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51results about How to "Poor outcome" patented technology

System, Method And Apparatus For Tooth Implant Planning And Tooth Implant Kits

InactiveUS20100105011A1Improve the level ofFacilitate proper fixture placementDental implantsDispensing apparatusPatient dataDental implant
Systems and methods support dental implant patient scheduling and treatment process relating to packaging one or more dental appliances as a kit which is readily used by dental professional during surgery, by communicating manufacturing progress information with a doctor over a network and performing patient scheduling and treatment when the dental appliances reach a certain manufacturing progress. A network-based service may also provide a doctor with a treatment solution including a surgical kit derived from patient data.
Owner:INPRONTO

Wireless fetal monitoring system

A wireless fetal and maternal monitoring system includes a fetal sensor unit adapted to receive signals indicative of a fetal heartbeat, the sensor optionally utilizing a Doppler ultrasound sensor. A short-range transmission unit sends the signals indicative of fetal heartbeat to a gateway unit, either directly or via an auxiliary communications unit, in which case the electrical coupling between the short-range transmission unit and the auxiliary communications unit is via a wired connection. The system includes a contraction actuator actuatable upon a maternal uterine contraction, which optionally is a EMG sensor. A gateway device provides for data visualization and data securitization. The gateway device provides for remote transmission of information through a data communication network. A server adapted to receive the information from the gateway device serves to store and process the data, and an interface system to permits remote patient monitoring.
Owner:GARY & MARY WEST HEALTH INST

Systems and Methods for Affixing A Prosthetic to Tissue

Systems and methods recited herein provide for affixation of a prosthetic valve to surrounding tissue, by at least one anchor and an anchor deployment device. The prosthetic valve device may be compliant with native tissue and may receive the at least one anchor in at least one anchor receptacle to affix the prosthetic valve to native tissue. The anchor may include a distal tip, a proximal head, and a tension component, such that upon deployment into tissue the tension component is situated in a tensioned state to exert a pulling force on the distal end of the anchor.
Owner:MICRO INTERVENTIONAL DEVICES

Method and Apparatus for Skin Cancer Thermal Therapy

An apparatus for treatment of soft tissue includes a source of radiation, a handpiece which is adapted to transmit radiation emitted from the source of radiation to a region of soft tissue, resulting in irradiated soft tissue, said handpiece being positioned adjacent to or in contact with said soft tissue region, a grid element adapted to hold at least one temperature sensor in contact with or embedded in said region of soft tissue, and a microprocessor, which converts a signal from the at least one temperature sensor into a measure of damage produced in at least two components of the irradiated soft tissue, said components comprising at least one normal tissue component and at least one malignant, hypertrophic, diseased, or unwanted component.
Owner:GRADIANT RES

Genetic markers and diagnostic methods for resistance of breast cancer to hormonal therapies

This application provides a method to identify genetic markers associated with increased sensitivity or resistance to hormonal therapies using an outlier analysis. More specifically, this application discloses that amplifications on chromosomes 8 and 17 are associated with increased proliferation and poor outcome in ER-positive breast cancer, and amplicons 17q21.33-q25.1, 8p11.2 and 8q24.3 may be responsible for higher proliferation and poor outcome in the setting of antiestrogen, in particular Tamoxifen, treatment clinically observed in a subset of ER-positive, HER2-negative breast cancers. The invention also provides use of the identified genetic markers in the development of targeted treatments for antiestrogen-resistant ER-positive breast cancers as well as in improving current methods of drug response prediction.
Owner:RUTGERS THE STATE UNIV

Pharmaceutical nimodipine compositions

A modified release solid dosage product comprises a plurality of minicapsules or minispheres containing nimodipine, wherein when exposed to a use environment more than 40% of the nimodipine is released within 12 hours and wherein the Tmax is reached within 6 hours. The product may be a capsule 4 having a first population of uncoated minispheres 1 containing nimodipine for immediate release and a second population of coated minispheres 2 containing nimodipine for sustained release. There may be another population of coated minicapsules 3.
Owner:COULTER IVAN

DNA methylation markers based on epigenetic stem cell signatures in cancer

In particular aspects, stem-cell polycomb group (PcG) targets are more likely to have cancer-specific promoter DNA methylation than non-targets, indicating a stem-cell origin of cancer, where reversible gene repression is replaced by permanent silencing, locking the cell into a perpetual state of self-renewal and predisposition to subsequent malignant transformation. Exemplary aspects provide methods for identifying preferred DNA methylation markers for a cellular proliferative disorder and / or cancer and markers for developmental lineages and / or stages, based on identifying PcG protein or PcG repressive complex genomic target loci within a precursor cell (e.g., stem or progenitor cell) population, and determining, in cells of the proliferative disorder and / or cancer or cell of the particular developmental lineages and / or stages, a characteristic methylation status of the PcG target loci. Additional aspects provide methods for validating and / or monitoring a precursor cell (e.g., stem cell) population. Diagnostic and prognostic methods for ovarian and breast cancer are provided.
Owner:UNIV OF SOUTHERN CALIFORNIA +1

Sepsis detection microarray

The invention relates to the early detection of sepsis and the use of particular sets of biomarkers. Combinations of biomarkers representing changes in expression levels of specific genes are provided and, in particular, the use of microarrays to detect such changes of expression and to provide early diagnostic information is provided.
Owner:THE SEC OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTYS GOVERNMENT OF THE UK OF GREAT BRITAIN & NORTHERN IRELAND

Facilities for hybrid tissue banks

A system, workflow and facilities for hybrid tissue banks are provided with a central access way having spaces on both sides for public and private diagnostic areas, public and private clean room areas for processing, culturing and other manufacturing steps, public and private storage areas, wherein air flow is into said clean rooms and out of said diagnostic areas and said storage areas, and wherein all public facilities are on one side of the central access-way and private facilities are on the other side, and wherein there are sample pass-throughs between each area, and at least the sample pass-through into and out of the clean room processing areas comprise small enclosed chambers having two access panels (one leading to each space), wherein only one panel can open at a time. Preferably, these areas are preceded by receiving spaces and terminated by shipping spaces, which also have pass-through chambers. The rooms may be vertically separated on different floors with vertical sample transportation mechanism.
Owner:STEM CELL RESERVE

Facilities for hybrid tissue banks

A system, workflow and facilities for hybrid tissue banks are provided with a central access way having spaces on both sides for public and private diagnostic areas, public and private clean room areas for processing, culturing and other manufacturing steps, public and private storage areas, wherein air flow is into said clean rooms and out of said diagnostic areas and said storage areas, and wherein all public facilities are on one side of the central access-way and private facilities are on the other side, and wherein there are sample pass-throughs between each area, and at least the sample pass-through into and out of the clean room processing areas comprise small enclosed chambers having two access panels (one leading to each space), wherein only one panel can open at a time. Preferably, these areas are preceded by receiving spaces and terminated by shipping spaces, which also have pass-through chambers.
Owner:STEM CELL RESERVE

Glyceryl 3-hydroxybutyrates for traumatic brain injury

A method of treatment of mild to moderate non-penetrating closed traumatic brain injury and mild to moderate TBI due to surgical intervention using 3-hydroxybutyate glycerides is disclosed.
Owner:NEUROENERGY VENTURES INC

Fraud Prevention Exchange System and Method

ActiveUS20190266609A1Reduce bad loan outcomePrevent and avoid online fraudFinanceOther databases indexingData retrievalTransaction data
A fraud prevention exchange system is provided for gathering transaction data for centralized review. The system comprises a database for storing transaction data received from participating lenders and a data retrieval and processing engine for receiving transaction data including a first transaction status code and one or more transaction attributes for a pending transaction from a first participating lender; storing the first transaction status code in association with the transaction attribute(s) in the database; receiving a transaction verification request comprising at least one of the transaction attribute(s) from a second, different participating lender; determining one or more risk alerts for the at least one of the transaction attribute(s) based on the first transaction status code and one or more prior transaction status codes previously stored in the database in association with said attribute; and transmit said risk alert(s) to the second participating lender.
Owner:TRANSUNION

Post-Surgical Breast Molding Device

InactiveUS20170318867A1Close off deforming pocketEasy to createBrassieresPost operativeReoperative surgery
A post-operative bra for creating uniform breast symmetry after surgery. There are left and right side cups under the respective breasts, a left and right side longitudinal straps that wrap around the user's torso, a fastener connecting the ends of the left and right side longitudinal straps when the bra is worn by the user, air bladders mounted in the left and rights side longitudinal straps, and a pump connected to each air bladder for inflating the air bladder. The device provides pressure to the appropriate areas of the user to assist in supporting and stabilizing the breast in order to retain its proper shape.
Owner:WIESMAN IRVIN

Method and magnetic resonance system for fat saturation

In a method and a magnetic resonance (MR) system for fat saturation when acquiring MR data in a predetermined volume segment of an examination object (O), a flip angle is determined as a function of a predetermined requirement for a fat signal that is acquired by the magnetic resonance system in the volume segment, and an RF preparation pulse is emitted that has the determined flip angle. This is followed by emission of a SPAIR pulse, followed by acquisition of the MR data.
Owner:SIEMENS HEALTHCARE GMBH

Asf1b as a Prognosis Marker and Therapeutic Target in Human Cancer

The present invention provides a prognostic marker in human cancer, Asf1b, a high expression thereof being associated with a poor prognosis. The present invention also provides a method for selecting a subject affected with a cancer for an adjuvant therapy. Finally, the present invention provides a new therapeutic target for treating cancer.
Owner:INSTITUT CURIE +1

Method and apparatus for skin cancer thermal therapy

An apparatus for treatment of soft tissue includes a source of radiation, a handpiece which is adapted to transmit radiation emitted from the source of radiation to a region of soft tissue, resulting in irradiated soft tissue, said handpiece being positioned adjacent to or in contact with said soft tissue region, a grid element adapted to hold at least one temperature sensor in contact with or embedded in said region of soft tissue, and a microprocessor, which converts a signal from the at least one temperature sensor into a measure of damage produced in at least two components of the irradiated soft tissue, said components comprising at least one normal tissue component and at least one malignant, hypertrophic, diseased, or unwanted component.
Owner:GRADIANT RES

Glyceryl 3-hydroxybutyrates for traumatic brain injury

A method of treatment of mild to moderate non-penetrating closed traumatic brain injury and mild to moderate TBI due to surgical intervention using 3-hydroxybutyate glycerides is disclosed.
Owner:NEUROENERGY VENTURES INC

Modulating afferent signals to treat medical conditions

ActiveUS20150057313A1Reduce and block afferent nerve signalReduce deliveryBiocideElectrotherapyMuscle dysfunctionOrthopnea
This document provides methods and materials for modulating afferent nerve signals to treat medical conditions such as CHF, CHF respiration, dyspnea, peripheral vascular disease (e.g., peripheral arterial disease or venous insufficiency), hypertension (e.g., age-associated hypertension, resistant hypertension, or chronic refractory hypertension), COPD, sleep apnea, and chronic forms of lung disease where muscle dysfunction is a part of the disease pathophysiology. For example, methods and materials involved in using electrical and / or chemical techniques to block or reduce afferent nerve signals (e.g., nerve signals of group III and / or IV afferents coming from skeletal muscle and / or the kidneys) are provided.
Owner:MAYO FOUND FOR MEDICAL EDUCATION & RES

Detection kit used for severe septicopyemia and acute liver failure

InactiveCN103033620AGood outcomePoor outcomeMaterial analysisAntiendomysial antibodiesChronic liver failure
The invention belongs to the technical field of the immunology, and relates to a detection kit for the severe septicopyemia and the acute liver failure. The detection kit comprises a sodium citrate contained anticoagulant tube, an erythrocyte lysate, a PBS solution, a CD45 human monoclonal antibody, a CD14 human monoclonal antibody, a CD16 human monoclonal antibody, and a 1% paraformaldehyde fixing solution. The detection kit can detect the peripheral bloods of septicopyemia and acute / acute-on-chronic liver failure patients through detecting the monocyte differentiation capability in order to determine the prognosis of the above diseases. Detection results show that the obstacles of the monocyte differentiation capability of the diseases still exist; and the peripheral blood monocyte differentiation repression is closely related with the disease prognosis because the mortality of monocyte differentiation repression patients obviously increases and the monocyte differentiation repression patients can survive after the disappearance of the differentiation repression. The detection kit provides positive meaningful reference data for further treatment schemes.
Owner:李海

Reducing myocardial reperfusion injury by the combination therapy of protein kinase a activation and b1-adrenergic receptor blockade

ActiveUS20110190206A1Reduce reperfusion injuryTreating and limiting reperfusion injuryBiocidePeptide/protein ingredientsProtein kinase A activationCardiac muscle
Embodiments of the invention are directed to methods of treating reperfusion or resuscitation injury in an individual in need of such treatment, comprising the step of administering to the individual who has had, having, or is at immediate risk of having an ischemic event an amount of a composition comprising a protein kinase A (PKA) activator and a β1-adrenergic receptor antagonist sufficient to reduce reperfusion injury to an ischemic tissue.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST

Bedside or intra operative assessment of tissue damage depth and readiness for reconstruction

A short wave infrared (SWIR) imaging system and method of using the same is provided for assessing a tissue damage depth and / or readiness for reconstruction and / or debridement. The SWIR imaging system includes a light source for illuminating the wound or burn, an image light-registering camera system having at least one narrow-band SWIR filter to image the wound or burn and output imaging information, and a detection system for receiving the imaging information and processing the imaging information to determine a tissue damage depth and / or readiness for reconstruction and / or debridement assessment.
Owner:RGT UNIV OF MICHIGAN

Methods and materials for assessing immune system profiles

This document provides methods and materials involved in assessing immune system profiles. For example, methods and materials for performing flow cytometry to determine the number of CD4+ lymphocytes, CD8+ lymphocytes, regulatory T cells, B cells, NK cells, granulocytes, CD14+HLA-DRlo / neg monocytes, and / or CD86+ monocytes per unit volume (e.g., cells per μL or mL) of whole blood (e.g., fresh, un-manipulated whole blood) obtained from a mammal (e.g., a human) are provided.
Owner:MAYO FOUND FOR MEDICAL EDUCATION & RES
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