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Fulvestrant, a steroidal antiestrogen and a drug used in the treatment of breast cancer. Antiestrogens, also known as estrogen antagonists or estrogen blockers, are a class of drugs which prevent estrogens like estradiol from mediating their biological effects in the body.
A compound, a preparation method thereof, a pharmaceutical composition and application thereof
This application discloses a compound, its preparation method, pharmaceutical composition, and application, belonging to the field of pharmaceutical synthesis and application technology. The compound is selected from formula (I) or formula (II). This compound can improve oral bioavailability, enabling oral administration and solving a series of problems associated with injecting fulvestrant in clinical practice. In vivo, it can be metabolized to produce fulvestrant and can inhibit / degrade estrogen receptor prodrug molecules, treating estrogen receptor-related diseases.
Owner:SHANDONG QIDU PHARMA