A system, method, software arrangement and computer-accessible medium for performing electronic cleansing of CT colonography images are provided. In this system, method, software arrangement and computer-accessible medium, the digital bowel cleansing can be performed to remove tagged bowel contents from the images. The digital bowel cleansing can apply a local shape analysis throughout the images and use a shape-based speed function to detect the folds and polyps structures while removing the tagged bowel contents region. The system, method, software arrangement and computer-accessible medium can enable a medical examiner to perform an accurate virtual colonoscopy on a patient, without the need for thorough patient preparation.