17 results about "Diazole" patented technology

This invention provides an organic electroluminescent device. The organic electroluminescent device comprises a first compound having the structure shown in Formula I and a second compound having the structure shown in Formula II, wherein the first compound is a polysubstituted benzodiazole structure, and the second compound is an amine compound having a benzofuran group, a benzothiophene group, a carbazole group, or a fluorene group. This invention provides that the first and second compounds have better structural matching, better hole injection capability, and excellent charge generation capability. Combining the first and second compounds to prepare the organic electroluminescent device can reduce the device voltage, improve device efficiency, and extend device lifespan.

The application belongs to the field of fungicides, and discloses a 1,3,4-oxa / thia-diazole pyrogallol derivative, a preparation method and application, and the structure of the compound is as shown in the formula I: in the formula I, X is an oxygen atom or a sulfur atom; R is a hydrogen atom, a halogen atom or a methoxy group; the halogen is one of F, Cl and Br. The compound has the effect of inhibiting plant pathogenic fungi and preventing and treating plant fungal diseases, and can be applied to plant protection as a fungicide.

The objective is to provide a shortened manufacturing method for (alkylsulfonyl)pyridine-N-substituted amidine derivatives or (alkylsulfonyl)pyridine-diazole heterocyclic derivatives that have pest control properties. [Solution] By reacting an (alkylsulfonyl)pyridine-amidine derivative with R6-O-NH2, the corresponding (alkylsulfonyl)pyridine-N-substituted amidine derivative can be directly produced. Furthermore, this manufacturing process provides a shortened manufacturing method for (alkylsulfonyl)pyridine-diazole heterocyclic derivatives.

This invention discloses a high-fire-resistant concrete, characterized by being composed of the following components in parts by weight: 20-25 parts cement, 30-35 parts crushed stone, 10-25 parts river sand, 10-12 parts volcanic ash, 10-20 parts water, 1-3 parts epoxy-propionic acid modified octa-tetramethylcyclotetrasilazane, 0.3-0.6 parts guanidine carbonate, 1-3 parts calcium borate, 0.5-1 part waste polyarylene diazole fiber, and 0.1-0.3 parts 3-chloro-2-hydroxypropanesulfonic acid modified 2,5-bis(diethylamino)phenyl-1,3,4-diazole. This invention also discloses a method for preparing the aforementioned high-fire-resistant concrete. The high-fire-resistant concrete disclosed in this invention exhibits high fire resistance, good workability, excellent comprehensive performance, impermeability and crack resistance, durability, and high compressive strength.

The application discloses a curcumin photoaffinity probe molecule and a preparation method and application thereof, and the preparation method comprises the following steps: taking curcumin (compound II) as raw material, and reacting with 3-but-3-alkynyl-3-(2-iodoethyl) diazole alkene (compound III) under alkaline conditions to obtain the curcumin photoaffinity probe molecule (compound I), wherein a photo-crosslinking group and a biological orthogonal group are introduced at the 4th position of the curcumin photoaffinity probe molecule, the diazirine photo is the crosslinking group, can in-situ crosslink the adjacent binding protein under the condition of ultraviolet light, the alkynyl group is the biological orthogonal group, and the probe is coupled with fluorescein or biotin through a biological orthogonal coupling reaction, so that the probe is used for fluorescence detection on curcumin target protein in cells and identification of the curcumin target protein.

The invention discloses a construction method of a 1, 3-dinitrogen heterocyclic compound. According to the construction method, an acyloin compound is used as a raw material to react with an anthranilamide compound and analogues thereof, an anthranilamide compound, an anthranilic compound or various amino amide compounds in a solvent containing a catalyst and an oxidizing agent respectively, and the corresponding 1, 2, 3-triazole compound is obtained at a medium to higher yield. The invention discloses a 1, 3-diazacyclo compound. The construction method has the characteristics of cheap and easily available raw materials, moderate reaction temperature, high atom utilization rate and diversified product structures.

The application discloses 4,8-epoxy-1,3-dioxolane[4,5-d]-1,2-diazole compounds and a preparation method and application thereof, belongs to the technical field of medicines, and particularly relates to 4,8-epoxy-1,3-dioxolane[4,5-d]-1,2-diazole compounds, a preparation method thereof, and application thereof in preparation of antitumor drugs. The structural general formula of the 4,8-epoxy-1,3-dioxolane[4,5-d]-1,2-diazole compounds is as follows: wherein R1 is selected from C1-C4 alkyl, C3-C6 cycloalkyl, benzyl, methoxy-substituted benzyl, halogen-substituted benzyl, phenyl, C1-C4 alkyl-substituted phenyl, hydroxyl-substituted alkyl, and ethoxycarbonylmethyl; and R2 is selected from hydrogen, C1-C4 alkyl, and benzyl. The 4,8-epoxy-1,3-dioxolane[4,5-d]-1,2-diazole compounds provided by the method have novel structures, many modifiable sites, mild reaction conditions, cheap and readily available raw materials, few steps, simple operation, good stereoselectivity, a simple synthesis method, and are suitable for industrialized production.

Embodiments of the present disclosure are directed towards spray-dried compositions including a Hf phenol-oxadiazole complex and methods utilizing these spray-dried compositions.

The application discloses a 2-alkyl substituted 1,3,4-oxadiazole heterocyclic compound and a preparation method thereof, and belongs to the technical field of organic synthesis. The application realizes remote heteroaromatic reaction of an amide alkyl carbon hydrogen bond and a 1,3,4-oxadiazole heterocyclic compound through a free radical reaction process by using a cheap copper catalytic system, and provides a synthesis method of the 2-alkyl substituted 1,3,4-oxadiazole heterocyclic compound with high efficiency and high selectivity. The method avoids using expensive transition metal catalysts, and the reaction substrate is easy to obtain, avoids using a pre-functionalized substrate, and directly synthesizes the 2-alkyl substituted 1,3,4-oxadiazole heterocyclic compound through a double carbon hydrogen bond activation strategy. The preparation method is easy to operate, the reaction condition is mild, the post-treatment is simple, the reaction efficiency is high, the regioselectivity is good, and the substrate has wide practicality.

Disclosed is an application of a class of selenium-containing organic compounds in copper sulfide flotation collectors, including organic compound with selenium atoms as functional groups and containing single selenium atom or multiple selenium atoms, where the organic compound with selenium atoms as functional groups and containing single selenium atom or multiple selenium atoms includes but not limited to selenophene, phenylselenol and diselenide as copper collectors; and a class of organic compound containing selenium atoms combined with nitrogen, oxygen, phosphorus, sulfur and carbon, where the class of organic compound containing selenium atoms combined with nitrogen, oxygen, phosphorus, sulfur and carbon includes but not limited to selenomethyl ester, carbonyl selenomethyl ester, oxycarbonyl selenomethyl ester, selenourea, selenium nitrogen, selenoxanthonic acid, selenoxanthate, selenophosphoric acid, selenium phosphate ester, triphenylphosphine selenide, all kinds of benzoselenediazole molecules as copper collectors.

The present application relates to the technical field of medicine, in particular to a potential genotoxic impurity in a morpholine nitroimidazole raw material and preparation and a preparation method and application thereof.The potential genotoxic impurity is 2-methyl-5-nitro-1-nitrosoimidazole.A new structure compound 2-methyl-5-nitro-1-nitrosoimidazole of diazoles is found in the synthesis process of the morpholine nitroimidazole raw material for the first time.The compound is identified as a potential genotoxic impurity because of containing a nitrosamine warning structure.A method for analyzing the potential genotoxic impurity 2-methyl-5-nitro-1-nitrosoimidazole by using ultra-high performance liquid chromatography-mass spectrometry is established for the first time, which is of great significance to the quality control of the morpholine nitroimidazole raw material and preparation.The detection method provides a reference for the quality evaluation of other starting materials, intermediates and raw materials that can produce 2-methyl-5-nitro-1-nitrosoimidazole.

The present application mainly relates to triazole compounds, belongs to the technical field of medicine, and particularly relates to synthesis of advanced glycation end product receptor inhibitors and application thereof in anti-breast cancer. The present application performs skeleton transition on the structure of azirige, replaces diazole in the original structure with 1,2,4-triazole, and then performs structure derivation. The in-vitro pharmacological activity experiment results show that some derivatives have good growth inhibition effect on human triple-negative breast cancer cell line SUM149, the IC 50 value is in the order of muM to nM, the best active compound is 0.220+ / -0.034 muM; the cytotoxic activity of the rest of the compounds is lower, and the inhibition rate at the maximum test concentration (10 muM) is less than 50%.

According to the present invention, by reacting an (alkylsulfonyl)pyridinecarbonitrile derivative with an aminopyridine derivative in the presence of a Lewis acid to directly produce the amidine derivative and converting the same into an N-substituted amidine derivative, and by further producing a diazole heterocyclic compound therefrom, the compound having a pest-controlling action can be produced with a small number of steps.

The invention provides an organic compound and an organic electroluminescent device comprising the same. The organic compound has a structure as shown in a formula I, the ortho-position of R2 has a benzodiazole structure and an R1 group, and W is selected from O, S or Se. According to the organic electroluminescent device prepared from the compound shown in the formula I, the compound with the structure has the capability of improving and adjusting hole injection of the device, and is used for preparing a hole injection layer, reducing the voltage of the device and improving the efficiency of the device; more importantly, the ortho R1 group of R2 also has the effect of adjusting the conductivity of the hole injection layer, and the conductivity of the hole injection layer is reduced, so that the transverse crosstalk of the OLED panel is expected to be reduced.

An embodiment involves introducing heterocyclic 1,3-diazole (HDZ) into a PEDOT-(PSS) film, which significantly reduces the Coulomb force within the PEDOT-(PSS) and forms hydrogen bonds with PSS, thereby improving the morphology, optical properties, carrier mobility, and polymer structure of the film. The use of an optimized PEDOT-(NHDZ:PSS) film as an HTL for OPD has the effects such as better noise suppression, higher detectivity for weak light at low frequencies, wider bandwidth, and faster response speed for optical signals, and by utilizing these characteristics, the PEDOT-(NHDZ:PSS)-based OPD may successfully achieve diagnosis of cardiovascular-related diseases.