines, in particular discloses a levorotatory fluoroquinolone C3 diazole methyl sulfide quaternary ammonium salt, and further discloses a preparation method and application of the levorotatory fluoroquinolone C3 diazole methyl sulfide quaternary ammonium salt in the pharmaceutical field simultaneously. The chemical structural formula of the levorotatory fluoroquinolone C3 diazole methyl sulfide quaternary ammonium salt is represented by a general formula I: the general formula I is described in the specification. The levorotatory fluoroquinolone C3 diazole methyl sulfide quaternary ammonium salt provided by the invention has stronger in-vitro cytotoxicity effect on experimental leukemia cancer cell strains and stronger anti-tumor activity, and can be mixedly prepared into anti-tumor medicines with human body acceptable acidic salts or pharmaceutical carriers.

A pigment grade corrosion inhibitor and a method of forming the inhibitor is disclosed. The inhibitor is comprised of a host species comprised of an inorganic compound having a layered structure and a guest species comprised an anionic species of a weak acid. The host species is preferably a double hydroxide having a structure of: [M(II)_1-xM(III)_x(OH⁻)₂] [Aⁿ⁻_x/n.y H₂O], where M(II) is a divalent metal cationic species, M(III) is a trivalent metal cationic species, and Aⁿ⁻ is an anionic species, preferably with the species present in a range of: 0.2≦M(III)/(M(II)+M(III))≦0.4. The guest species include: ortho-phosphoric, pyrophosphoric, tripoly-phosphoric, polyphosphoric acid; mono- and di-alkyl or aryl-esters of ortho-phosphoric and pyrophosphoric acid; metaphosphoric, trimeta-phosphoric, poly-metaphosphoric acid; phosphorous (phosphonic) acid; derivatives of phosphonic acid; alkyl and aryl esters of thio-phosphoric and dithio-phosphoric acid; molybdic, phospho-molybdic, silico-molybdic acid; boric acid; cyanamidic acid; nitrous acid; derivatives of thio- and dithiocarbonic acid, including o-alkyl esters; derivatives of dithiocarbamic acid, including N-alkyl dithiocarbamates; pyrrolidinecarbodithioic acid; thio-organic compounds functionalized with at least one —SH group of acidic character, including: 2,5-dimercapto-1,3,4-thiadiazole (DMTD), 2,4-dimercapto-s-triazolo-[4,3-b]-1,3-4 thiadiazole, trithiocyanuric acid (TMT), and dithiocyanuric acid, various N—,S— and N,N—, S,S— and N,S-substituted derivatives of the above DMTD and TMT compounds; various S-substituted derivatives of trithiocyanuric acid; dimer and polymer derivatives of the above DMTD and TMT compounds, including 5,5′ dithio-bis (1,3,4 thiadiazole-2(3H)-thione or (DMTD)₂, and (DMTD)_n, polymers of DMTD and (TMT)₂, dimers and polymers of TMT; various combinations of all the above; soluble salts of DMTD and TMT; poly-ammonium salt of DMTD or (DMTD)_n and TMT formed with polyamines; mercapto-benzothiazole, mercapto-benzoxazole, mercapto-benzimidazole, and combinations, thereof; di- and poly-mercapto compounds, including: di-mercapto derivatives of thiophene, pyrrole, furane, diazoles, and thiadiazoles; di- and tri-mercapto derivatives of pyridine, diazines, triazines, benzimidazole, and benzothiazole, including dimercaptopyridine, 2, 4-dithiohydantoine, and 2,4,-dimercapto-6-amino-5-triazine; and carboxylic and di-carboxylic acids, including ascorbic, salicylic acid, phthalic acid, nitro-phthalic acid, succinic acid, and derivatives of succinic acid, including 1-(benzothiazol-2-ylthio)succinic acid.

A lithium ion polymer electrolyte membrane and its preparation method and application relate to that field of solid electrolyte. The preparation method of the lithium ion polymer electrolyte membraneof the embodiment of the invention is that the sulfonated poly (phosphodiazole) stock solution is solidified to obtain the sulfonated poly (phosphodiazole) film, and the sulfonated poly (phosphodiazole) film is reacted with lithium salt to obtain the poly (phosphodiazole) sulfonate lithium electrolyte membrane; and the sulfonated poly (phosphodiazole) film is solidified to obtain the sulfonated poly (phosphodiazole) film; or preparing lithium poly (1, 2-diazole sulfonate) solution by sulfonated poly (1, 2-diazole sulfonate) stock solution and lithium salt, and coagulating to form membrane to obtain poly (1, 2-diazole sulfonate) lithium electrolyte membrane. The method is simple and easy to operate. The poly (phthalazinesulfonic acid) lithium electrolyte membrane of the embodiment of the invention has high room temperature ionic conductivity, good electrochemical stability, flame retardancy and excellent heat resistance; a lithium ion polymer electrolyte membrane accord to an embodimentof that present invention is used as a solid-state electrolyte membrane of a solid-state lithium battery.

The invention discloses a metal-organic coordination polymer with the organophosphorus hydrolase activity and a preparation method and application thereof. The structural unit of the polymer is [Zn(L1)0.5(L2)0.5].3DMF, wherein L1 represents 1,3-bis[di(2-diazole)-hydroxymethyl]phenyl, L2 represents 3,3',5,5'-biphenyl tetracarboxylic acid ions containing four carboxyls with no proton, DMF represents N,N-dimethyl formamide, and two DMF solvent molecules are out of order. The polymer belongs to a monoclinic system and a C2/c space group. The polymer is synthesized under the low temperature through a solvothermal method, substrate organophosphorus can be effectively hydrolyzed, when pH is equal to 9.0, the ethyl paraoxon hydrolysis activity of the 0.1 mg/mL polymer is about 28 times the hydrolysis activity with no polymer, the Vmax of ethyl paraoxon hydrolysis reaction catalysis is 0.75 micro-mol/L.min, and the Km is 2.5 mmol/L. The polymer has the potential application value for constructing biometric sensors for degrading organophosphorus poison and detecting organophosphorus.

The invention discloses a fluorescent probe based on 2-styryl indole salt type derivative long-wave emission for distinguishable detection on Cys/Hcy and application of the florescent probe. The structural formula of the fluorescent probe L is shown in the specification. The fluorescent probe L is prepared from a 2-styryl indole salt as a substrate together with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole and triethylamine through gentle and simple reaction and has long-wave emission. The fluorescent probe L is simple in synthesis step, long in long-wave emission, short in response time, only capable of recognizing Cys/Hcy in a water-containing medium, capable of implementing distinguishable detection on Cys/Hcy, good in sensitivity and applicable to detection for purposes of non-disease diagnosis and non-disease treatment in cells.

The invention discloses 2, 5-di (rhodamine B-9'-(2''-benzoyl) radical)-1, 3, 4-diazole fluorescent stain compound I and a preparation method and application thereof. The compound I has excellent dissolubility in water, emits strong fluorescent light and can be applied to being biological stain, namely cell stain, and water solution of the compound I cannot suddenly extinct in fluorescence spectrum in a range of the pH (potential of hydrogen) value from 2 to 10. The compound I can be prepared from rhodamine B and phosphorus oxychloride directly or can be prepared through intermediate compound IIN and N'-double-rhodamine B hydrazine. The invention further discloses the application of the structural formula I serving as biological stain, namely cell stain.

The invention discloses perylene tetracarboxylic carboxylic ester group polymer acceptor materials and application thereof to a solar battery. The materials include a structure as refined in formula 1, in the formula 1, M is diazosulfide, dithienyl diazosulfide, selenole, dithienyl selenole, diselenium thiophene selenole, thiophene, dithiophene, terthienyl, benzene, selenophen, diselenide thiophene, terselenide thiophene, thiophene thiophthene, benzo dithiophene, benzo ditellurium thiophene, benzo ditellurium thiophene, or one of derivatives made on the basis of the compounds. R is a linear chain with more than four carbon atoms, a branched chain or an alkyl chain containing different heteroatoms. N is a natural number of 1-1000. By introducing comonomer M on the perylene ring skeletons 1, 7 positions, the level structure of polymer materials can be adjusted, and at the same time, optical property is improved, and use ratio of the materials to light is enhanced. By introducing R, dissolubility of the polymer materials can be adjusted, and utilization of a solution processing technology with low cost is facilitated. The materials can be applied to the field of organic optoelectronics.

The invention discloses a thiadiazole-containing oxadiazole compound shown in a formula (I), a preparation method of the compound and application of the compound to control of barnyard grass and rape. The compound is a novel compound with herbicidal activity, and provides a foundation for research and development of novel pesticides.

Laevo isomer and dextroisomer of alpha-substituted 2-methyl-5-nitrodazole-1-ethanol derivative, its production, medicinal composition containing the derivative or its solvent or accepted salt and use for preparing anti-anaerobe medicine are disclosed.

The invention discloses an environment-friendly plastic adhesive and a preparation method thereof. The adhesive comprises the following components in parts by weight: 5-8 parts of rosin-based hyperbranched epoxy resin, 3-5 parts of epoxidized SBS, 4-7 parts of filler, 12-20 parts of allyl furoate/N-vinyl caprolactam/N-trihydroxymethyl methacrylamide/N-(4-cyano-3-trifluoromethylphenyl)methacrylamide/trifluoroethyl methacrylate copolymer, 3-5 parts of isocyanate group ionized modified 2,5-bis(diethylamino)phenyl-1,3,4-diazole, 0-0.3 part of dibutyltin dilaurate and 70-80 parts of a mixed solvent. The invention also provides a preparation method of the environment-friendly plastic adhesive. The environment-friendly plastic adhesive provided by the invention is high in bonding strength, good in environmental protection property, durability and aging resistance, fast in curing, high in reliability and good in weather resistance and moisture resistance.

The present invention relates to heterocyclic 1, 2-diazole compound, is especially 1, 2, 3-thiabiazole compounds, including 8 types of 1, 2, 3-thiabiazole-5-formamide derivative and their synthesis and farm chemical activity screening, including screening in tobacco mosaic virus (TMV) resisting activity, TMV resistance inducing activity, pesticidal activity and bacteriostasis activity. The present invention also discloses the use and usage of said compounds in resisting TMV, inducing TMV resistance, killing pests and inhibiting plant pathogenic fungi.

The invention provides a preparation method and application of a pH fluorescence probe. A novel fluorescence probe CM-BHNBD is designed, and is from NBD(4-nitrobenzene-2-oxalic acid-13-diazole); the fluorophore intracellular mitochondria/membrane acidification monitoring can be realized; when the method is applied to pH detection in a biological sample, the advantages of good response performance, high data accuracy, good reproducibility, high precision and the like are realized; the implementation feasibility is high.

The invention relates to an agricultural sterilization combination. The agricultural sterilization combination contains phenylate diazole and cyprodinil which are (1:100)-(100:1) in weight ratio, preferably (1:20)-(20:1). The invention further relates to agricultural bactericides containing the agricultural sterilization combination and application of the agricultural bactericides to control of fruit tree botrytis and vegetable botrytis. The sterilization combination has remarkable synergistic effect, improves sterilization effect, reduces pesticide utilization cost, reduces environment pollution and pesticide residues, enables action sites to be increased, and is favorable for overcoming and delaying generation of pesticide resistance of germs. The sterilization combination is good in safety, and has good control effect on the fruit tree botrytis and the vegetable botrytis.